Results 31 to 40 of about 651,815 (307)

In vivo analysis of staphylococcus aureus-infected mice reveals differential temporal and spatial expression patterns of fhuD2 [PDF]

, 2017
Staphylococcus aureus is an opportunistic human pathogen and a major cause of invasive infections such as bacteremia, endocarditis, pneumonia and wound infections.
Bacconi, Marta, Bagnoli, Fabio, Bensi, Giuliano, Chiarot, Emiliano, Delany, Isabel, Donato, Paolo, Freitag, Nancy E., Haag, Andreas F.   +7 more
core   +1 more source

Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment. [PDF]

, 2017
Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional ...
Aaron T. Whiteley, Bret N. Peterson, Daniel A. Portnoy, Jeff F. Miller, Jonathan L. Portman, Samuel B. Dubensky   +5 more
core   +6 more sources

Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems

Frontiers in Cellular and Infection Microbiology, 2014
Toxin-antitoxin (TA) systems are small genetic elements ubiquitous in prokaryotic genomes that encode toxic proteins targeting various vital cellular functions.
Ralph eBertram, Christopher F Schuster
doaj   +1 more source

Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells [PDF]

ACS Synthetic Biology, 2018
Functional genomics studies in minimal mycoplasma cells enable unobstructed access to some of the most fundamental processes in biology. Conventional transposon bombardment and gene knockout approaches often fail to reveal functions of genes that are essential for viability, where lethality precludes phenotypic characterization.
Ana M. Mariscal, Shigeyuki Kakizawa, Jonathan Y. Hsu, Kazuki Tanaka, Luis González-González, Alicia Broto, Enrique Querol, Maria Lluch-Senar, Carlos Piñero-Lambea, Lijie Sun, Philip D. Weyman, Kim S. Wise, Chuck Merryman, Gavin Tse, Adam J. Moore, Clyde A. Hutchison, Hamilton O. Smith, Masaru Tomita, J. Craig Venter, John I. Glass, Jaume Piñol, Yo Suzuki   +21 more
openaire   +5 more sources

A highly conserved sRNA downregulates multiple genes, including a σ54 transcriptional activator, in the virulence mode of Bordetella pertussis

mBio
Bacterial small non-coding RNA (sRNAs), together with the RNA chaperone Hfq, post-transcriptionally regulate gene expression by affecting ribosome binding or mRNA stability.
Minji Sim, Jeffers Nguyen, Karolína Škopová, Kyungyoon Yoo, Chin-Hsien Tai, Leslie Knipling, Qing Chen, David Kim, Summer Nolan, Rawan Elaksher, Nadim Majdalani, Hernan Lorenzi, Scott Stibitz, Kyung Moon, Deborah M. Hinton   +14 more
doaj   +1 more source

Roles of DNA Adenine Methylation in Regulating Bacterial Gene Expression and Virulence [PDF]

Infection and Immunity, 2001
DNA methylation provides a mechanism by which additional information is imparted to DNA, and such epigenetic information can alter the timing and targeting of cellular events ([47][1]). DNA methylation occurs throughout the living world, including bacteria, plants, and mammals. Until recently,
D A, Low, N J, Weyand, M J, Mahan
openaire   +2 more sources

Orthologous transcription factors in bacteria have different functions and regulate different genes. [PDF]

PLoS Computational Biology, 2007
Transcription factors (TFs) form large paralogous gene families and have complex evolutionary histories. Here, we ask whether putative orthologs of TFs, from bidirectional best BLAST hits (BBHs), are evolutionary orthologs with conserved functions.
Morgan N Price, Paramvir S Dehal, Adam P Arkin   +2 more
doaj   +1 more source

Regulation of asymmetries in the kinetics and protein numbers of bacterial gene expression

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
Genetic circuits change the status quo of cellular processes when their protein numbers cross thresholds. We investigate the regulation of RNA and protein threshold crossing propensities in Escherichia coli. From in vivo single RNA time-lapse microscopy data from multiple promoters, mutants, induction schemes and media, we study the asymmetry and ...
Sofia Startceva, Vinodh K. Kandavalli, Ari Visa, Andre S. Ribeiro   +3 more
openaire   +4 more sources

Regulation of bacterial virulence gene expression by cell envelope stress responses [PDF]

Virulence, 2014
The bacterial cytoplasm lies within a multilayered envelope that must be protected from internal and external hazards. This protection is provided by cell envelope stress responses (ESRs), which detect threats and reprogram gene expression to ensure survival.
Josué, Flores-Kim, Andrew J, Darwin
openaire   +2 more sources

Do small RNAs unlock the below ground microbiome-plant interaction mystery?

Frontiers in Molecular Biosciences, 2022
Over the past few decades, regulatory RNAs, such as small RNAs (sRNAs), have received increasing attention in the context of host-microbe interactions due to their diverse roles in controlling various biological processes in eukaryotes.
Roshan Regmi, Roshan Regmi, C. Ryan Penton, C. Ryan Penton, C. Ryan Penton, Jonathan Anderson, Jonathan Anderson, Vadakattu V. S. R. Gupta, Vadakattu V. S. R. Gupta   +8 more
doaj   +1 more source