Results 21 to 30 of about 2,989,814 (357)
Nucleus and gene regulation [PDF]
At the close of a 1973 meeting on Chromosome Structure and Function, an observer commented that chromosomes resembled “a bad day at a macaroni factory” [1]. But things change. Only a few months later nucleosomes were discovered and within just a few more years it began to be appreciated that the nucleus is organized as functionally distinct domains ...
Thoru Pederson, Robert H. Singer
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Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly+6 more
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DNA double-strand breaks (DSBs) can be repaired through various pathways. Understanding how these pathways are regulated is of great interest for cancer research and optimization of gene editing.
Ruben Schep+5 more
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The evolution of gene regulation
The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
Veronica Hinman, Gregory Cary
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Towards molecular systems biology of gene transcription and regulation [PDF]
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, Patrick
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Proximity labeling identifies a repertoire of site-specific R-loop modulators
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan+6 more
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Mechanical determinants of chromatin topology and gene expression
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin.
Rajiv Kumar Jha+2 more
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Regulation of skeletal muscle development and homeostasis by gene imprinting, histone acetylation and microRNA [PDF]
Epigenetics is defined as heritable information other that the DNA sequence itself. The concept implies that the regulation of gene expression is highly complex and epigenetics can control from fine tuning to permanent gene activation/deactivation ...
ADAMO, Sergio+3 more
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PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription
Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. Compared to its well-characterized role in mitosis, little is known about PLK1 functions in interphase.
Michael Wierer+6 more
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Introduction. The parvoviruses are among the smallest of the DNA animal viruses (Siegl et al., 1985). The genome is a linear single-stranded DNA of approximately 5 kb which is encapsidated in a naked icosahedral virion 20 to 26 nm in diameter. There are two or three capsid proteins which have overlapping amino acid sequences; the larger species have ...
M A Labow, Kenneth I. Berns
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