Results 1 to 10 of about 142,532 (187)

Integrative Bulk and Single-Cell Transcriptomic Profiling Reveals Oxidative Stress-Related Genes and Potential Therapeutic Targets in Osteoarthritis [PDF]

Mediators of Inflammation
Osteoarthritis (OA) is increasingly recognized as a degenerative joint disease that leads to a serious problem of public health, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated bulk and single-cell RNA
Jinhui Peng, Jinzhong Chen, Duan Gao, Bowei Liang, Zongquan Huang, Bo Xiong, Shuheng Zhou, Guanghai Tan, Zhihui Zhong, Xianghong Zeng   +9 more
doaj   +2 more sources

Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis

Journal of Orthopaedic Translation
Background: The mechanism by which chondrocyte senescence aggravate OA progression has not yet been well elucidated. The aim of this study was to investigate the chondrocyte senescence related gene biosignatures in OA, and to analyze on the underlying ...
Nana Geng, Menglin Xian, Lin Deng, Biao Kuang, Yiming Pan, Kaiwen Liu, Yuanlan Ye, Mengtian Fan, Zhixun Bai, Fengjin Guo   +9 more
doaj   +3 more sources

FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma [PDF]

Cancer Genomics - Proteomics, 2020
Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations.Cytogenetic, RNA sequencing, and molecular analyses were performed.A FOS-ANKH transcript was found in the first tumor, whereas a FOS-RUNX2 was detected in the second ...
Panagopoulos, Ioannis, Gorunova, Ludmila, Lobmaier, Ingvild Victoria Koren, Andersen, Kristin, Kostolomov, Ilya, Lund-Iversen, Marius, Bjerkehagen, Bodil, Heim, Sverre   +7 more
openaire   +3 more sources

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]

, 2013
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit, A Romero, A Serrano, A Strasser, AA Genazzani, AJ Shaywitz, Andreas Breit, AS Kirshenbaum, B Fioravanti, B Knoll, B Zimmerman, BD Hudson, C Abbadie, C Gaudioso, CH Wang, DA Taylor, DB Wainscott, E Bullitt, E Grazzini, E Utreras, EJ Vallender, ES Burstein, F Jow, FA White, FA White, Franziska Petermann, G Buchwalter, G Kendall, GA Jamieson Jr, H Chen, H Jung, H Jung, H Subramanian, Hans Jürgen Solinski, HB McIlvain, HJ Solinski, Ingrid Boekhoff, J Li, JG Jackson, JH Sun, JJ Moore Jr, K Rothe, K Tatemoto, Kathrin Rothe, KL Pierce, L Hao, L Jenkins, LM Boland, M Brinkmann, N Eijkelkamp, N Katayama, N Kerr, OM Andrisani, P Kunapuli, P Sikand, PC Francel, PM Lembo, PS Puttfarcken, R Maldonado, RD Groth, RD Groth, RJ Davis, Roland Seifert, S Bhangoo, S Dolan, SF Fan, SK Bhangoo, SN Fatakia, SW Ko, Thomas Gudermann, V Baubet, VS Seybold, X Dong, Y Li   +73 more
core   +19 more sources

FOS Rescues Neuronal Differentiation of Sox2-Deleted Neural Stem Cells by Genome-Wide Regulation of Common SOX2 and AP1(FOS-JUN) Target Genes

Cells, 2021
The transcription factor SOX2 is important for brain development and for neural stem cells (NSC) maintenance. Sox2-deleted (Sox2-del) NSC from neonatal mouse brain are lost after few passages in culture.
Miriam Pagin, Mattias Pernebrink, Mattia Pitasi, Federica Malighetti, Chew-Yee Ngan, Sergio Ottolenghi, Giulio Pavesi, Claudio Cantù, Silvia K. Nicolis   +8 more
doaj   +1 more source

Identification of signature genes for renal ischemia‒reperfusion injury based on machine learning and WGCNA

Heliyon, 2023
Background: As an inevitable event after kidney transplantation, ischemia‒reperfusion injury (IRI) can lead to a decrease in kidney transplant success. The search for signature genes of renal ischemia‒reperfusion injury (RIRI) is helpful in improving the
Zechao Lu, Senkai Xu, Haiqin Liao, Yixin Zhang, Zeguang Lu, Zhibiao Li, Yushu Chen, Feng Guo, Fucai Tang, Zhaohui He   +9 more
doaj   +1 more source

Expression of CCL2, FOS, and JUN May Help to Distinguish Patients With IgA Nephropathy From Healthy Controls

Frontiers in Physiology, 2022
BackgroundIgA nephropathy (IgAN), the most common type of glomerulonephritis worldwide, can only be diagnosed mainly by renal biopsy owing to lack of effective biomarkers.
Xue Zhou, Xue Zhou, Xue Zhou, Ning Wang, Yuefeng Zhang, Pei Yu, Pei Yu   +6 more
doaj   +1 more source

The function of heterodimeric AP-1 comprised of c-Jun and c-Fos in activin mediated Spemann organizer gene expression. [PDF]

PLoS ONE, 2011
BACKGROUND:Activator protein-1 (AP-1) is a mediator of BMP or FGF signaling during Xenopus embryogenesis. However, specific role of AP-1 in activin signaling has not been elucidated during vertebrate development. METHODOLOGY/PRINCIPAL FINDINGS:We provide
Sung-Young Lee, Jaeho Yoon, Hyun-Shik Lee, Yoo-Seok Hwang, Sang-Wook Cha, Chul-Ho Jeong, Jong-Il Kim, Jae-Bong Park, Jae-Yong Lee, SungChan Kim, Mae Ja Park, Zigang Dong, Jaebong Kim   +12 more
doaj   +1 more source

Fos Facilitates Gallid Alpha-Herpesvirus 1 Infection by Transcriptional Control of Host Metabolic Genes and Viral Immediate Early Gene

Viruses, 2021
Gallid alpha-herpesvirus 1, also known as avian infectious laryngotracheitis virus (ILTV), continues to cause huge economic losses to the poultry industry worldwide.
Zhitao Wang, Yangyang Qiao, Zhijie Chen, Yumeng Liang, Lu Cui, Yanhui Zhang, Xuefeng Li, Li Xu, Ping Wei, Shengwang Liu, Hai Li   +10 more
doaj   +1 more source

Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat

Frontiers in Cellular and Infection Microbiology, 2023
Antimicrobial resistance is well-known to be a global health and development threat. Due to the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as fosfomycin (FOS), have been necessary.
Vittoria Mattioni Marchetti, Vittoria Mattioni Marchetti, Vittoria Mattioni Marchetti, Jaroslav Hrabak, Jaroslav Hrabak, Ibrahim Bitar, Ibrahim Bitar   +6 more
doaj   +1 more source