Results 71 to 80 of about 113,876 (211)

Identification of a Preneoplastic Gene Expression Profile in Tubal Epithelium of BRCA1 Mutation Carriers

Neoplasia: An International Journal for Oncology Research, 2010
Microinvasive carcinomas and high-grade intraepithelial neoplasms are commonly discovered within the fallopian tube of BRCA1 mutation carriers at the time of risk-reducing salpingo-oophorectomy, suggesting that many BRCA1-mutated ovarian carcinomas ...
Joshua Z. Press, Kaitlyn Wurz, Barbara M. Norquist, Ming K. Lee, Christopher Pennil, Rochelle Garcia, Piri Welcsh, Barbara A. Goff, Elizabeth M. Swisher   +8 more
doaj   +1 more source

Brca1 in immunoglobulin gene conversion and somatic hypermutation [PDF]

DNA Repair, 2008
Defects in Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 was previously implicated in the homologous recombination pathway via effects on the assembly of recombinase Rad51. Activation-induced cytidine deaminase (AID) deaminates C to U in B lymphocyte immunoglobulin (Ig) DNA to ...
Simonne, Longerich, Brian J, Orelli, Richard W, Martin, Douglas K, Bishop, Ursula, Storb   +4 more
openaire   +2 more sources

Nationwide Study of Breast Cancer Risk Factors in Latinas [PDF]

, 2011
Breast cancer is the most common cancer among American women. Any woman can be affected by breast cancer, with risk for the disease increasing with age. Risk for breast cancer is also exacerbated in women who have certain genetic alterations.
Julie Sawitzke, Latoya Silverton, Latoya Silverton, Michael Dean   +3 more
core   +3 more sources

BRCA1 and BRCA2 mutations in Iranian breast cancer patients: A systematic review

Journal of Research in Medical Sciences, 2015
Background: BRCA1/2 genes mutation prevalence varies among ethnic groups and may be influenced by founder mutations. Understanding BRCA1/2 genes mutations is important for reducing breast cancer (BC) incidence, accurate risk assessment and counseling ...
Hossein Neamatzadeh, Seyed Mostafa Shiryazdi, Seyed Mahdi Kalantar   +2 more
doaj  

BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development. [PDF]

PLoS ONE, 2014
The assessment of BRCA1 and BRCA2 coding sequences to identify pathogenic mutations associated with inherited breast/ovarian cancer syndrome has provided a method to identify high-risk individuals, allowing them to seek preventative treatments and ...
Harriet E Feilotter, Claire Michel, Paolo Uy, Lauren Bathurst, Scott Davey   +4 more
doaj   +1 more source

CLINICAL AND MORPHOLOGICAL FEATURES OF HEREDITARY OVARIAN CANCER

Сибирский онкологический журнал, 2017
Germ-line mutations in BRCA1 and BRCA2 genes are the most established risk factors for hereditary breast and ovarian cancers. The purpose of the study was to analyze BRCA1/2 testing in ovarian cancer patients. Materials and methods.
K. B. Kotiv, T. V. Gorodnova, A. O. Ivantsov, A. G. Iyevleva, S. N. Aleksakhina, G. M. Manichas, A. S. Lisyanskaya, R. P. Salomatov, M. S. Shushaniia, M. V. Borodenko, L. D. Roman, G. I. Mikhailiuk, O. N. Mikheeva, T. G. Grigorieva, I. V. Berlev, E. N. Imyanitov, A. P. Sokolenko   +16 more
doaj   +1 more source

Frequency of BRCA1 and BRCA2 mutations in ovarian cancer patients in South-East Poland

Hereditary Cancer in Clinical Practice, 2022
Background Mutations in BRCA1 and BRCA2 genes are well-established risk factors of breast and ovarian cancer. In our former study, we observed that approximately 6% of unselected ovarian cancer patients in the region of Podkarpacie (South-East Poland ...
Andrzej Jasiewicz, Helena Rudnicka, Wojciech Kluźniak, Wojciech Gronwald, Tomasz Kluz, Cezary Cybulski, Anna Jakubowska, Jan Lubiński, Jacek Gronwald   +8 more
doaj   +1 more source

Breast Cancer Gene (BRCA1, BRCA2)

Journal of Medicine and Life Science, 2003
Most women with breast cancer do not have a familial history of the disease in a first degree relative and hereditary breast cancer caused by a mutant gene passed from parents to their children is rare; only 5-10% of breast cancers are estimated to be attributable to the inheritance of rare highly penetrant, germline mutations of genes, although this ...
openaire   +1 more source

Identification of genes induced by BRCA1 in breast cancer cells [PDF]

, 2002
Cataloged from PDF version of article.Inherited mutations of the BRCA1 gene predispose to breast, ovarian, and other cancers. The role of the BRCA1 gene in the maintenance of chromosomal integrity is linked to a number of biological properties of its ...
Aprelikova, Balint, Bochar, Borg, Borg, Bruening, Diatchenko, Harkin, Hashizume, Hirano, Kachhap, Kitagawa, Lei, MacLachlan, Miki, Monteiro, Murphy, Nasmyth, Ruffner, Schultz, Scully, Scully, Sonoda, Van’t Veer, Venkitaraman, Wang, Wang, Welcsh, Yamanaka, Zheng   +29 more
core   +1 more source

Functional characterization of BRCA1 gene variants by mini-gene splicing assay [PDF]

European Journal of Human Genetics, 2014
Mutational screening of the breast cancer susceptibility gene BRCA1 leads to the identification of numerous pathogenic variants such as frameshift and nonsense variants, as well as large genomic rearrangements. The screening moreover identifies a large number of variants, for example, missense, silent, and intron variants, which are classified as ...
Steffensen, Ane Y, Dandanell, Mette, Jønson, Lars, Ejlertsen, Bent, Gerdes, Anne-Marie, Nielsen, Finn C, Hansen, Thomas vO   +6 more
openaire   +3 more sources