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Dissecting specific and global transcriptional regulation of bacterial gene expression
Molecular Systems Biology, 2013 Gene expression is regulated by specific transcriptional circuits but also by the global expression machinery as a function of growth. Simultaneous specific and global regulation thus constitutes an additional—but often neglected—layer of complexity in ...
Luca Gerosa +3 more
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Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Toxin-antitoxin (TA) systems are small genetic elements ubiquitous in prokaryotic genomes that encode toxic proteins targeting various vital cellular functions.
Ralph eBertram, Christopher F Schuster
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Microbiology Spectrum, 2021 Noncoding small RNAs (sRNAs) are crucial for the posttranscriptional regulation of gene expression in all organisms and are known to be involved in the regulation of bacterial virulence.
Kyung Moon +12 more
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Computational and Structural Biotechnology Journal, 2022 The BvgAS two-component system regulates virulence gene expression in Bordetella pertussis. Although precise three-dimensional structural information is not available for the response regulator BvgA, its sequence conservation with E.
David Kim +12 more
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Status quo of tet regulation in bacteria
Microbial Biotechnology, 2022 Summary The tetracycline repressor (TetR) belongs to the most popular, versatile and efficient transcriptional regulators used in bacterial genetics. In the tetracycline (Tc) resistance determinant tet(B) of transposon Tn10, tetR regulates the expression
Ralph Bertram +2 more
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Algorithm for the Reconstruction of Mathematical Frame Models of Bacterial Transcription Regulation
Mathematics, 2022 Transcription regulation plays an important role in bacterial activity. The operon concept coined by François Jacob and Jacques Monod has had a considerable effect on investigations into gene expression regulation, including modeling.
Tatiana N. Lakhova +5 more
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Journal of Microbiology & Biology Education, 2021 Practical lab exercises that help students draw connections between genotype and phenotype, and make and test predictions about the identity of mutants, are invaluable in college-level cell biology, genetics, and microbiology courses. While many bacteria
Anna L. McLoon +2 more
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Mode of Regulation and the Insulation of Bacterial Gene Expression [PDF]
Molecular Cell, 2012 A gene can be said to be insulated from environmental variations if its expression level depends only on its cognate inducers, and not on variations in conditions. We tested the insulation of the lac promoter of E. coli and of synthetic constructs in which the transcription factor CRP acts as either an activator or a repressor, by measuring their input
Vered Sasson +4 more
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Epigenetic silencing of host cell defense genes enhances intracellular survival of the rickettsial pathogen Anaplasma phagocytophilum. [PDF]
PLoS Pathogens, 2009 Intracellular bacteria have evolved mechanisms that promote survival within hostile host environments, often resulting in functional dysregulation and disease.
Jose C Garcia-Garcia +3 more
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Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes
Scientific Reports, 2022 AbstractLithium is rare in Earth’s crust compared to the biologically relevant alkali metal cations sodium and potassium but can accumulate to toxic levels in some environments. We report the experimental validation of two distinct bacterial riboswitch classes that selectively activate gene expression in response to elevated Li+ concentrations.
Neil White +4 more
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