Results 1 to 10 of about 7,141,959 (344)

General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels. [PDF]

open access: yesPLoS ONE, 2018
General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets.
Jun-Ichi Kishikawa   +7 more
doaj   +3 more sources

Lasting effects of general anesthetics on the brain in the young and elderly: “mixed picture” of neurotoxicity, neuroprotection and cognitive impairment [PDF]

open access: yesJournal of Anesthesia, 2019
General anesthetics are commonly used in major surgery. To achieve the depth of anesthesia for surgery, patients are being subjected to a variety of general anesthetics, alone or in combination.
Jan Michiels, Hailin Zhao, Daqing Ma
exaly   +3 more sources

Effect of Local and General Anesthetics on Interfacial Water. [PDF]

open access: yesPLoS ONE, 2016
Water undergoes structural change as it interfaces with hydrophilic surfaces, including the many hydrophilic surfaces within the cell. This interfacial water has become known as "Exclusion Zone (EZ) water" or "fourth-phase water" [1].We tested the ...
Nenad Kundacina   +2 more
doaj   +3 more sources

Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]

open access: yesBiophysical Journal, 2013
A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated ion channels.
Gray, Ellyn   +3 more
arxiv   +5 more sources

The Potential Effect of General Anesthetics in Cancer Surgery: Meta-Analysis of Postoperative Metastasis and Inflammatory Cytokines. [PDF]

open access: yesCancers (Basel), 2023
Simple Summary This meta-analysis examined the effect of general anesthetics on metastasis and recurrence after cancer surgery from clinical and pre-clinical studies.
Li R   +7 more
europepmc   +2 more sources

The role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction

open access: yesNeural Regeneration Research, 2017
Postoperative cognitive dysfunction (POCD) is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and ...
Marco Cascella, Sabrina Bimonte
doaj   +3 more sources

Effects of General Anesthetics on Synaptic Transmission and Plasticity. [PDF]

open access: yesCurr Neuropharmacol, 2022
General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission principally by modulating the function of glutamatergic or GABAergic synapses, respectively, with relative anesthetic agent-specific mechanisms.
Platholi J, Hemmings HC.
europepmc   +2 more sources

Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics. [PDF]

open access: yesInt J Mol Sci, 2022
General anesthetics mainly act by modulating synaptic inhibition on the one hand (the potentiation of GABA transmission) or synaptic excitation on the other (the inhibition of NMDA receptors), but they can also have effects on numerous other proteins ...
Timic Stamenic T, Todorovic SM.
europepmc   +2 more sources

Identifying c-fos Expression as a Strategy to Investigate the Actions of General Anesthetics on the Central Nervous System. [PDF]

open access: yesCurr Neuropharmacol, 2022
Although general anesthetics have been used in the clinic for more than 170 years, the ways in which they induce amnesia, unconsciousness, analgesia, and immobility remain elusive.
Zhang D, Liu J, Zhu T, Zhou C.
europepmc   +2 more sources

General Anesthetics in Cancer Surgery: Can Anesthesiologists Help the Patient with More than a Safe Sleep [PDF]

open access: yesMedicina, 2022
Most patients suffering from neoplastic diseases will at some point during their illness be approached surgically. Surgery itself may be unfortunately responsible for tumor proliferation and metastatic spread.
John Michael Bonvini
doaj   +2 more sources

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