Results 1 to 10 of about 7,083,000 (278)
General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels. [PDF]
PLoS ONE, 2018 General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets.
Jun-Ichi Kishikawa +7 more
doaj +3 more sources
Effect of Local and General Anesthetics on Interfacial Water. [PDF]
PLoS ONE, 2016 Water undergoes structural change as it interfaces with hydrophilic surfaces, including the many hydrophilic surfaces within the cell. This interfacial water has become known as "Exclusion Zone (EZ) water" or "fourth-phase water" [1].We tested the ...
Nenad Kundacina +2 more
doaj +3 more sources
Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]
Biophysical Journal, 2013 A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated ion channels.
Gray, Ellyn +3 more
arxiv +5 more sources
Neural Regeneration Research, 2017 Postoperative cognitive dysfunction (POCD) is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and ...
Marco Cascella, Sabrina Bimonte
doaj +3 more sources
Mechanisms of action of general anesthetics
Frontiers in Bioscience - Landmark, 2014 Since William Morton successfully demonstrated the use of inhaled ether for surgical anesthesia in 1846, the development of new anesthetics and safe general anesthesia techniques have contributed greatly to the advancement of surgery and other invasive procedures. However, the underlying neurocellular mechanisms by which the state of general anesthesia
F Ellinghaus
exaly +5 more sources
Effects of General Anesthetics on Synaptic Transmission and Plasticity. [PDF]
Curr Neuropharmacol, 2022 General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission principally by modulating the function of glutamatergic or GABAergic synapses, respectively, with relative anesthetic agent-specific mechanisms.
Platholi J, Hemmings HC.
europepmc +2 more sources
Effect of general anesthetics on the developing brain
Journal of Anaesthesiology Clinical Pharmacology, 2012 Studies on rodents and subhuman primates suggest that prolonged exposure to general anesthetics may induce widespread neuronal cell death and neurological sequelae; seriously questioning the safety of pediatric anesthesia.
S Velayudha Reddy
doaj +5 more sources
General Anesthetics in Cancer Surgery: Can Anesthesiologists Help the Patient with More than a Safe Sleep [PDF]
Medicina, 2022 Most patients suffering from neoplastic diseases will at some point during their illness be approached surgically. Surgery itself may be unfortunately responsible for tumor proliferation and metastatic spread.
John Michael Bonvini
doaj +2 more sources
Lasting effects of general anesthetics on the brain in the young and elderly: “mixed picture” of neurotoxicity, neuroprotection and cognitive impairment [PDF]
Journal of Anesthesia, 2019 Jan Michiels, Hailin Zhao, Daqing Ma
exaly +3 more sources
The thermodynamics of general and local anesthesia [PDF]
Biophys. J. 2014, 106: 2143-2156, 2014 General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare +2 more
arxiv +4 more sources