Results 31 to 40 of about 520,866 (339)
Toxins, 2012 Anthrax Lethal Toxin consists of Protective Antigen (PA) and Lethal Factor (LF), and current vaccination strategies focus on eliciting antibodies to PA. In human vaccination, the response to PA can vary greatly, and the response is often directed toward ...
Judith A. James +8 more
doaj +1 more source
The Major Histocompatibility Complex of Old World Camels—A Synopsis
Cells, 2019 This study brings new information on major histocompatibility complex (MHC) class III sub-region genes in Old World camels and integrates current knowledge of the MHC region into a comprehensive overview for Old World camels.
Martin Plasil +5 more
doaj +1 more source
The Structure of Human MHC Class II Genes
Autoimmunity, 1991 The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism.
Ann-Cathrin Svensson +4 more
openaire +3 more sources
Analysis and characterization of the major histocompatibility complex of domestic animals [PDF]
, 1990 The major histocompatibility complex (MHC) is a family of genes coding for molecules which play important roles in the immune response as well as many other cellular processes of a vertebrate organism.
Xu, Yuanxin
core +3 more sources
Frontiers in Immunology, 2021 Structures of peptide-loaded major histocompatibility complex class I (pMHC-I) and class II (pMHC-II) complexes are similar. However, whereas pMHC-II complexes include similar-sized IIα and IIβ chains, pMHC-I complexes include a heavy chain (HC) and a ...
Yanan Wu +4 more
doaj +1 more source
Selection and trans-species polymorphism of major histocompatibility complex class II genes in the order Crocodylia. [PDF]
PLoS ONE, 2014 Major Histocompatibility Complex (MHC) class II genes encode for molecules that aid in the presentation of antigens to helper T cells. MHC characterisation within and between major vertebrate taxa has shed light on the evolutionary mechanisms shaping the
Weerachai Jaratlerdsiri +4 more
doaj +1 more source
Biology, 2016 Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have ...
Unni Grimholt
doaj +1 more source
PML promotes MHC class II gene expression by stabilizing the class II transactivator [PDF]
Journal of Cell Biology, 2012 Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ–induced MHC class II expression.
Eberhard Schmitt +10 more
openaire +4 more sources
Two Mhc class I and two Mhc class II genes map to the chicken Rfp-Y system outside the B complex.
Proceedings of the National Academy of Sciences of the United States of America, 1994 Gene sequences highly similar to major histocompatibility complex (Mhc) class I and class II genes were recently recognized as mapping to a site in the genome of the chicken separate from the Mhc class I, class II, and B-G genes of the major ...
Marcia M. Miller +6 more
semanticscholar +1 more source
Giant panda genomic data provide insight into the birth-and-death process of mammalian major histocompatibility complex class II genes. [PDF]
PLoS ONE, 2009 To gain an understanding of the genomic structure and evolutionary history of the giant panda major histocompatibility complex (MHC) genes, we determined a 636,503-bp nucleotide sequence spanning the MHC class II region.
Qiu-Hong Wan +4 more
doaj +1 more source