Results 11 to 20 of about 3,161,105 (354)
Brassinosteroid-Regulated Gene Expression [PDF]
Plant Physiology, 2002 Abstract Major brassinosteroid (BR) effects such as BR-induced growth are mediated through genomic pathways because RNA synthesis inhibitors and protein synthesis inhibitors interfere with these processes. A limited number of BR-regulated genes have been identified hitherto. The majority of genes (such as BRU1, CycD3,Lin6, OPR3, and TRIP-
Altmann, Thomas +2 more
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Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
Nature Communications, 2020 ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren +11 more
doaj +1 more source
Chromatin complex dependencies reveal targeting opportunities in leukemia
Nature Communications, 2023 Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with ...
Fadi J. Najm +11 more
doaj +1 more source
Journal of General Virology, 1987 Introduction. The parvoviruses are among the smallest of the DNA animal viruses (Siegl et al., 1985). The genome is a linear single-stranded DNA of approximately 5 kb which is encapsidated in a naked icosahedral virion 20 to 26 nm in diameter. There are two or three capsid proteins which have overlapping amino acid sequences; the larger species have ...
K I, Berns, M A, Labow
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AMB Express, 2019 Epsilon toxin (Etx) produced by Clostridium perfringens types B and D, a major causative agent of enterotoxaemia causes significant economic losses to animal industry.
Himani Kaushik +5 more
doaj +1 more source
Wellcome Open Research, 2018 Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly +6 more
doaj +1 more source
Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]
, 2017 Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core +1 more source
Proximity labeling identifies a repertoire of site-specific R-loop modulators
Nature Communications, 2022 R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan +6 more
doaj +1 more source
Bacterial nitrate assimilation: gene distribution and regulation [PDF]
, 2011 In the context of the global nitrogen cycle, the importance of inorganic nitrate for the nutrition and growth of marine and freshwater autotrophic phytoplankton has long been recognized.
Andrew J. Gates +44 more
core +1 more source
Frontiers in Genetics, 2022 DNA double-strand breaks (DSBs) can be repaired through various pathways. Understanding how these pathways are regulated is of great interest for cancer research and optimization of gene editing.
Ruben Schep +5 more
doaj +1 more source