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Establishment of a stable transfection and gene targeting system in Babesia divergens [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Babesia divergens is an emerging tick-borne pathogen considered as the principal causative agent of bovine babesiosis in Europe with a notable zoonotic risk to human health. Despite its increasing impact, considerable gaps persist in our understanding of
Eliana F. G. Cubillos +9 more
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Gene Targeting in Disease Networks [PDF]
Frontiers in Genetics, 2021 Profiling of whole transcriptomes has become a cornerstone of molecular biology and an invaluable tool for the characterization of clinical phenotypes and the identification of disease subtypes. Analyses of these data are becoming ever more sophisticated
Deborah Weighill +9 more
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CRISPR/Cas9-Mediated Multi-Allelic Gene Targeting in Sugarcane Confers Herbicide Tolerance
Frontiers in Genome Editing, 2021 Sugarcane is the source of 80% of the sugar and 26% of the bioethanol produced globally. However, its complex, highly polyploid genome (2n = 100 – 120) impedes crop improvement. Here, we report efficient and reproducible gene targeting (GT) in sugarcane,
Mehmet Tufan Oz +6 more
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Frontiers in Molecular Neuroscience, 2022 The striatum is involved in action selection, and its disturbance can cause movement disorders. Here, we show that leucine-rich repeats and transmembrane domain 2 (Lrtm2) controls protein sorting in striatal projection systems, and its deficiency causes ...
Misato Ichise +11 more
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JOR Spine, 2023 There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a ...
Ze‐Yu Lu +6 more
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Therapeutic gene targeting [PDF]
Gene Therapy, 1998 Gene targeting is the use of homologous recombination to make defined alterations to the genome. One of the possible outcomes of gene targeting is the accurate correction of genetic defects, and this would make it the ideal method of gene therapy for single gene disorder.
R J, Yáñez, A C, Porter
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Gene targeting in plants [PDF]
The EMBO Journal, 1987 Although the generation of transgenic plants is now routine, the integration of foreign genetic information has so far been at random sites in the genome. We now present evidence for directed integration into a predicted location in the host plant genome.
J, Paszkowski +3 more
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T-Gene: improved target gene prediction [PDF]
Bioinformatics, 2019 Abstract Motivation Identifying the genes regulated by a given transcription factor (TF) (its ‘target genes’) is a key step in developing a comprehensive understanding of gene regulation. Previously, we developed a method (CisMapper) for predicting the target genes of a TF based solely on the ...
Timothy O’Connor +3 more
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KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility
FASEB BioAdvances, 2021 Epigenetic alterations of chromatin structure affect chromatin accessibility and collaborate with genetic alterations in the development of cancer. Lysine demethylase 4B (KDM4B) has been identified as a JmjC domain‐containing epigenetic modifier that ...
Takeshi Ueda +7 more
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Frontiers in Aging Neuroscience, 2023 IntroductionHuntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT).
Yongcheng Pan +9 more
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