Results 11 to 20 of about 2,989,814 (357)
Gene regulation in transition [PDF]
Nature, 2016 An in-depth analysis of a close relative of animals, Capsaspora owczarzaki, provides clues to the changes in gene regulation that occurred during the transition to multicellularity.
Booth, David S, King, Nicole
openaire +6 more sources
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Nature Communications, 2020 Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao +11 more
doaj +1 more source
Chromatin complex dependencies reveal targeting opportunities in leukemia
Nature Communications, 2023 Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with ...
Fadi J. Najm +11 more
doaj +1 more source
Gene Therapy for Acquired and Genetic Cholestasis
Biomedicines, 2022 Cholestatic diseases can be caused by the dysfunction of transporters involved in hepatobiliary circulation. Although pharmacological treatments constitute the current standard of care for these diseases, none are curative, with liver transplantation ...
Javier Martínez-García +4 more
doaj +1 more source
NF90 interacts with components of RISC and modulates association of Ago2 with mRNA
BMC Biology, 2022 Background Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms such as transcription, translation, viral infection, and mRNA stability.
Giuseppa Grasso +6 more
doaj +1 more source
Nanoplasmonic gene regulation [PDF]
Current Opinion in Chemical Biology, 2010 This review focuses on the recent developments in nanoplasmonic gene regulations. Types of nanoplasmonic carriers and DNA/RNA cargo are described. Strategies to liberate cargo from their carriers using NIR and enable on-demand silencing of endogenous intracellular genes are reviewed.
Somin Eunice Lee, Luke P. Lee
openaire +3 more sources
Integrated signaling pathway and gene expression regulatory model to dissect dynamics of Escherichia coli challenged mammary epithelial cells [PDF]
, 2014 Cells transform external stimuli, through the activation of signaling pathways, which in turn activate gene regulatory networks, in gene expression. As more omics data are generated from experiments, eliciting the integrated relationship between the ...
den Breems, Nicoline Y. +2 more
core +3 more sources
AMB Express, 2019 Epsilon toxin (Etx) produced by Clostridium perfringens types B and D, a major causative agent of enterotoxaemia causes significant economic losses to animal industry.
Himani Kaushik +5 more
doaj +1 more source
Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
Nature Communications, 2020 ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren +11 more
doaj +1 more source
Specificity of Gene Regulation [PDF]
Cell, 2002 The physiologically coordinated expression of our genome requires exquisite regulation of gene specificity. Recent advances demonstrate that this formidable task is accomplished by diverse mechanisms and networks that operate at distinct levels within the nucleus.
openaire +3 more sources