Virus‐induced gene silencing database for phenomics and functional genomics in Nicotiana benthamiana [PDF]
Plant Direct, 2018 Virus‐induced gene silencing (VIGS) is an important forward and reverse genetics method for the study of gene function in many plant species, especially Nicotiana benthamiana.
Muthappa Senthil‐Kumar +15 more
doaj +3 more sources
Induction of RNAi Core Machinery’s Gene Expression by Exogenous dsRNA and the Effects of Pre-exposure to dsRNA on the Gene Silencing Efficiency in the Pea Aphid (Acyrthosiphon pisum) [PDF]
Frontiers in Physiology, 2019 The pea aphid, Acyrthosiphon pisum, is an important agricultural pest and biological model organism, and RNA interference (RNAi) is an important tool for functional genomics and for insect pest management. However, the efficiency of RNAi in pea aphids is
Chao Ye +18 more
doaj +4 more sources
Tertiary siRNAs mediate paramutation in C. elegans. [PDF]
PLoS Genetics, 2015 In the nematode Caenorhabditis elegans, different small RNA-dependent gene silencing mechanisms act in the germline to initiate transgenerational gene silencing. Piwi-interacting RNAs (piRNAs) can initiate transposon and gene silencing by acting upstream
Alexandra Sapetschnig +3 more
doaj +4 more sources
A protein assembly mediates Xist localization and gene silencing
Nature, 2020 Nuclear compartments have diverse roles in regulating gene expression, yet the molecular forces and components that drive compartment formation remain largely unclear1.
Amy Pandya-Jones +17 more
semanticscholar +1 more source
Conditional U1 gene silencing in Toxoplasma gondii [PDF]
, 2015 The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing.
Blackman, Michael J. +10 more
core +13 more sources
Gene Activation and Gene Silencing [PDF]
Plant Physiology, 2001 Twenty-five years ago the field of eukaryotic gene regulation was in its infancy. Paradigms driving experiments came primarily from work with prokaryotes and the phage that infected them (12). These paradigms, pioneered by Jacob and Monod, were that genes contained promoter sequences to which ...
Hervé Vaucheret, Vicki L. Chandler
openaire +3 more sources
eLife, 2022 In mammalian cells genes that are in close proximity can be transcriptionally coupled: silencing or activating one gene can affect its neighbors. Understanding these dynamics is important for natural processes, such as heterochromatin spreading during ...
Sarah Lensch +7 more
doaj +1 more source
Pygmy MicroRNA: Surveillance Cops in Therapy Kingdom
Molecular Medicine, 2016 MicroRNAs (miRNAs) are well preserved in every animal. These pygmy-sized (21–23 nt) noncoding RNAs scattered in the genome are responsible for micromanaging versatile gene regulation.
Utpal Bhadra +3 more
doaj +1 more source
MGMT gene silencing and benefit from temozolomide in glioblastoma.
New England Journal of Medicine, 2005 BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents.
M. Hegi +16 more
semanticscholar +1 more source
RNA-Mediated Gene Silencing Signals Are Not Graft Transmissible from the Rootstock to the Scion in Greenhouse-Grown Apple Plants Malus sp. [PDF]
, 2012 RNA silencing describes the sequence specific degradation of RNA targets. Silencing is a non-cell autonomous event that is graft transmissible in different plant species.
Bai +37 more
core +3 more sources