Results 211 to 220 of about 5,499,505 (307)

Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties. The transcription factor Creb3l1 binds both gene promoters and drives their expression; its overexpression restores Col1a1 and Sparc levels and improves the gliding function, healing strength, and elastic modulus of ...
Qian Qian Yang, Zhanghao Huang, Yan Xue, Jia Yu Shi, You Lang Zhou   +4 more
wiley   +1 more source

A Systematic Review of the Role of Senescent Cells in Uterine Leiomyomas: Deciphering Molecular Pathways and Exploring Therapeutic Prospects. [PDF]

Reprod Sci
Howard S, Suresh A, Zerdan MB, Islam MS, Sayed SE, Michel R, Borahay M, Nagaraj S, Elisseeff J, Phillips J, Joseph E, Singh B, Segars JH.   +12 more
europepmc   +1 more source

Aging‐Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin‐Related Protein 1‐Associated Mitochondrial Vulnerability

Aging Cell, Volume 25, Issue 9, September 2026.
Chronic intermittent hypoxia (CIH) induces early myocardial remodeling and senescence‐associated injury without overt systolic failure in young mice. Aging‐related susceptibility, modeled in vivo by Tert−/− mice and in vitro by D‐gal‐treated primary cardiomyocytes, amplifies CIH‐associated cardiac dysfunction and cellular injury.
Yinghui Su, Yuyang Miao, Jin Tan, Feng Wang, Qiang Zhang   +4 more
wiley   +1 more source

METTL3 Regulates the Senescence of Stem Cells From the Apical Papilla by Mediating the m⁶A Modification of E2F3. [PDF]

Int Dent J
Sun C, Fang Y, Li Z, Li W.
europepmc   +1 more source

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Aging Cell, Volume 25, Issue 9, September 2026.
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong‐en Wang, Qianjin Guo, You Zhang, Jiawei Wu, Huiyun Xu   +10 more
wiley   +1 more source

Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues. [PDF]

Int J Mol Sci
Kim H, Kummerfeld E, Niedernhofer LJ, Aliferis C, Robbins PD, Wang J.   +5 more
europepmc   +1 more source

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

Aging Cell, Volume 25, Issue 9, September 2026.
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li, Zhen Yang, Wukaiyang Liang, Jie Huang, Tianyi Ji, Hao Nie, Zixin Wan, Yuqi Qiu, Yi Huang, Le Zhang, Cuntai Zhang, Jinhua Yan   +11 more
wiley   +1 more source

Reconstructing protein conformations to activate follicular enzyme-nutrient reservoirs for reversing follicle aging. [PDF]

Bioact Mater
Ling S, Liu M, Meng C, Huo K, Wang Y, Zhang Y, Wei Y, Zhou L, Du Y, Cui W.   +9 more
europepmc   +1 more source

SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin‐Modifying Complexes

Aging Cell, Volume 25, Issue 9, September 2026.
SIRT1 binds the LINE‐1 5′‐UTR and recruits the heterochromatin modifiers Lamin B1 and KAP1 to maintain H3K9me3 levels, thereby suppressing LINE‐1 retrotransposition. SIRT1 deficiency enhances LINE‐1 transcription, leading to upregulation of senescence‐associated secretory phenotype factors, activation of the cGAS‐STING pathway, and consequent cellular ...
Xiaona Wang, Tianbo Li, Huanyin Tang, Meng Xiao Liu, Qinghua Peng, Xiao Huang, Zhiyong Mao, Ying Jiang, Anke Geng   +8 more
wiley   +1 more source

Decoding Cervical Neuroendocrine Carcinoma: A Practical Review of Diagnostic Pitfalls, Differential Diagnosis and Molecular Insights. [PDF]

Diagnostics (Basel)
Onofrei Popa A, Gurau G, Patrichi G, Gurau AM, Mehedinti RC, Satala CB.   +5 more
europepmc   +1 more source