Results 11 to 20 of about 6,519,783 (149)
Targeted gene silencing in vivo by platelet membrane–coated metal-organic framework nanoparticles
Science Advances, 2020 Platelet-mimicking nanoparticles enable the targeted delivery of small interfering RNA to tumors for anticancer therapy. Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications ...
Zhuang Jia +6 more
semanticscholar +1 more source
A protein assembly mediates Xist localization and gene silencing
Nature, 2020 Nuclear compartments have diverse roles in regulating gene expression, yet the molecular forces and components that drive compartment formation remain largely unclear1.
Amy Pandya-Jones +17 more
semanticscholar +1 more source
MGMT gene silencing and benefit from temozolomide in glioblastoma.
New England Journal of Medicine, 2005 BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents.
M. Hegi +16 more
semanticscholar +1 more source
DNA nanostructures coordinate gene silencing in mature plants
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Plant bioengineering will be necessary to sustain plant biology and agriculture, where the delivery of biomolecules such as DNA, RNA, or proteins to plant cells is at the crux of plant biotechnology. Here, we show that DNA nanostructures can
Huan Zhang +8 more
semanticscholar +1 more source
siRNA Versus miRNA as Therapeutics for Gene Silencing
Molecular Therapy: Nucleic Acids, 2015 Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation.
J. Lam +3 more
semanticscholar +1 more source
Epigenetic silencing in transgenic plants
Frontiers in Plant Science, 2015 Epigenetic silencing is a natural phenomenon in which the expression of gene is regulated through modifications of DNA, RNA or histone proteins. It is a mechanism for defending host genomes against the effects of transposable element, viral infection and
Sarma eRajeev Kumar +2 more
doaj +1 more source
The Whys and Wherefores of Transitivity in Plants
Frontiers in Plant Science, 2020 Transitivity in plants is a mechanism that produces secondary small interfering RNAs (siRNAs) from a transcript targeted by primary small RNAs (sRNAs). It expands the silencing signal to additional sequences of the transcript.
Felipe F. de Felippes +1 more
doaj +1 more source
Molecular Plant-Microbe Interactions, 2003 Promoters isolated from the Tomato leaf curl virus (TLCV) drive both constitutive and tissue-specific expression in transgenic tobacco. Following systemic TLCV infection of plants stably expressing TLCV promoter:GUS transgenes, transgene expression ...
Mark Seemanpillai +3 more
doaj +1 more source
Application of RNA Interference to Root-Knot Nematode Genes Encoding Esophageal Gland Proteins
Molecular Plant-Microbe Interactions, 2005 Plant parasitic nematodes have been, so far, refractory to transformation or mutagenesis. The functional analysis of nematode genes relies on the development of reverse genetic tools adapted to these obligate parasites.
M.-N. Rosso +4 more
doaj +1 more source
The post-transcriptional gene silencing pathway in Eucalyptus
Genetics and Molecular Biology, 2005 Post-transcriptional gene silencing (PTGS) is a conserved surveillance mechanism that identifies and cleaves double-stranded RNA molecules and their cellular cognate transcripts.
Flávio Tetsuo Sassaki +2 more
doaj +1 more source