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Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems

open access: yesFrontiers in Cellular and Infection Microbiology, 2014
Toxin-antitoxin (TA) systems are small genetic elements ubiquitous in prokaryotic genomes that encode toxic proteins targeting various vital cellular functions.
Ralph eBertram, Christopher F Schuster
doaj   +2 more sources

Post-transcriptional regulation of gene expression in Yersinia species

open access: yesFrontiers in Cellular and Infection Microbiology, 2012
Proper regulation of gene expression is required by bacterial pathogens to respond to continually changing environmental conditions and the host response during the infectious process.
Chelsea A Schiano, Wyndham W Lathem
doaj   +2 more sources

Diversity and Versatility in Small RNA-Mediated Regulation in Bacterial Pathogens

open access: yesFrontiers in Microbiology, 2021
Bacterial gene expression is under the control of a large set of molecules acting at multiple levels. In addition to the transcription factors (TFs) already known to be involved in global regulation of gene expression, small regulatory RNAs (sRNAs) are ...
Brice Felden, Yoann Augagneur
doaj   +2 more sources

Virulence Regulation in Borrelia burgdorferi [PDF]

open access: yesMicroorganisms
Borrelia burgdorferi, the causative agent of Lyme disease, is the most common vector-borne disease in the United States. Compared with other bacterial pathogens, B. burgdorferi has many unique features.
Sierra George, Zhiming Ouyang
doaj   +2 more sources

Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response [PDF]

open access: yes, 2013
Devon Kavanaugh is in receipt of a Teagasc Walsh Fellowship. The authors would also like to acknowledge the support of Science Foundation Ireland under Grant No.
Butto, Ludovica F.   +8 more
core   +20 more sources

Identification of BvgA-Dependent and BvgA-Independent Small RNAs (sRNAs) in Bordetella pertussis Using the Prokaryotic sRNA Prediction Toolkit ANNOgesic

open access: yesMicrobiology Spectrum, 2021
Noncoding small RNAs (sRNAs) are crucial for the posttranscriptional regulation of gene expression in all organisms and are known to be involved in the regulation of bacterial virulence.
Kyung Moon   +12 more
doaj   +1 more source

Conformational change of the Bordetella response regulator BvgA accompanies its activation of the B. pertussis virulence gene fhaB

open access: yesComputational and Structural Biotechnology Journal, 2022
The BvgAS two-component system regulates virulence gene expression in Bordetella pertussis. Although precise three-dimensional structural information is not available for the response regulator BvgA, its sequence conservation with E.
David Kim   +12 more
doaj   +1 more source

Status quo of tet regulation in bacteria

open access: yesMicrobial Biotechnology, 2022
Summary The tetracycline repressor (TetR) belongs to the most popular, versatile and efficient transcriptional regulators used in bacterial genetics. In the tetracycline (Tc) resistance determinant tet(B) of transposon Tn10, tetR regulates the expression
Ralph Bertram   +2 more
doaj   +1 more source

Optimized gene expression from bacterial chromosome by high-throughput integration and screening

open access: yesScience Advances, 2020
Pathway gene expression from the chromosome is optimized by a method of random site integrations and high-throughput screening. Chromosomal integration of recombinant genes is desirable compared with expression from plasmids due to increased stability ...
T. Saleski   +5 more
semanticscholar   +1 more source

Algorithm for the Reconstruction of Mathematical Frame Models of Bacterial Transcription Regulation

open access: yesMathematics, 2022
Transcription regulation plays an important role in bacterial activity. The operon concept coined by François Jacob and Jacques Monod has had a considerable effect on investigations into gene expression regulation, including modeling.
Tatiana N. Lakhova   +5 more
doaj   +1 more source

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