Results 71 to 80 of about 252,546 (355)

Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer's patients.

PLoS ONE, 2019
The dementia epidemic is likely to expand worldwide as the aging population continues to grow. A better understanding of the molecular mechanisms that lead to dementia is expected to reveal potentially modifiable risk factors that could contribute to the
Judith A Potashkin, Virginie Bottero, Jose A Santiago, James P Quinn   +3 more
doaj   +1 more source

Globin gene switching — a paradigm or what?

Current Biology, 1991
The delineation of the beta-globin locus control region has led to a new understanding of the developmental regulation of the beta-globin gene cluster. It now seems that globin gene switching is effected through the sequential and mutually exclusive interaction of the locus control region with the embryonic, fetal and adult stage specific globin genes.
Enver, T, Greaves, D
openaire   +2 more sources

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana

, 2013
Schmal C, Reimann P, Staiger D. A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana. PLoS Computational Biology. 2013;9(3): e1002986.The circadian clock controls many physiological processes in higher
Staiger Dorothee, Peter Reimann, Reimann, Peter, Schmal, Christoph, Dorothee Staiger (40787), Christoph Schmal, Schmal Christoph, Reimann Peter, Peter Reimann (395937), Staiger, Dorothee, Dorothee Staiger, Christoph Schmal (395936)   +11 more
core   +1 more source

Optimizing the Bioprocesses of Bacteriocin Production in Lacticaseibacillus paracasei HD1.7 by the “Acetate Switch”: Novel Insights into the Labor Division Between Energy Metabolism, Quorum Sensing, and Acetate

Foods
Acetate may act as a signaling molecule, regulating Paracin 1.7 production via quorum sensing (QS) in Lacticaseibacillus paracasei HD1.7. The “acetate switch” phenomenon requires mechanistic exploration to optimize Paracin 1.7 production.
Weige Yao, Rui Sun, Wen Zhang, Jie Kang, Zhenchao Wu, Liangyang Mao, Ying Yang, Shuo Li, Gang Song, Jingping Ge, Wenxiang Ping   +10 more
doaj   +1 more source

Molecular Light Switches for Plant Genes [PDF]

The Plant Cell, 1990
Light is essential for normal plant growth and development not only as a source of energy but also as a stimulus that regulates numerous developmental and metabolic proc? esses. The plant's responses are varied and complex and dependent upon the quality and quantity of ambient light.
Gilmartin, P.M., Sarokin, L., Memelink, J., Chua, N.-H.   +3 more
openaire   +2 more sources

CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression.

Cell, 1996
While changes in gene expression are critical for many brain functions, including long-term memory, little is known about the cellular processes that mediate stimulus-transcription coupling at central synapses. In studying the signaling pathways by which
H. Bito, K. Deisseroth, R. Tsien
semanticscholar   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Deciphering c-MYC-regulated genes in two distinct tissues [PDF]

, 2011
Background: The transcription factor MYC is a critical regulator of diverse cellular processes, including both replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes in vivo remain obscure.
Lesley Ward, Heather Turner, Michael Khan, Ward, Lesley (Lesley A.), Brown, Helen, Turner, Heather, Helen Brown, Hunter, Ewan, Ward, Lesley, Khan, Michael, Samuel C Robson, Stella Pelengaris, Brown, Helen (Helen E.), Robson, Samuel C, Robson, Samuel Charles, Pelengaris, Stella, Ewan Hunter   +16 more
core   +1 more source

A long-term epigenetic memory switch controls bacterial virulence bimodality

eLife, 2017
When pathogens enter the host, sensing of environmental cues activates the expression of virulence genes. Opposite transition of pathogens from activating to non-activating conditions is poorly understood.
Irine Ronin, Naama Katsowich, Ilan Rosenshine, Nathalie Q Balaban   +3 more
doaj   +1 more source