Results 181 to 190 of about 1,756,365 (358)

Supplementary Material for: The EFEMP1 Gene: A Frequent Target for Epigenetic Silencing in Multiple Human Pituitary Adenoma Subtypes

open access: gold, 2017
Cathy Duong   +4 more
openalex   +1 more source

Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway. [PDF]

open access: yesImmunol Rev, 2023
Dreismann AK   +6 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells. [PDF]

open access: yesSci Rep, 2022
Bäckström A   +5 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Bioinformatics driven in gene targeting platform for gold anticancer strategy delivery. [PDF]

open access: yesMater Today Bio
Jiang C   +9 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Scatter plot comparing the signal to noise ratio (S/N) of SpotXel reader and microplate reader (OD 655nm) (y-axis) with cDDLAMP target genes eae, stx1, and stx2 (x-axis).

open access: green
Alaa H. Sewid (7027025)   +5 more
openalex   +1 more source

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