Mathematical approaches to differentiation and gene regulation [PDF]
We consider some mathematical issues raised by the modelling of gene networks. The expression of genes is governed by a complex set of regulations, which is often described symbolically by interaction graphs. Once such a graph has been established, there
Soulé, C.
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Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
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Introduction. The parvoviruses are among the smallest of the DNA animal viruses (Siegl et al., 1985). The genome is a linear single-stranded DNA of approximately 5 kb which is encapsidated in a naked icosahedral virion 20 to 26 nm in diameter. There are two or three capsid proteins which have overlapping amino acid sequences; the larger species have ...
M A Labow, Kenneth I. Berns
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Co-Regulated Genes and Gene Clusters [PDF]
There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with
Sergey V. Razin+3 more
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Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways. [PDF]
Anautogenous mosquito females require a meal of vertebrate blood in order to initiate the production of yolk protein precursors by the fat body. Yolk protein precursor gene expression is tightly repressed in a state-of-arrest before blood meal-related ...
Attardo, Geoffrey M+3 more
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From Linear Genes to Epigenetic Inheritance of Three-dimensional Epigenomes [PDF]
Fifty years ago Jacob and Monod reported their findings on the regulation of gene activity. Working on lambda bacteriophage lysogeny and the regulation of the production of an enzyme that cleaves lactose, they observed that its production was induced by ...
Cavalli, Giacomo
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The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans [PDF]
Despite the importance of microRNAs (miRNAs) in gene regulation, it is unclear how the miRNA-Argonaute complex-or miRNA-induced silencing complex (miRISC)-can regulate the translation of their targets in such diverse ways.
Bajan, Sarah+7 more
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Frequency-modulated nuclear localization bursts coordinate gene regulation [PDF]
In yeast, the transcription factor Crz1 is dephosphorylated and translocates into the nucleus in response to extracellular calcium. Here we show, using time-lapse microscopy, that Crz1 exhibits short bursts of nuclear localization (typically lasting 2 ...
Cai, Long+2 more
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Metabolic regulation of gene expression by histone lactylation
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells.
Di Zhang+23 more
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Stochastic modeling of regulation of gene expression by multiple small RNAs
A wealth of new research has highlighted the critical roles of small RNAs (sRNAs) in diverse processes such as quorum sensing and cellular responses to stress.
Baker, Charles+2 more
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