Results 41 to 50 of about 786,474 (343)

Evolving Robust Gene Regulatory Networks

PLOS ONE, 2015
Design and implementation of robust network modules is essential for construction of complex biological systems through hierarchical assembly of 'parts' and 'devices'. The robustness of gene regulatory networks (GRNs) is ascribed chiefly to the underlying topology.
Noman, Nasimul, Monjo, Taku, Moscato, Pablo, Iba, Hitoshi   +3 more
openaire   +4 more sources

GeRNet: a gene regulatory network tool [PDF]

Biosystems, 2017
Gene regulatory networks (GRNs) are crucial in every process of life since they govern the majority of the molecular processes. Therefore, the task of assembling these networks is highly important. In particular, the so called model-free approaches have an advantage modeling the complexities of dynamic molecular networks, since most of the gene ...
Dussaut, Julieta Sol, Gallo, Cristian Andrés, Cravero, Fiorella, Martínez, María Jimena, Carballido, Jessica Andrea, Ponzoni, Ignacio   +5 more
openaire   +3 more sources

Gene regulatory networks that control the specification of neural-crest cells in the lamprey [PDF]

, 2009
The lamprey is the only basal vertebrate in which large-scale gene perturbation analyses are feasible at present. Studies on this unique animal model promise to contribute both to the understanding of the basic neural-crest gene regulatory network ...
Bronner-Fraser, Marianne, Nikitina, Natalya V.   +1 more
core   +1 more source

Fan-out in gene regulatory networks [PDF]

Journal of Biological Engineering, 2010
In synthetic biology, gene regulatory circuits are often constructed by combining smaller circuit components. Connections between components are achieved by transcription factors acting on promoters. If the individual components behave as true modules and certain module interface conditions are satisfied, the function of the composite circuits can in ...
Sauro Herbert M, Kim Kyung H
openaire   +4 more sources

Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli [PDF]

, 2010
The set of regulatory interactions between genes, mediated by transcription factors, forms a species' transcriptional regulatory network (TRN). By comparing this network with measured gene expression data one can identify functional properties of the TRN
A Travers, C Marr, Carsten Marr, DP Sangurdekar, E Krause, Fabian J. Theis, G Balázsi, H Yu, J Vogel, J Ward Jr, JD Glasner, JJ Faith, Larry S. Liebovitch, M. Madan Babu, Marc-Thorsten Hütt, MJ Herrgard, N Blot, N Sonnenschein, NM Luscombe, O Alter, Q Cui, R Milo, R Milo, RM Gutierrez-Rios, S Gama-Castro, S Gottesman, S Mangan, S Mangan, S Mangan, SS Shen-Orr, T Beissbarth, VG Tusher   +31 more
core   +5 more sources

Metabolic constraint-based refinement of transcriptional regulatory networks. [PDF]

PLoS Computational Biology, 2013
There is a strong need for computational frameworks that integrate different biological processes and data-types to unravel cellular regulation. Current efforts to reconstruct transcriptional regulatory networks (TRNs) focus primarily on proximal data ...
Sriram Chandrasekaran, Nathan D Price
doaj   +1 more source

Assessing regulatory information in developmental gene regulatory networks [PDF]

Proceedings of the National Academy of Sciences, 2017
Gene regulatory networks (GRNs) provide a transformation function between the static genomic sequence and the primary spatial specification processes operating development. The regulatory information encompassed in developmental GRNs thus goes far beyond the control of individual genes.
Peter, Isabelle S., Davidson, Eric H.
openaire   +3 more sources

A novel mutual information-based Boolean network inference method from time-series gene expression data.

PLoS ONE, 2017
BackgroundInferring a gene regulatory network from time-series gene expression data in systems biology is a challenging problem. Many methods have been suggested, most of which have a scalability limitation due to the combinatorial cost of searching a ...
Shohag Barman, Yung-Keun Kwon
doaj   +1 more source

Inherent size constraints on prokaryote gene networks due to "accelerating" growth

, 2004
Networks exhibiting "accelerating" growth have total link numbers growing faster than linearly with network size and can exhibit transitions from stationary to nonstationary statistics and from random to scale-free to regular statistics at particular ...
Gagen, M. J., Mattick, J. S.
core   +1 more source

Research on Controllability of Gene Regulatory Network Based on Longest Control Chain [PDF]

Jisuanji gongcheng, 2018
In order to analyze the controllability of gene regulation network,in this paper,the gene regulatory network in human cell cycle is studied,and the structural control process of gene network is reconstructed based on the Boolean logic functions,which are
BAI Xueyi,GUO Binghui,LI Jiahui,ZHENG Zhiming
doaj   +1 more source