Results 81 to 90 of about 544,702 (294)

The Transcription Factor PoCon7 Is Essential for Fungal Viability and Regulates Chitinase Gene Expression in Penicillium oxalicum

International Journal of Molecular Sciences
The dynamic remodeling of the fungal cell wall depends on a balance between chitin synthesis and degradation. Chitinases are critical for nutrient acquisition, cell wall remodeling, and defense; yet, the upstream regulatory mechanisms controlling chitinase gene expression remain poorly understood.
Kexuan Ma, Haiyi Yuan, Jian Zhao, Yuqi Qin   +3 more
openaire   +2 more sources

The Ustilago maydis Cys₂His₂‐type zinc finger transcription factor Mzr1 regulates fungal gene expression during the biotrophic growth stage [PDF]

Molecular Microbiology, 2008
SummaryThe smut fungus Ustilago maydis establishes a biotrophic relationship with its host plant maize to progress through sexual development. Here, we report the identification and characterization of the Cys2His2‐type zinc finger protein Mzr1 that functions as a transcriptional activator during host colonization. Expression of the U.
Zheng, Y., Kief, J., Auffarth, K., Farfsing, J., Mahlert, M., Nieto, F., Basse, C.   +6 more
openaire   +3 more sources

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

MicroRNA Regulation of Host Immune Responses following Fungal Exposure

Frontiers in Immunology, 2018
Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity ...
Tara L. Croston, Angela R. Lemons, D. Beezhold, B. Green   +3 more
semanticscholar   +1 more source

Crystal Facet‐Polysaccharide Matching in CFS‐P Nanocrystals Drives Fungal Uptake, Vacuole Destruction, and Selective Antifungal Activity

Advanced Science, EarlyView.
Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang, Xiaojin Deng, Xujuan Huang, Yuhang Pan, Yao Qin, Lu Zhang, Le Xu, Tianyi Qin, Deteng Zhang, Yi Ma, Yalong Wang   +10 more
wiley   +1 more source

Differential expression of the hexose‐regulated fungal genes AmPAL and AmMst1 within Amanita/Populus ectomycorrhizas [PDF]

New Phytologist, 2001
Summary  At least three fungal ‘networks’ are formed in ectomycorrhizal symbiosis: the Hartig net, the sheath and extramatrical hyphae. Since these structures have different functions regarding uptake, storage and partitioning of carbohydrates and nutrients, regulation and coordination of metabolic fluxes are of special interest for ectomycorrhizal ...
Uwe Nehls, Andrea Bock, Margret Ecke, Rüdiger Hampp   +3 more
openaire   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Translational Regulation Promotes Oxidative Stress Resistance in the Human Fungal Pathogen Cryptococcus neoformans

mBio, 2019
Fungal survival in a mammalian host requires the coordinated expression and downregulation of a large cohort of genes in response to cellular stresses. Initial infection with C.
Jay Leipheimer, Amanda L. M. Bloom, C. Campomizzi, Yana Salei, J. Panepinto   +4 more
semanticscholar   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

The consciousness of stress: Functional roles of ORFs and MicroRNAs in tomato defense against fungal pathogens

Plant Stress
Tomato plants constantly encounter fungal pathogens, which trigger intricate defense mechanisms at the molecular level. Among these, upstream open reading frames (uORFs) and main open reading frames (mORFs), together with microRNAs (miRNAs), play pivotal
Misbah Naz, Zhibing Rui, Haowen Ni, Muhammad Rahil Afzal, Zhuo Chen   +4 more
doaj   +1 more source