Results 181 to 190 of about 12,501,640 (402)

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Targeting Genes: Delivery and Persistent Expression of a Foreign Gene Driven by Mammalian Regulatory Elements in Vivo

, 1989
Catherine H. Wu, James M. Wilson, George Y. Wu   +2 more
openalex   +1 more source

High‐efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9

The Plant Journal, 2017
J. Gil‐Humanes, Yanpeng Wang, Zhen Liang, Qi-wei Shan, Carmen V. Ozuna, Susana Sánchez-León, N. Baltes, Colby G. Starker, F. Barro, Caixia Gao, D. Voytas   +10 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Spatiotemporal gene targeting in the mouse corneal endothelium. [PDF]

Taiwan J Ophthalmol, 2023
Lee J, Heur M.
europepmc   +1 more source

In Situ Distinction between Steroid Receptor Binding and Transactivation at a Target Gene [PDF]

, 1991
Donald P. McDonnell, Zafar Nawaz, Bert W. O’Malley   +2 more
openalex   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. [PDF]

, 1991
Beverly H. Koller, H S Kim, A M Latour, Kristen K. Brigman, R C Boucher, Peter Scambler, Brandon J. Wainwright, O. Smithies   +7 more
openalex   +3 more sources

Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration. [PDF]

iScience, 2023
Wu DD, Salah YA, Ngowi EE, Zhang YX, Khattak S, Khan NH, Wang Y, Li T, Guo ZH, Wang YM, Ji XY.   +10 more
europepmc   +1 more source

Targeting gene expression to specific cardiovascular cell types in transgenic mice. [PDF]

, 1993
John Hunter, Hong Zhu, K J Lee, S. Kubalak, Kenneth R. Chien   +4 more
openalex   +1 more source