Results 181 to 190 of about 12,260,520 (401)

Visceral targets specify calcitonin gene-related peptide and substance P enrichment in trigeminal afferent projections [PDF]

, 1992
Kieran Horgan, Derek van der Kooy
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Inactivation of the SGS1 and EXO1 Genes Synergistically Stimulates Plasmid Integration in Yeast

Food Technology and Biotechnology, 2005
Different procedures used for targeted genetic manipulations are based on homologous recombination between chromosomal and exogenous DNA. A double-strand break (DSB) present on the plasmid molecule stimulates and directs plasmid integration to the ...
Anamarija Štafa, Ivan-Krešimir Svetec, Zoran Zgaga   +2 more
doaj  

Retargeting of pre-set regions on chromosome for high gene expression in mammalian cells [PDF]

, 2005
We have developed a system to hunt and reuse special gene integration sites that allow for high and stable gene expression. A vector, named pRGFP8, was constructed. The plasmid pRGFP8 contains a reporter gene, gfp2 and two extraneous DNA fragments.
Chang, Christine, Jiao, Peng, Kral, Kelly, Rogg, Jonathan, Wang, Daniel I.C., Wyhs, Nicolas   +5 more
core  

Rapid detection of infectious laryngotracheitis virus by standardization of polymerase chain reaction targeting a relatively conserved region of the thymidine kinase gene

, 1970
Shovon Chakma, Subir Sarker, Saranika Talukder, Md. Hakimul Haque, EH Chowdhury, ASM Bari   +5 more
openalex   +2 more sources

GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. [PDF]

, 1994
A L Wu, W. Scott Moye‐Rowley
openalex   +1 more source

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

Nature, 2016
D. Dever, R. Bak, A. Reinisch, J. Camarena, Gabriel Washington, Carmencita E. Nicolas, Mara Pavel-Dinu, Nivi Saxena, Alec B. Wilkens, Sruthi Mantri, N. Uchida, Ayal Hendel, A. Narla, R. Majeti, K. Weinberg, M. Porteus   +15 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Two target sites for protein binding in the promoter region of a cell cycle regulated human H1 histone gene

, 1988
André J. van Wijnen, Kenneth L. Wright, Robert F. Massung, Martijn Gerretsen, Janet L. Stein, Gary S. Stein   +5 more
openalex   +1 more source

High‐efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9

The Plant Journal, 2017
J. Gil‐Humanes, Yanpeng Wang, Zhen Liang, Qi-wei Shan, Carmen V. Ozuna, Susana Sánchez-León, N. Baltes, Colby G. Starker, F. Barro, Caixia Gao, D. Voytas   +10 more
semanticscholar   +1 more source