Results 231 to 240 of about 7,554,622 (397)

Engineered microRNA scaffolds for potent gene silencing in vivo. [PDF]

Sci Rep
Militello G, Greig A, Bi C, Vasileva A, Zavodszky MI, Lo SC, Guilmette E, Clarner P, Liu B, Bhat G, Suh J, Dow L, Zuber J, Fellmann C, Premsrirut PK.   +14 more
europepmc   +1 more source

Small Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 Gene

, 2006
Jie Chen, Xiao-Xia Yang, Min Huang, Zeping Hu, Ming He, Wei Duan, Eli Chan, Fwu‐Shan Sheu, Xiao Chen, Shu-Feng Zhou   +9 more
openalex   +2 more sources

ERH: a plug‐and‐play protein important for gene silencing and cell cycle progression

, 2022
Marc Graille
openalex   +2 more sources

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

A sweet barrier to gene silencing: Glucose metabolism interferes with antisense oligonucleotide therapy. [PDF]

Mol Ther Nucleic Acids
Duan S, Zhang W, Cao H.
europepmc   +1 more source

Silencing of B cell activation factor gene and its implication in treating autoimmune arthritis

, 2007
Yan-kai Lin
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Evaluation of Peptide Nucleic Acid Encapsulation in Ferritin Nanocages for Gene Silencing Applications. [PDF]

Biomacromolecules
Falanga AP, Farina MV, Cianfoni G, Barolo L, Di Meo C, Borsatti GE, Ghirga F, Botta B, Pisano L, Borbone N, D'Errico S, Paone A, Oliviero G, Quaglio D, Baiocco P.   +14 more
europepmc   +1 more source

GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer

, 2003
Yoshimitsu Akiyama, Neil Watkins, Hiromu Suzuki, Kam-Wing Jair, Manon van Engeland, Manel Esteller, H Sakai, Chun-Yan Ren, Yasuhito Yuasa, James G. Herman, Stephen B. Baylin   +10 more
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source