Results 231 to 240 of about 355,065 (295)

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

Advanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang, Linyu Han, Yanfei Huo, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang   +6 more
wiley   +1 more source

Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing

Nesic K, Geissler F, Xu L, Kyran E, Beard S, Vandenberg CJ, Liddell B, Olechnowicz SW, Topp M, McNally O, Ratnayake G, Traficante N, Australian Ovarian Cancer Study, DeFazio A, Bowtell DD, Pappenfuss T, Zhang F, Dobrovic A, Waddell N, Scott CL, Kondrashova O, Wakefield MJ.   +21 more
europepmc   +1 more source

Protocol for establishing inducible CRISPR interference system for multiple-gene silencing in human pluripotent stem cells. [PDF]

STAR Protoc
Matsui S, Shiley JR, Granitto M, Ludwig K, Buckley M, Koigi S, Mirizio G, Hu YC, Mayhew CN, Iwafuchi M.   +9 more
europepmc   +1 more source

An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non‐heading Chinese Cabbage

Advanced Science, EarlyView.
CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren   +10 more
wiley   +1 more source

RAB18 regulates extrahepatic siRNA-mediated gene silencing efficacy. [PDF]

Mol Ther Nucleic Acids
Lu J, Lee J, Yuan E, Wakefield DL, Kanke M, Pruitt D, Barreda J, Rulifson IC, Xie J, Ferbas J, Long J, Meade B, Homann O, Guo W, Gomes T, Zhou H, Wu B, Cui J, Wang S.   +18 more
europepmc   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Correction: INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF‑β signaling pathway activation. [PDF]

J Orthop Surg Res
Zhang H, Huang Y, Wen Q, Li Y, Guo L, Ge N.   +5 more
europepmc   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Advancing RNAi-Based Strategies Against Downy Mildews: Insights Into dsRNA Uptake and Gene Silencing

Göl D, Okechukwu E, Ünal G, Webb A, Woods T, Hong Y, Sherif SM, Wacker T, Studholme DJ, McDowell JM, Tör M.   +10 more
europepmc   +1 more source

Sarcoglycans Role in Actin Cytoskeleton Dynamics and Cell Adhesion of Human Articular Chondrocytes: New Insights from siRNA-Mediated Gene Silencing. [PDF]

Int J Mol Sci
Centofanti A, Runci Anastasi M, Nicita F, Labellarte D, Scuruchi M, Pantano A, Freni J, Favaloro A, Vermiglio G.   +8 more
europepmc   +1 more source