Results 241 to 250 of about 741,473 (304)

Beyond Clavulanic Acid biosynthesis: Exploring the broad regulatory impact of BldD in Streptomyces clavuligerus ATCC 27064. [PDF]

PLoS One
Patiño LF, Caicedo-Montoya C, Ríos-Estepa R.   +2 more
europepmc   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

miR-184 modulates Ilp8 to control developmental timing during normal growth conditions and in response to developmental perturbations. [PDF]

Development
Fernandes J, Naseem M, Mangattu Parambil AM, Varghese J.   +3 more
europepmc   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Oocyte vitrification disrupts zygotic genome activation in embryos by impairing maternal spliceosome translation and Crxos splicing. [PDF]

PLoS Genet
Qin J, Ning A, Han J, Chen X, Cao B, Yao Y, He X, Pan B, Wei Y, Du K, Zou S, Ye J, Yu G, Liang Q, Qiao J, Yan J, Zhou G.   +16 more
europepmc   +1 more source

When sperm age, their RNA code hits a cliff. [PDF]

EMBO J
Osumi N.
europepmc   +1 more source

Plant BTB (Broad-Complex, Tramtrack, and Bric-à-Brac) Proteins: Structural Features, Biological Functions, and Roles in Stress Responses. [PDF]

Plants (Basel)
Zhang Y, Xie J, Dai K, Yu Y, Wu L.
europepmc   +1 more source

<i>ZmMed31-ZmSIG2A</i> Coordinates ROS Homeostasis and LRR-RLK Signaling to Regulate Root Development. [PDF]

Plants (Basel)
Jiang D, Guo S, Yuan X, Zhang S, Zhang Y, Ning Y, Qu F, Niu Q, Cao M.   +8 more
europepmc   +1 more source

The Role of Endogenous Hormones in Regulating Early Development of Stone Fruit. [PDF]

Plants (Basel)
Zhang S, Sun Y, Zhou X, Deng Z.
europepmc   +1 more source