Results 21 to 30 of about 1,031,970 (204)

Epigenetic regulation and therapeutic targets in the tumor microenvironment

Molecular Biomedicine, 2023
The tumor microenvironment (TME) is crucial to neoplastic processes, fostering proliferation, angiogenesis and metastasis. Epigenetic regulations, primarily including DNA and RNA methylation, histone modification and non-coding RNA, have been generally ...
Zhuojun Xie, Zirui Zhou, Shuxian Yang, Shiwen Zhang, B. Shao   +4 more
semanticscholar   +1 more source

Transcriptomic effects of di-(2-ethylhexyl)-phthalate in Syrian hamster embryo cells: an important role of early cytoskeleton disturbances in carcinogenesis?

BMC Genomics, 2011
Background Di-(2-ethylhexyl)-phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC) formulations and a potentially non-genotoxic carcinogen.
Atienzar Franck, Poupin Pascal, Landkocz Yann, Vasseur Paule   +3 more
doaj   +1 more source

Circular RNA as An Epigenetic Regulator in Chronic Liver Diseases

Cells, 2021
Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably cleared up by extracellular vesicles.
Xianhui Zeng, Xianglei Yuan, Qiuyu Cai, Chengwei Tang, Jinhang Gao   +4 more
doaj   +1 more source

Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis. [PDF]

, 2014
Barretts esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc).
Baffa, R, Bornschein, J, Braconi, C, Croce, CM, D'Angelo, E, Dall'Olmo, L, Fassan, M, Galasso, M, Gasparini, P, Nuovo, GJ, Pizzi, M, Realdon, S, Rugge, M, Souza, RF, Valeri, N, Vicentini, C, Volinia, S, Zaninotto, G   +17 more
core   +4 more sources

Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

Nature Communications, 2023
Here the authors demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by nitric oxide (NO). They also isolate a unique modulator (DBIC) that inhibits S-nitrosylation of DNMT3B, which mitigates cell proliferation and tumorigenic ...
K. Okuda, Kengo Nakahara, A. Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, N. Takasugi, K. Onuma, M. Osaki, F. Okada, Taichi Ukegawa, Y. Takeuchi, N. Yasui, Atsuko Yamashita, H. Marusawa, Y. Matsushita, T. Katagiri, T. Shibata, K. Uchida, Sheng-Yong Niu, Nhi Lang, Tomohiro Nakamura, Kam Y. J. Zhang, S. Lipton, T. Uehara   +29 more
semanticscholar   +1 more source

Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer

International Journal of Cell Biology, 2013
Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary
Chiara Naro, Claudio Sette
doaj   +1 more source

hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer

Molecular Cancer, 2005
Background The genetic and molecular mechanisms responsible for and associated with the development and progression of prostate malignancy are largely unidentified.
Kajdacsy-Balla André, Singh Keshav K, Desouki Mohamed M, Milon B, Feng Pei, Franklin Renty B, Bagasra Omar, Costello Leslie C   +7 more
doaj   +1 more source

Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]

, 2017
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo, Kowalik, MARTA ANNA, Perra, Andrea   +2 more
core   +2 more sources

Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa [PDF]

, 2006
The causative molecular pathways underlying the pathogenesis of colorectal cancer (CRC) need to be better characterized. The purpose of our study was to better understand the genetic mechanism of oncogenesis for human colorectal cancer and to identify ...
Bianchini, Michele, Carinci, Paolo, De Sanctis, Paola, Levy, Estrella Mariel, Macagno, Carlo, Mordoh, Jose, Pinski, Victor, Valvassori, Luisa, Zucchini, Cinzia   +8 more
core   +1 more source

The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Analytical Cellular Pathology, 2010
Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of ...
Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos   +9 more
doaj   +1 more source