Results 231 to 240 of about 520,866 (339)

Glia Modulates Immune Responses in the Retina Through Distinct MHC Pathways. [PDF]

Glia
Intonti S, Kokona D, Zinkernagel MS, Enzmann V, Stein JV, Conedera FM.   +5 more
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

Exploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang, Maike Zheng, Yun Zhang, Yu Xue, Sibo Long, Chaohong Wang, Qing Sun, Jun Yan, Yiheng Shi, Bin Yang, Shang Ma, Tiantian Zhang, Lei Cao, Yan Chen, Wenfu Ju, Jing Zhang, Yan Zhao, Mengqiu Gao, Laurence Don Wai Luu, Xinting Yang, Guirong Wang   +20 more
wiley   +1 more source

Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells. [PDF]

BMC Mol Cell Biol
Nakazawa M, Nagao I, Ambrosini YM.
europepmc   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Dexamethasone-Induced MerTK^+/high M2c Macrophages Exhibit a Preference for Downregulated Gene Expression Profiles. [PDF]

J Genomics
Lee ZT, Salmanida FP, Chaung HC, Chang KT.   +3 more
europepmc   +1 more source

Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer. [PDF]

J Immunother Cancer
Tinoco JC, Saunders HI, Werner LR, Sun X, Chowanec EI, Heard A, Chalise P, Vahrenkamp JM, Wilson AE, Liu CX, Lei G, Wei J, Cros H, Mohammed H, Troester M, Perou C, Markiewicz MA, Gertz J, Balko JM, Hartman ZC, Hagan CR.   +20 more
europepmc   +1 more source

Tumor-microenvironment and molecular biology of classic Hodgkin lymphoma in children, adolescents, and young adults. [PDF]

Front Oncol
Aoki T, Wierzbicki K, Sun S, Steidl C, Giulino-Roth L.   +4 more
europepmc   +1 more source

Exploration of histone protein γ‐H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma

International Journal of Cancer, Volume 156, Issue 11, Page 2237-2250, 1 June 2025.
What's new? The remarkably poor prognosis of metastasized soft tissue sarcoma (STS) has motivated a search for novel biomarkers and therapeutic approaches. A promising candidate biomarker is H2A histone family member X (H2AX), a key player in DNA damage detection and repair pathways.
Adrian Georg Simon, Su Ir Lyu, Anne Maria Schultheis, David Stahl, Nora Wuerdemann, Sebastian Walter, Lena Hieggelke, Reinhard Buettner, Christiane Josephine Bruns, Peer Eysel, Lars Mortimer Schiffmann, Karl Knipper, Peter Mallmann, Alexander Quaas, Roland Ullrich   +14 more
wiley   +1 more source

Predicting reverse-bound peptide conformations in MHC Class II with PANDORA. [PDF]

Front Immunol
Rademaker DT, Parizi FM, van Vreeswijk M, Eerden S, Marzella DF, Xue LC.   +5 more
europepmc   +1 more source

Immunoglobulin‐like transcript 5 polarizes M2‐like tumor‐associated macrophages for immunosuppression in non‐small cell lung cancer

International Journal of Cancer, Volume 156, Issue 11, Page 2225-2236, 1 June 2025.
What's new? Despite advances, the efficacy of current immune checkpoint inhibitor therapies remains suboptimal in non‐small cell lung cancer due to the immunosuppressive tumor microenvironment. Here, ILT5 was found to be highly expressed in tumor‐associated macrophages from non‐small cell lung cancer tissues and associated with poor patient survival ...
Huijun Xu, Xuebing Fu, Shuyun Wang, Yihui Ge, Lu Zhang, Juan Li, Fang Zhang, Yang Yang, Yifu He, Yuping Sun, Aiqin Gao   +10 more
wiley   +1 more source