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Gene regulation by long non-coding RNAs and its biological functions
Nature Reviews Molecular Cell Biology, 2020 Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is ...
Luisa Statello +2 more
exaly +2 more sources
An enhanced CRISPR repressor for targeted mammalian gene regulation. [PDF]
Nature Methods, 2018 The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
Cecchi, Ryan J +20 more
core +2 more sources
Post-transcriptional gene regulation by mRNA modifications
Nature Reviews Molecular Cell Biology, 2016 Boxuan Simen Zhao, Chuan He
exaly +2 more sources
The molecular principles of gene regulation by Polycomb repressive complexes
Nature reviews. Molecular cell biology, 2021 Precise control of gene expression is fundamental to cell function and development. Although ultimately gene expression relies on DNA-binding transcription factors to guide the activity of the transcription machinery to genes, it has also become clear ...
Neil P. Blackledge, R. Klose
semanticscholar +1 more source
Cell & Bioscience, 2022 Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García +6 more
doaj +1 more source
CTCF and cohesin promote focal detachment of DNA from the nuclear lamina
Genome Biology, 2022 Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs.
Tom van Schaik +5 more
doaj +1 more source
Transcription factors: Bridge between cell signaling and gene regulation
Proteomics, 2021 Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as differentiation and development, and of the cellular response to external perturbation through signaling pathways.
Paula Weidemüller +3 more
semanticscholar +1 more source
The role of CPEB family proteins in the nervous system function in the norm and pathology
Cell & Bioscience, 2021 Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and ...
Eugene Kozlov +4 more
doaj +1 more source
Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria
bioRxiv, 2021 Bacteria allocate their proteome to cellular functions differently in different growth conditions. It is largely unknown how such allocation arises from known mechanisms of gene regulation while constrained by limited translation capacity and fixed ...
Rohan Balakrishnan +6 more
semanticscholar +1 more source
Scientific Reports, 2021 Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α regulate metabolic adaptation by modulating many gene programs. Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by ...
Jihyun Kim +6 more
doaj +1 more source