Results 181 to 190 of about 1,756,365 (358)

Supplementary Material for: The EFEMP1 Gene: A Frequent Target for Epigenetic Silencing in Multiple Human Pituitary Adenoma Subtypes

, 2017
Cathy Duong, Kiren Yacqub‐Usman, Richard D. Emes, Richard N. Clayton, William E. Farrell   +4 more
openalex   +1 more source

Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway. [PDF]

Immunol Rev, 2023
Dreismann AK, Hallam TM, Tam LC, Nguyen CV, Hughes JP, Ellis S, Harris CL.   +6 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells. [PDF]

Sci Rep, 2022
Bäckström A, Yudovich D, Žemaitis K, Nilsén Falck L, Subramaniam A, Larsson J.   +5 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Hypothetical Genetic Strategy to Eliminate All Types of Viruses Using Self-Destructive Gene Integration (Targeting RNA and DNA Viruses)

Mahmoud Elsayed Ali saleh
openalex   +1 more source

Spatial Control of Gene Expression by Nanocarriers Using Heparin Masking and Ultrasound-Targeted Microbubble Destruction

, 2016
Beata Chertok, Róbert Langer, Daniel G. Anderson   +2 more
openalex   +1 more source

Bioinformatics driven in gene targeting platform for gold anticancer strategy delivery. [PDF]

Mater Today Bio
Jiang C, Wen H, Chen J, Han N, Sun X, Zhang Y, Hu Y, Shu G, Yin G, Wang M.   +9 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Scatter plot comparing the signal to noise ratio (S/N) of SpotXel reader and microplate reader (OD 655nm) (y-axis) with cDDLAMP target genes eae, stx1, and stx2 (x-axis).

Alaa H. Sewid (7027025), Joseph H. Ramos (21169019), Haley C. Dylewski (21169022), Gillian I. Castro (21169025), Doris H. D’Souza (10717233), Shigetoshi Eda (508134)   +5 more
openalex   +1 more source