Results 11 to 20 of about 1,691,605 (342)
Cells, 2021 Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome ...
Zaur M. Kachaev +4 more
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NF90 interacts with components of RISC and modulates association of Ago2 with mRNA
BMC Biology, 2022 Background Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms such as transcription, translation, viral infection, and mRNA stability.
Giuseppa Grasso +6 more
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Gene Therapy for Acquired and Genetic Cholestasis
Biomedicines, 2022 Cholestatic diseases can be caused by the dysfunction of transporters involved in hepatobiliary circulation. Although pharmacological treatments constitute the current standard of care for these diseases, none are curative, with liver transplantation ...
Javier Martínez-García +4 more
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Nanoplasmonic gene regulation [PDF]
Current Opinion in Chemical Biology, 2010 This review focuses on the recent developments in nanoplasmonic gene regulations. Types of nanoplasmonic carriers and DNA/RNA cargo are described. Strategies to liberate cargo from their carriers using NIR and enable on-demand silencing of endogenous intracellular genes are reviewed.
Somin Eunice Lee, Luke P. Lee
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Chromatin complex dependencies reveal targeting opportunities in leukemia
Nature Communications, 2023 Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with ...
Fadi J. Najm +11 more
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Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
Nature Communications, 2020 ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren +11 more
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AMB Express, 2019 Epsilon toxin (Etx) produced by Clostridium perfringens types B and D, a major causative agent of enterotoxaemia causes significant economic losses to animal industry.
Himani Kaushik +5 more
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Specificity of Gene Regulation [PDF]
Cell, 2002 The physiologically coordinated expression of our genome requires exquisite regulation of gene specificity. Recent advances demonstrate that this formidable task is accomplished by diverse mechanisms and networks that operate at distinct levels within the nucleus.
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Proximity labeling identifies a repertoire of site-specific R-loop modulators
Nature Communications, 2022 R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan +6 more
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MicroRNAs preferentially target the genes with high transcriptional regulation complexity [PDF]
Biochem Biophys Res Commun., 352:733-738, 2007, 2006 Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal genomes at post-transcriptional level. However, it is still unclear why some genes are regulated by miRNAs but others are not, i.e.
arxiv +1 more source