Results 1 to 10 of about 11,640,103 (361)

Gene Targeting in Disease Networks [PDF]

Frontiers in Genetics, 2021
Profiling of whole transcriptomes has become a cornerstone of molecular biology and an invaluable tool for the characterization of clinical phenotypes and the identification of disease subtypes. Analyses of these data are becoming ever more sophisticated
Deborah Weighill, Marouen Ben Guebila, Kimberly Glass, Kimberly Glass, Kimberly Glass, John Platig, John Platig, Jen Jen Yeh, John Quackenbush, John Quackenbush   +9 more
doaj   +8 more sources

Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics

Frontiers in Molecular Neuroscience, 2022
The striatum is involved in action selection, and its disturbance can cause movement disorders. Here, we show that leucine-rich repeats and transmembrane domain 2 (Lrtm2) controls protein sorting in striatal projection systems, and its deficiency causes ...
Misato Ichise, Misato Ichise, Kazuto Sakoori, Kei-ichi Katayama, Naoko Morimura, Kazuyuki Yamada, Hiroki Ozawa, Hayato Matsunaga, Minoru Hatayama, Minoru Hatayama, Jun Aruga, Jun Aruga   +11 more
doaj   +1 more source

CRISPR/Cas9-Mediated Multi-Allelic Gene Targeting in Sugarcane Confers Herbicide Tolerance

Frontiers in Genome Editing, 2021
Sugarcane is the source of 80% of the sugar and 26% of the bioethanol produced globally. However, its complex, highly polyploid genome (2n = 100 – 120) impedes crop improvement. Here, we report efficient and reproducible gene targeting (GT) in sugarcane,
Mehmet Tufan Oz, Mehmet Tufan Oz, Angelika Altpeter, Ratna Karan, Aldo Merotto, Fredy Altpeter, Fredy Altpeter   +6 more
doaj   +1 more source

Gene Targeting

Definitions, 2020
A technique that involves integration of an exogenous DNA sequence encoding a specific gene into the genome of an organism by homologous recombination.

semanticscholar   +1 more source

KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility

FASEB BioAdvances, 2021
Epigenetic alterations of chromatin structure affect chromatin accessibility and collaborate with genetic alterations in the development of cancer. Lysine demethylase 4B (KDM4B) has been identified as a JmjC domain‐containing epigenetic modifier that ...
Takeshi Ueda, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada   +7 more
doaj   +1 more source

Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing

Nature Nanotechnology, 2020
CRISPR–Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that
Qiang Cheng, Tuo Wei, Lukas Farbiak, Lindsay T. Johnson, Sean A. Dilliard, D. Siegwart   +5 more
semanticscholar   +1 more source

Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities

JOR Spine, 2023
There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a ...
Ze‐Yu Lu, Peng‐Bo Chen, Qing‐Yin Xu, Bo Li, Sheng‐Dan Jiang, Lei‐Sheng Jiang, Xin‐Feng Zheng   +6 more
doaj   +1 more source

CRISPR/Cas9-mediated gene targeting in Arabidopsis using sequential transformation

Nature Communications, 2018
Homologous recombination-based gene targeting is a powerful tool for precise genome modification and has been widely used in organisms ranging from yeast to higher organisms such as Drosophila and mouse.
D. Miki, Wenxin Zhang, Wenjie Zeng, Zhengyan Feng, Jian‐Kang Zhu   +4 more
semanticscholar   +1 more source

Efficient in planta gene targeting in tomato using geminiviral replicons and the CRISPR/Cas9 system.

The Plant Journal, 2018
Current breeding relies mostly on random mutagenesis and recombination to generate novel genetic variation. However, targeted genome editing is becoming an increasingly important tool for precise plant breeding.
Tal Dahan-Meir, Shdema Filler-Hayut, C. Melamed-Bessudo, S. Bocobza, H. Czosnek, A. Aharoni, A. Levy   +6 more
semanticscholar   +1 more source

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
doaj   +1 more source