Results 31 to 40 of about 779,265 (203)
Multi-target regulation by small RNAs synchronizes gene expression thresholds and may enhance ultrasensitive behavior. [PDF]
PLoS ONE, 2012 Cells respond to external cues by precisely coordinating multiple molecular events. Co-regulation may be established by the so-called single-input module (SIM), where a common regulator controls multiple targets.
Jörn Matthias Schmiedel +2 more
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Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells [PDF]
ACS Synthetic Biology, 2018 Functional genomics studies in minimal mycoplasma cells enable unobstructed access to some of the most fundamental processes in biology. Conventional transposon bombardment and gene knockout approaches often fail to reveal functions of genes that are essential for viability, where lethality precludes phenotypic characterization.
Ana M. Mariscal +21 more
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Msphere, 2017 Even initially sensitive bacteria can rapidly thwart antibiotic treatment through stress response processes known as adaptive resistance. Adaptive resistance fosters transient tolerance increases and the emergence of mutations conferring heritable drug ...
Keesha E. Erickson +2 more
semanticscholar +1 more source
Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system
Current Genetics, 2018 Autoregulation is the direct modulation of gene expression by the product of the corresponding gene. Autoregulation of bacterial gene expression has been mostly studied at the transcriptional level, when a protein acts as the cognate transcriptional ...
Nela Nikolic
semanticscholar +1 more source
mBioBacterial small non-coding RNA (sRNAs), together with the RNA chaperone Hfq, post-transcriptionally regulate gene expression by affecting ribosome binding or mRNA stability.
Minji Sim +14 more
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FEMS Microbiology Reviews, 2019 Gene expression occurs in two essential steps: transcription and translation. In bacteria, the two processes are tightly coupled in time and space, and highly regulated. Tight regulation of gene expression is crucial.
Indra Bervoets, D. Charlier
semanticscholar +1 more source
Orthologous transcription factors in bacteria have different functions and regulate different genes. [PDF]
PLoS Computational Biology, 2007 Transcription factors (TFs) form large paralogous gene families and have complex evolutionary histories. Here, we ask whether putative orthologs of TFs, from bidirectional best BLAST hits (BBHs), are evolutionary orthologs with conserved functions.
Morgan N Price +2 more
doaj +1 more source
Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
Frontiers in Cellular and Infection Microbiology, 2019 Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial cells. These transcription regulators are responsible for many important cellular processes and also are involved in pathogenesis of bacteria.
Pavla Stojkova, P. Spidlova, J. Stulík
semanticscholar +1 more source
Bacterial endotoxin lipopolysaccharides regulate gene expression in human colon cancer cells
BMC Research Notes, 2023 Abstract Objective Lipopolysaccharide (LPS) is a major cell wall component of gram-negative bacteria. Colon bacteria contribute to LPS which promotes colon cancer metastasis. The objective of this study was to survey the effect of LPS on cell viability and gene expression of 55 molecular targets in human colon cancer ...
openaire +3 more sources
Do small RNAs unlock the below ground microbiome-plant interaction mystery?
Frontiers in Molecular Biosciences, 2022 Over the past few decades, regulatory RNAs, such as small RNAs (sRNAs), have received increasing attention in the context of host-microbe interactions due to their diverse roles in controlling various biological processes in eukaryotes.
Roshan Regmi +8 more
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