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Purification of the Adenomatous Polyposis Coli (APC) Gene Product
Archives of Biochemistry and Biophysics, 1995Mutation of the adenomatous polyposis coli (APC) gene is responsible for familial adenomatous polyposis and is an etiologic factor for digestive tract malignancies. Although the APC gene product (APC) is believed to play a role in growth suppression of colonocytes, the underlying mechanism is not clear. However, recent evidence does suggest that APC is
G, Bhattacharya +3 more
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Brain metastases exhibit gross deletions of the APC gene
Brain Tumor Pathology, 2011Candidate genes involved in metastasis to the brain require investigation. In the present study, the adenomatous polyposis coli (APC) gene was analyzed in a set of human brain metastases. Gross deletions of the APC gene were tested by polymerase chain reaction/loss of heterozygosity (LOH) using the restriction fragment length polymorphism method ...
Pećina-Šlaus, Nives +3 more
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APC Gene Expression in Gastric Carcinoma: An Immunohistochemical Study
Applied Immunohistochemistry & Molecular Morphology, 2002Gastric carcinoma is one of the most common malignancies worldwide, particularly in Japan and China. Inactivation of the adenomatous polyposis coli ( ) gene, a tumor suppressor gene, has been shown to play a significant role in the development of colorectal carcinoma, and it has been suggested that it may play a role throughout the digestive tract ...
A, Grace +6 more
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Different Expressivity of two Adjacent Mutations of the APC Gene
Tumori Journal, 1999Aims and background The phenotypic expression of different APC mutations in familial adenomatous polyposis (FAP) is variable: two to three variants of the disease have been defined based on the severity of colonic manifestations. Age of onset and number of polypectomies per person-year of postsurgical follow-up were compared in two FAP families with ...
PRESCIUTTINI, SILVANO +11 more
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Nihon rinsho. Japanese journal of clinical medicine, 1996
The tumor suppressor gene APC is mutated in most cases of familial adenomatous polyposis (FAP) and sporadic colorectal tumors. The product of the APC gene is a 300 kDa protein present in the cytoplasm as a homodimer. Interestingly, the APC protein is known to interact with the adherence junction protein catenin, suggesting that APC may be involved in ...
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The tumor suppressor gene APC is mutated in most cases of familial adenomatous polyposis (FAP) and sporadic colorectal tumors. The product of the APC gene is a 300 kDa protein present in the cytoplasm as a homodimer. Interestingly, the APC protein is known to interact with the adherence junction protein catenin, suggesting that APC may be involved in ...
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Study of the APC gene function in the mouse APC+/APC1638N model.
Neuro endocrinology letters, 2016Familial adenomatous polyposis (FAP) is an autosomal dominant disease characterized by the presence of hundreds to thousands of benign polyps in the colon. If not removed prophylactically they represent a risk of developing malignant cancer with an almost 100% penentrance. FAP is induced by germline mutation in the APC gene.
Zuzana, Adamcikova +10 more
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The APC gene product and colorectal carcinogenesis.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1997The adenomatous polyposis coli (APC) gene has been found to be mutated during the development of sporadic colorectal tumours as well as in familial adenomatous polyposis patients (FAP), mutations being somatic or germinal respectively. The gene product is truncated in the carboxyterminal region but the role of the APC protein in tumorigenesis is not ...
C, Bonneton, L, Larue, J P, Thiéry
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APC gene and molecular diagnostics
2003Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
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APC gene and presimptomatic genetic testing
2003Obiteljska adenomatozna polipoza (FAP) je autosomno dominantno nasljedna bolest povezana s povećanim rizikom oboljevanja od karcinoma debelog crijeva. U oboljelih se tijekom drugog ili trećeg desetljeća života na sluznici debelog crijeva razvija na stotine i tisuće adenomatoznih polipa koji pokazuju veliku sklonost zloćudnoj preobrazbi.
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Identification of APC gene mutations in Italian APC patients by PCR-SSCP analysis
1993The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer. It is also implicated in the development of sporadic colorectal tumors. The characterization of APC gene mutations in APC patients is clinically important because DNA-based tests can ...
L. Varesco +22 more
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