Results 21 to 30 of about 708,347 (229)
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Nature Communications, 2017 Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang +12 more
doaj +1 more source
Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis. [PDF]
, 2019 The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation to control gene expression.
Chory, Joanne +9 more
core +2 more sources
Enhancing HR Frequency for Precise Genome Editing in Plants
Frontiers in Plant Science, 2022 Gene-editing tools, such as Zinc-fingers, TALENs, and CRISPR-Cas, have fostered a new frontier in the genetic improvement of plants across the tree of life.
Hao Chen +4 more
doaj +1 more source
A Novel Anticlustering Filtering Algorithm for the Prediction of Genes as a Drug Target [PDF]
American Journal of Biomedical Engineering 2012, 2(5):206-211, 2012 The high-throughput data generated by microarray experiments provides complete set of genes being expressed in a given cell or in an organism under particular conditions. The analysis of these enormous data has opened a new dimension for the researchers.
arxiv +1 more source
Design of double-walled carbon nanotubes for biomedical applications [PDF]
, 2012 Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functionalized in such a way that they were optimally designed as a nano-vector for the delivery of small interfering RNA (siRNA), which is of great interest for
Coley, Helen M. +8 more
core +2 more sources
Frontiers in Aging Neuroscience, 2023 IntroductionHuntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT).
Yongcheng Pan +9 more
doaj +1 more source
Essentiality, conservation, evolutionary pressure and codon bias in bacterial genes [PDF]
Gene 663, 178-188 (2018), 2017 Essential genes constitute the core of genes which cannot be mutated too much nor lost along the evolutionary history of a species. Natural selection is expected to be stricter on essential genes and on conserved (highly shared) genes, than on genes that are either nonessential or peculiar to a single or a few species.
arxiv +1 more source
Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives
Frontiers in Oncology, 2023 Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
doaj +1 more source
Journal of Fungi, 2023 Gene targeting is a commonly used method to reveal the function of genes. Although it is an attractive tool for molecular studies, it can frequently be a challenge because its efficiency can be low and it requires the screening of a large number of ...
Lajos Acs-Szabo +3 more
doaj +1 more source
Genes predisposing to syndromic and nonsyndromic infertility: a narrative review [PDF]
arXiv, 2021 Background: Advanced biological techniques have helped produce more insightful findings on the genetic etiology of infertility that may lead to better management of the condition. This review provides an update on genes predisposing to syndromic and nonsyndromic infertility.
arxiv