Results 21 to 30 of about 2,989,814 (357)

Nucleus and gene regulation [PDF]

open access: yesCurrent Opinion in Cell Biology, 2006
At the close of a 1973 meeting on Chromosome Structure and Function, an observer commented that chromosomes resembled “a bad day at a macaroni factory” [1]. But things change. Only a few months later nucleosomes were discovered and within just a few more years it began to be appreciated that the nucleus is organized as functionally distinct domains ...
Thoru Pederson, Robert H. Singer
openaire   +3 more sources

Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells [version 1; referees: 2 approved, 1 approved with reservations]

open access: yesWellcome Open Research, 2018
Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly   +6 more
doaj   +1 more source

Protocol: A Multiplexed Reporter Assay to Study Effects of Chromatin Context on DNA Double-Strand Break Repair

open access: yesFrontiers in Genetics, 2022
DNA double-strand breaks (DSBs) can be repaired through various pathways. Understanding how these pathways are regulated is of great interest for cancer research and optimization of gene editing.
Ruben Schep   +5 more
doaj   +1 more source

The evolution of gene regulation

open access: yeseLife, 2017
The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
Veronica Hinman, Gregory Cary
openaire   +4 more sources

Towards molecular systems biology of gene transcription and regulation [PDF]

open access: yes, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, Patrick
core   +1 more source

Proximity labeling identifies a repertoire of site-specific R-loop modulators

open access: yesNature Communications, 2022
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan   +6 more
doaj   +1 more source

Mechanical determinants of chromatin topology and gene expression

open access: yesNucleus, 2022
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin.
Rajiv Kumar Jha   +2 more
doaj   +1 more source

Regulation of skeletal muscle development and homeostasis by gene imprinting, histone acetylation and microRNA [PDF]

open access: yes, 2015
Epigenetics is defined as heritable information other that the DNA sequence itself. The concept implies that the regulation of gene expression is highly complex and epigenetics can control from fine tuning to permanent gene activation/deactivation ...
ADAMO, Sergio   +3 more
core   +2 more sources

PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription

open access: yesCell Reports, 2013
Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. Compared to its well-characterized role in mitosis, little is known about PLK1 functions in interphase.
Michael Wierer   +6 more
doaj   +1 more source

Parvovirus Gene Regulation

open access: yesJournal of General Virology, 1987
Introduction. The parvoviruses are among the smallest of the DNA animal viruses (Siegl et al., 1985). The genome is a linear single-stranded DNA of approximately 5 kb which is encapsidated in a naked icosahedral virion 20 to 26 nm in diameter. There are two or three capsid proteins which have overlapping amino acid sequences; the larger species have ...
M A Labow, Kenneth I. Berns
openaire   +3 more sources

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