Results 11 to 20 of about 11,514,562 (351)
An enhanced CRISPR repressor for targeted mammalian gene regulation [PDF]
Nature Methods, 2018 The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
N. C. Yeo +19 more
semanticscholar +3 more sources
Regulation of the erythropoietin gene [PDF]
Stem Cells, 1993 Erythropoietin (Epo), the hormone that stimulates red blood cell production, is induced by hypoxia. We have utilized the human hepatoma cell line, Hep3B, to investigate the regulation of the Epo gene. We present evidence that the oxygen sensor in Hep3B cells is a heme protein.
Kerry L. Blanchard +3 more
+8 more sources
Nanoplasmonic gene regulation [PDF]
Current Opinion in Chemical Biology, 2010 This review focuses on the recent developments in nanoplasmonic gene regulations. Types of nanoplasmonic carriers and DNA/RNA cargo are described. Strategies to liberate cargo from their carriers using NIR and enable on-demand silencing of endogenous intracellular genes are reviewed.
Somin Eunice Lee, Luke P. Lee
openaire +3 more sources
Argonaute—a database for gene regulation by mammalian microRNAs
BMC Bioinformatics, 2005 BackgroundThe Sulston score is a well-established, though approximate metric for probabilistically evaluating postulated clone overlaps in DNA fingerprint mapping.
Priyanka Shahi +9 more
semanticscholar +1 more source
Specificity of Gene Regulation [PDF]
Cell, 2002 The physiologically coordinated expression of our genome requires exquisite regulation of gene specificity. Recent advances demonstrate that this formidable task is accomplished by diverse mechanisms and networks that operate at distinct levels within the nucleus.
openaire +3 more sources
Nucleus and gene regulation [PDF]
Current Opinion in Cell Biology, 2006 At the close of a 1973 meeting on Chromosome Structure and Function, an observer commented that chromosomes resembled “a bad day at a macaroni factory” [1]. But things change. Only a few months later nucleosomes were discovered and within just a few more years it began to be appreciated that the nucleus is organized as functionally distinct domains ...
Thoru Pederson, Robert H. Singer
openaire +3 more sources
Bacterial nitrate assimilation: gene distribution and regulation [PDF]
, 2011 In the context of the global nitrogen cycle, the importance of inorganic nitrate for the nutrition and growth of marine and freshwater autotrophic phytoplankton has long been recognized.
Andrew J. Gates +44 more
core +1 more source
Tumor suppressor p53: from engaging DNA to target gene regulation
Nucleic Acids Research, 2020 The p53 transcription factor confers its potent tumor suppressor functions primarily through the regulation of a large network of target genes. The recent explosion of next generation sequencing protocols has enabled the study of the p53 gene regulatory ...
Morgan A. Sammons +3 more
semanticscholar +1 more source
Gene regulation and epigenotype in Friedreich's ataxia [PDF]
, 2008 Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core +2 more sources
Gene Regulation in and out of Equilibrium.
Annual Review of Biophysics, 2020 Determining whether and how a gene is transcribed are two of the central processes of life. The conceptual basis for understanding such gene regulation arose from pioneering biophysical studies in eubacteria.
Felix Wong, J. Gunawardena
semanticscholar +1 more source