Results 21 to 30 of about 1,756,365 (358)

The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction [PDF]

open access: yes, 2016
Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive ...
Albahrani, M   +5 more
core   +2 more sources

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

open access: yesNature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
HaoRan Tang   +12 more
doaj   +1 more source

Transposon variants and their effects on gene expression in arabidopsis [PDF]

open access: yes, 2013
Transposable elements (TEs) make up the majority of many plant genomes. Their transcription and transposition is controlled through siRNAs and epigenetic marks including DNA methylation.
Smith, L.M., Wang, X., Weigel, D.
core   +3 more sources

Production and characterization of eggs from hens with ovomucoid gene mutation

open access: yesPoultry Science, 2021
Ovomucoid is a major egg white protein which is considered as the most dominant allergen in chicken eggs. Owing to the difficulty of separating ovomucoid from egg whites, researchers have adopted genetic deletion for development of hypoallergenic eggs ...
Takehiro Mukae   +4 more
doaj   +1 more source

CRISPR-Cas9-mediated functional dissection of 3'-UTRs. [PDF]

open access: yes, 2017
Many studies using reporter assays have demonstrated that 3' untranslated regions (3'-UTRs) regulate gene expression by controlling mRNA stability and translation.
Ahituv, Nadav   +6 more
core   +1 more source

A PCA3 gene-based transcriptional amplification system targeting primary prostate cancer. [PDF]

open access: yes, 2015
Targeting specifically primary prostate cancer (PCa) cells for immune therapy, gene therapy or molecular imaging is of high importance. The PCA3 long non-coding RNA is a unique PCa biomarker and oncogene that has been widely studied.
Fradet, Yves   +5 more
core   +5 more sources

CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

open access: yesViruses, 2018
Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level.
Shuliang Chen, Xiao Yu, Deyin Guo
doaj   +1 more source

Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives

open access: yesFrontiers in Oncology, 2023
Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
doaj   +1 more source

Targeted insertion of large DNA sequences by homology‐directed repair or non‐homologous end joining in engineered tobacco BY‐2 cells using designed zinc finger nucleases

open access: yesPlant Direct, 2019
Targeted integration of recombinant DNA fragments into plant genomes by DNA double‐strand break (DSB) repair mechanisms has become a powerful tool for precision engineering of crops.
Andreas Schiermeyer   +17 more
doaj   +1 more source

Chimeric nucleases stimulate gene targeting in human cells [PDF]

open access: yes, 2002
Gene targeting is a powerful technique to introduce genetic change into the genome of eukaryotic cells. It is widely used to create defined mutations in murine embryonic stem cells and theoretically could be used to create or repair mutations in ...
Baltimore, David, Porteus, Matthew
core   +2 more sources

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