Roles of DNA Adenine Methylation in Regulating Bacterial Gene Expression and Virulence [PDF]
DNA methylation provides a mechanism by which additional information is imparted to DNA, and such epigenetic information can alter the timing and targeting of cellular events ([47][1]). DNA methylation occurs throughout the living world, including bacteria, plants, and mammals. Until recently,
David A. Low+2 more
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Phenotypic Variation and Bistable Switching in Bacteria [PDF]
Microbial research generally focuses on clonal populations. However, bacterial cells with identical genotypes frequently display different phenotypes under identical conditions.
A Becskei+159 more
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Orthologous transcription factors in bacteria have different functions and regulate different genes. [PDF]
Transcription factors (TFs) form large paralogous gene families and have complex evolutionary histories. Here, we ask whether putative orthologs of TFs, from bidirectional best BLAST hits (BBHs), are evolutionary orthologs with conserved functions.
Morgan N Price+2 more
doaj +1 more source
Regulation of bacterial virulence gene expression by cell envelope stress responses [PDF]
The bacterial cytoplasm lies within a multilayered envelope that must be protected from internal and external hazards. This protection is provided by cell envelope stress responses (ESRs), which detect threats and reprogram gene expression to ensure survival.
Andrew J. Darwin, Josué Flores-Kim
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Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation [PDF]
Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little ...
Bengoechea, J+14 more
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Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]
Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika+3 more
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Sinorhizobium fredii HH103 RirA is required for oxidative stress resistance and efficient symbiosis with Soybean [PDF]
Members of Rhizobiaceae contain a homologue of the iron-responsive regulatory protein RirA. In different bacteria, RirA acts as a repressor of iron uptake systems under iron-replete conditions and contributes to ameliorate cell damage during oxidative ...
Acosta Jurado, Sebastián+7 more
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Use of Bacterial Quorum-Sensing Components to Regulate Gene Expression in Plants [PDF]
Abstract We describe an efficient inducible system to regulate gene expression in plants based on quorum-sensing components found in Gram-negative bacteria such as Agrobacterium tumefaciens. These bacteria monitor their own population density by utilizing members of the N-acyl homoserine lactone family as inducers and a transcriptional ...
Tuan-Hua David Ho+6 more
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A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita [PDF]
© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops.
A Clark+118 more
core +1 more source
Regulation of asymmetries in the kinetics and protein numbers of bacterial gene expression
Genetic circuits change the status quo of cellular processes when their protein numbers cross thresholds. We investigate the regulation of RNA and protein threshold crossing propensities in Escherichia coli. From in vivo single RNA time-lapse microscopy data from multiple promoters, mutants, induction schemes and media, we study the asymmetry and ...
Sofia Startceva+3 more
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