Results 1 to 10 of about 5,293,329 (99)
Theory in Biosciences, 2008 In order to describe a cell at molecular level, a notion of a "gene" is neither necessary nor helpful. It is sufficient to consider the molecules (i.e., chromosomes, transcripts, proteins) and their interactions to describe cellular processes. The downside of the resulting high resolution is that it becomes very tedious to address features on the ...
Prohaska, Sonja J., Stadler, Peter F.
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Genome Biology, 2002 BackgroundGene-expression analysis is increasingly important in biological research, with real-time reverse transcription PCR (RT-PCR) becoming the method of choice for high-throughput and accurate expression profiling of selected genes.
J. Vandesompele +6 more
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Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics
, 1990 Comparative studies of the nucleotide sequences of ribosomal RNA (rRNA) genes provide a means for analyzing phylogenetic relation ships over a wide range of taxonomic levels (Woese and Olsen 1986; Zimmer et al 1988; Medlin et al 1988; Jorgensen and ...
T. White
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Identification of acquired antimicrobial resistance genes
Journal of Antimicrobial Chemotherapy, 2012 Objectives Identification of antimicrobial resistance genes is important for understanding the underlying mechanisms and the epidemiology of antimicrobial resistance.
E. Zankari +7 more
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RNAmmer: consistent and rapid annotation of ribosomal RNA genes
Nucleic Acids Research, 2007 The publication of a complete genome sequence is usually accompanied by annotations of its genes. In contrast to protein coding genes, genes for ribosomal RNA (rRNA) are often poorly or inconsistently annotated.
K. Lagesen +5 more
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Analysis of Gene‐Gene Interactions [PDF]
Current Protocols in Human Genetics, 2011 AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
Diane, Gilbert-Diamond, Jason H, Moore
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Cancer Research, 2004 Accurate normalization is an absolute prerequisite for correct measurement of gene expression. For quantitative real-time reverse transcription-PCR (RT-PCR), the most commonly used normalization strategy involves standardization to a single ...
C. Andersen, J. L. Jensen, T. Ørntoft
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GEIRA: gene-environment and gene–gene interaction research application [PDF]
European Journal of Epidemiology, 2011 The GEIRA (Gene-Environment and Gene-Gene Interaction Research Application) algorithm and subsequent program is dedicated to genome-wide gene-environment and gene-gene interaction analysis. It implements concepts of both additive and multiplicative interaction as well as calculations based on dominant, recessive and co-dominant genetic models ...
Ding, Bo +4 more
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Omnibus testing approach for gene‐based gene‐gene interaction
Statistics in Medicine, 2022 AbstractGenetic interaction is considered as one of the main heritable component of complex traits. With the emergence of genome‐wide association studies (GWAS), a collection of statistical methods dedicated to the identification of interaction at the SNP level have been proposed.
Hébert, Florian +2 more
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Gene Complexity and Gene Duplicability [PDF]
Current Biology, 2005 Eukaryotic genes are on average more complex than prokaryotic genes in terms of expression regulation, protein length, and protein-domain structure [1-5]. Eukaryotes are also known to have a higher rate of gene duplication than prokaryotes do [6, 7]. Because gene duplication is the primary source of new genes [], the average gene complexity in a genome
He, Xionglei, Zhang, Jianzhi
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