Results 61 to 70 of about 786,474 (343)

Mean field analysis of a spatial stochastic model of a gene regulatory network [PDF]

, 2014
A gene regulatory network may be defined as a collection of DNA segments which interact with each other indirectly through their RNA and protein products.
Chaplain, M. A. J., Matzavinos, A., Murray, P. J., Sturrock, M.   +3 more
core   +2 more sources

Effects of Time Point Measurement on the Reconstruction of Gene Regulatory Networks

Molecules, 2010
With the availability of high-throughput gene expression data in the post-genomic era, reconstruction of gene regulatory networks has become a hot topic.
Bairong Shen, Yuanyuan Zhang, Jiajia Chen, Yang Yang, Huangqiong Zhu, Wenying Yan   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A gene regulatory network armature for T lymphocyte specification [PDF]

, 2008
Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process,
Bolouri, Hamid, David-Fung, Elizabeth-Sharon, Georgescu, Constantin, Longabaugh, William J. R., Rothenberg, Ellen V., Scripture-Adams, Dierdre D., Yui, Mary A., Zarnegar, Mark A.   +7 more
core   +2 more sources

A systems biology approach to construct the gene regulatory network of systemic inflammation via microarray and databases mining

BMC Medical Genomics, 2008
Background Inflammation is a hallmark of many human diseases. Elucidating the mechanisms underlying systemic inflammation has long been an important topic in basic and clinical research. When primary pathogenetic events remains unclear due to its immense
Lan Chung-Yu, Yang Shih-Kuang, Chen Bor-Sen, Chuang Yung-Jen   +3 more
doaj   +1 more source

A novel approach GRNTSTE to reconstruct gene regulatory interactions applied to a case study for rat pineal rhythm gene

Scientific Reports, 2022
Accurate inference and prediction of gene regulatory network are very important for understanding dynamic cellular processes. The large-scale time series genomics data are helpful to reveal the molecular dynamics and dynamic biological processes of ...
Zhenyu Liu, Jing Gao, Tao Li, Yi Jing, Cheng Xu, Zhengtong Zhu, Dongshi Zuo, Junjie Chen   +7 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Gene Regulatory Network v1 [PDF]

, 2020
Gene regulatory networks (GRNs) provide a platform for integrating multiomic data and can be used to characterize the dynamics of perturbations during biological transitions such as puberty and other complex traits. We used a multiomics approach, which has the power to identify the control mechanisms underpinning complex traits (Argelaguet et al 2019 ...
Amin R Mohamed, Antonio Reverter, James Kijas   +2 more
openaire   +1 more source

Netter: re-ranking gene network inference predictions using structural network properties [PDF]

, 2016
Background: Many algorithms have been developed to infer the topology of gene regulatory networks from gene expression data. These methods typically produce a ranking of links between genes with associated confidence scores, after which a certain ...
Demeester, Piet, Dhaene, Tom, Ruyssinck, Joeri, Saeys, Yvan   +3 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source