General Anesthetics in Cancer Surgery: Can Anesthesiologists Help the Patient with More than a Safe Sleep [PDF]
Medicina, 2022 Most patients suffering from neoplastic diseases will at some point during their illness be approached surgically. Surgery itself may be unfortunately responsible for tumor proliferation and metastatic spread.
John Michael Bonvini
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How general anesthetics work: from the perspective of reorganized connections within the brain [PDF]
Korean Journal of Anesthesiology, 2022 General anesthesia is critical for various procedures and surgeries. Despite the widespread use of anesthetics, their precise mechanisms remain poorly understood.
Teo Jeon Shin +2 more
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General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics [PDF]
PharmaceuticalsThe introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková +2 more
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Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review [PDF]
Frontiers in Synaptic Neuroscience, 2022 General anesthetics disrupt brain processes involved in consciousness by altering synaptic patterns of excitation and inhibition. In the cerebral cortex and hippocampus, GABAergic inhibition is largely mediated by inhibitory interneurons, a heterogeneous
Iris A. Speigel +2 more
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High-Loading Self-Assembling Peptide Nanoparticles as a Lipid-Free Carrier for Hydrophobic General Anesthetics [PDF]
International Journal of Nanomedicine, 2021 Jing Liu,1,2 Fei Peng,1,2 Yi Kang,1,2 Deying Gong,1,2 Jing Fan,1,2 Wensheng Zhang,1,2 Feng Qiu1,2 1Laboratory of Anesthesia and Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital, Sichuan ...
Liu J +6 more
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General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels. [PDF]
PLoS ONE, 2018 General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets.
Jun-Ichi Kishikawa +7 more
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Randomized controlled trial of the effect of general anesthetics on postoperative recovery after minimally invasive nephrectomy [PDF]
Korean Journal of AnesthesiologyBackground General anesthetic techniques can affect postoperative recovery. We compared the effect of propofol-based total intravenous anesthesia (TIVA) and desflurane anesthesia on postoperative recovery.
Hyun-Kyu Yoon +5 more
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Effect of Local and General Anesthetics on Interfacial Water. [PDF]
PLoS ONE, 2016 Water undergoes structural change as it interfaces with hydrophilic surfaces, including the many hydrophilic surfaces within the cell. This interfacial water has become known as "Exclusion Zone (EZ) water" or "fourth-phase water" [1].We tested the ...
Nenad Kundacina +2 more
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Editorial: Neural circuits underlying general anesthetics mediated consciousness changes [PDF]
Frontiers in Neural Circuits, 2023 Cheng Zhou
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Understanding the Molecular Mechanism of Anesthesia: Effect of General Anesthetics and Structurally Similar Non-Anesthetics on the Properties of Lipid Membranes. [PDF]
J Phys Chem B, 2023 Rózsa ZB +4 more
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