Results 1 to 10 of about 11,514,562 (351)
Gene Regulation and Speciation [PDF]
Trends in Genetics, 2017 Understanding the genetic architecture of speciation is a major goal in evolutionary biology. Hybrid dysfunction is thought to arise most commonly through negative interactions between alleles at two or more loci. Divergence between interacting regulatory elements that affect gene expression (i.e., regulatory divergence) may be a common route for these
Mack, Katya L, Nachman, Michael W
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The evolution of gene regulation
eLife, 2017 The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
Veronica Hinman, Gregory Cary
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Gene Regulation and Transcriptomics [PDF]
Current Issues in Molecular Biology, 2021 Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition from a vertebrate host to a tick vector and transmission from a tick vector to a vertebrate host.
Samuels, D. Scott +8 more
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The molecular principles of gene regulation by Polycomb repressive complexes
Nature reviews. Molecular cell biology, 2021 Precise control of gene expression is fundamental to cell function and development. Although ultimately gene expression relies on DNA-binding transcription factors to guide the activity of the transcription machinery to genes, it has also become clear ...
Neil P. Blackledge, R. Klose
semanticscholar +1 more source
Regulation of the Globin Genes [PDF]
Pediatric Research, 2002 The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed exclusively in the erythroid cells, only during defined periods of development and in a perfectly tuned way, assuring, at any stage of ontogeny, a correct balance in the availability of a- and b-globin chains for hemoglobin assembling. Such a tight control
Cao A, MOI, PAOLO
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Transcription factors: Bridge between cell signaling and gene regulation
Proteomics, 2021 Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as differentiation and development, and of the cellular response to external perturbation through signaling pathways.
Paula Weidemüller +3 more
semanticscholar +1 more source
Gene regulation by long non-coding RNAs and its biological functions
Nature reviews. Molecular cell biology, 2020 Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is ...
Luisa Statello +3 more
semanticscholar +1 more source
Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria
bioRxiv, 2021 Bacteria allocate their proteome to cellular functions differently in different growth conditions. It is largely unknown how such allocation arises from known mechanisms of gene regulation while constrained by limited translation capacity and fixed ...
Rohan Balakrishnan +6 more
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At the dawn: cell-free DNA fragmentomics and gene regulation
British Journal of Cancer, 2021 Epigenetic mechanisms play instrumental roles in gene regulation during embryonic development and disease progression. However, it is challenging to non-invasively monitor the dynamics of epigenomes and related gene regulation at inaccessible human ...
Yaping Liu
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Histone crotonylation-centric gene regulation
Epigenetics & Chromatin, 2021 Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements ...
Kun Li, Ziqiang Wang
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