Results 151 to 160 of about 2,699,650 (306)

The genetic architecture of gene expression regulation in a <i>Citrus x Poncirus</i> hybrid tolerant to Huanglongbing. [PDF]

Front Plant Sci
Diaz IA, Zayed O, Ávila De Dios E, Jiang C, Bowman KD, Seymour DK.   +5 more
europepmc   +1 more source

Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability. [PDF]

PLoS Biol, 2023
Kelliher CM, Stevenson EL, Loros JJ, Dunlap JC.   +3 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Nuclear functional role of metabolic enzymes and related metabolites: Focus on gene expression regulation. [PDF]

Mol Metab
Todisco S, Iacobazzi D, Santarsiero A, Convertini P, Infantino V.   +4 more
europepmc   +1 more source

Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media. [PDF]

Front Cell Infect Microbiol, 2022
Janoušková M, Straw ML, Su YC, Riesbeck K.   +3 more
europepmc   +1 more source

Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis [PDF]

, 2019
John D. Welsh, Mark H. Hoofnagle, Sharika Bamezai, Michael Oxendine, Lillian Yuxian Lim, Joshua D. Hall, Jisheng Yang, Susan K. Schultz, James Douglas Engel, Tsutomu Kume, Guillermo Oliver, Juan M. Jiménez, Mark L. Kahn   +12 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Elucidating the role of mycobacteriophage D29-encoded Gp36 in DNA binding and phage gene expression regulation. [PDF]

Nucleic Acids Res
Pillai SS, Jain V.
europepmc   +1 more source

Dental and Orthopaedic Implant Loosening: Overlap in Gene Expression Regulation. [PDF]

Front Immunol, 2022
Schluessel S, Hartmann ES, Koehler MI, Beck F, Redeker JI, Saller MM, Akova E, Krebs S, Holzapfel BM, Mayer-Wagner S.   +9 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source