Results 21 to 30 of about 1,630,164 (254)

Design of double-walled carbon nanotubes for biomedical applications [PDF]

open access: yes, 2012
Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M.   +8 more
core   +2 more sources

CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

open access: yesViruses, 2018
Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level.
Shuliang Chen, Xiao Yu, Deyin Guo
doaj   +1 more source

Enhancing HR Frequency for Precise Genome Editing in Plants

open access: yesFrontiers in Plant Science, 2022
Gene-editing tools, such as Zinc-fingers, TALENs, and CRISPR-Cas, have fostered a new frontier in the genetic improvement of plants across the tree of life.
Hao Chen   +4 more
doaj   +1 more source

Chimeric nucleases stimulate gene targeting in human cells [PDF]

open access: yes, 2002
Gene targeting is a powerful technique to introduce genetic change into the genome of eukaryotic cells. It is widely used to create defined mutations in murine embryonic stem cells and theoretically could be used to create or repair mutations in ...
Baltimore, David, Porteus, Matthew
core   +2 more sources

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model

open access: yesFrontiers in Aging Neuroscience, 2023
IntroductionHuntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT).
Yongcheng Pan   +9 more
doaj   +1 more source

Retargeted adenoviruses for radiation-guided gene delivery [PDF]

open access: yes, 2016
The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells.
A Beetz   +54 more
core   +2 more sources

Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives

open access: yesFrontiers in Oncology, 2023
Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
doaj   +1 more source

The magnetofection method: Using magnetic force to enhance gene delivery [PDF]

open access: yes, 2003
In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles.
Alexiou C.   +10 more
core   +3 more sources

In planta gene targeting [PDF]

open access: yesProceedings of the National Academy of Sciences, 2012
The development of designed site-specific endonucleases boosted the establishment of gene targeting (GT) techniques in a row of different species. However, the methods described in plants require a highly efficient transformation and regeneration procedure and, therefore, can be applied to very few species.
Fauser, Friedrich   +6 more
openaire   +4 more sources

Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast

open access: yesG3: Genes, Genomes, Genetics, 2019
Precise allele replacement (genome editing), without unwanted changes to the genome, provides a powerful tool to define the functions of DNA elements and encoded factors in their normal biological context.
Aaron J. Storey   +4 more
doaj   +1 more source

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