Results 221 to 230 of about 5,499,505 (307)

Timing‐Dependent Clearance of p16‐Positive Cells Mitigates Radiation‐Induced Accelerated Aging

Aging Cell, Volume 25, Issue 9, September 2026.
Genotoxic stress induces a progressive accelerated aging‐like phenotype driven by the delayed accumulation of p16Ink4a‐positive senescent cells. Selective clearance of these cells improves healthspan, tissue function, and survival only when initiated after senescent cells have accumulated, highlighting a critical therapeutic window for senescence ...
Karla Valdivieso, Melanie Weigand, Daniela G. Costa, Gung Lee, Nick Pirius, Helene Martini, Shivangi Oberai, Christina Inman, Yi Zhu, Thomas von Zglinicki, Sundeep Khosla, Nathan LeBrasseur, João F. Passos, Tamara Tchkonia, James L. Kirkland, Diana Jurk   +15 more
wiley   +1 more source

Clinicopathological and molecular characterization of HPV-associated cervical poorly cohesive carcinoma: a rare aggressive entity. [PDF]

J Pathol Clin Res
Liu W, Wang XJ, Cui YM, Liu JC, Zhang J, Zhang LB, Lei X, Weng X, Shen W, Miao WX, Ye JC, He TM, Xu Q, Shi Y, Hu D.   +14 more
europepmc   +1 more source

Parents' experiences of diagnosis and specialist care of children's rare birthmarks

British Journal of Health Psychology, Volume 31, Issue 3, September 2026.
Abstract Objectives Congenital melanocytic naevi (CMN) and arteriovenous malformations (AVM) are rare, severe and incurable birthmark conditions associated with lifelong visible difference and complex medical needs. Despite the importance of early health care experiences for parental and child adjustment in general, these remain unexplored in this ...
Morgan B. Zolkwer, Satyamaanasa Polubothu, Veronica A. Kinsler, Amy Slater, Ella Guest   +4 more
wiley   +1 more source

Exercise rejuvenates bone marrow mesenchymal stem cells associated with the inhibition of inflammatory factors and senescence-related factors. [PDF]

Biochem Biophys Rep
Dong XJ, Zhao Q, Zhang WM, Liu JG, Zhang XD, Yi R.   +5 more
europepmc   +1 more source

Upregulation of CSN8 induces a unique senescence-like state with robust tumor-promoting properties in epithelial ovarian cancer cells under hypoxia. [PDF]

J Transl Med
Ruan M, Xi X, Guo N, Wang F, Ma R, Ju S, Lv J, Hou S, Ju S.   +8 more
europepmc   +1 more source

Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk

International Endodontic Journal, Volume 59, Issue 9, Page 1743-1759, September 2026.
ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar, M. Huang, M. M. Abdalla, P. Neelakantan, C. K. Y. Yiu   +4 more
wiley   +1 more source

PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways. [PDF]

EBioMedicine
Gu W, Wan R, Chen Z, Wang W, Xie S, Hao C, Liu G, Wan M, Gao P.   +8 more
europepmc   +1 more source

Senescent Human Liver Endothelial Cells Mediate CD4+ T Cell Recruitment via ICOSL

Immunology, Volume 179, Issue 1, Page 149-160, September 2026.
In this study, we detect senescent endothelial cells within chronically diseased human liver tissues. Next, we develop a novel protocol for the induction of paracrine senescence in primary human liver endothelial cells and explore their functionality.
Daniel A. Patten, Amy Lumley, Alex L. Wilkinson, Ayla O’Keeffe, Kelvin Yin, Niranjan Shirgaonkar, Ran Gao, Ramanuj DasGupta, Matthew Hoare, Shishir Shetty   +9 more
wiley   +1 more source

Phenotypic alterations and PI3K-AKT pathway regulation in senescence of human tonsil mesenchymal stem cells. [PDF]

Stem Cell Res Ther
Qiu X, Lin Z, Sun Y, Zhao A, Chen X.
europepmc   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source