Results 51 to 60 of about 252,546 (355)

A complex genetic switch involving overlapping divergent promoters and DNA looping regulates expression of conjugation genes of a gram-positive plasmid. [PDF]

PLoS Genetics, 2014
Plasmid conjugation plays a significant role in the dissemination of antibiotic resistance and pathogenicity determinants. Understanding how conjugation is regulated is important to gain insights into these features.
Gayetri Ramachandran, Praveen K Singh, Juan Roman Luque-Ortega, Luis Yuste, Carlos Alfonso, Fernando Rojo, Ling J Wu, Wilfried J J Meijer   +7 more
doaj   +1 more source

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

Cell Stem Cell, 2015
SUMMARY Stem cells undergo a shift in metabolic substrate utilization during specification and/or differentiation, a process that has been termed metabolic reprogramming.
James G. Ryall, Stefania Dell’Orso, A. Derfoul, Aster H. Juan, H. Zare, Xuesong Feng, D. Clermont, Miroslav Koulnis, G. Gutierrez-Cruz, M. Fulco, V. Sartorelli   +10 more
semanticscholar   +1 more source

Switch-like genes populate cell communication pathways and are enriched for extracellular proteins-0

, 2011
Copyright information:Taken from "Switch-like genes populate cell communication pathways and are enriched for extracellular proteins"http://www.biomedcentral.com/1471-2164/9/3BMC Genomics 2008;9():3-3.Published online 4 Jan 2008PMCID:PMC2257939..
Aydin Tozeren (84457), Adam Ertel (84455)   +1 more
core   +1 more source

IgH 3' regulatory region increases ectopic class switch recombination.

PLoS Genetics, 2021
DNA lesions inflicted by activation-induced deaminase (AID) instrumentally initiate the processes reshaping immunoglobulin genes in mature B-cells, from local somatic hypermutation (SHM) to junctions of distant breaks during class switch recombination ...
Sandrine Le Noir, Amélie Bonaud, Bastien Hervé, Audrey Baylet, François Boyer, Sandrine Lecardeur, Zeliha Oruc, Christophe Sirac, Michel Cogné   +8 more
doaj   +1 more source

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells

, 2005
Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID).
Lennart Hammarström, Hammarström, L,, Lahdesmaki, A, Aleksi Lähdesmäki, Wei Zhou, Andrew R. Gennery, Jones, AM, Michael R. Ehrenstein, Pan-Hammarstrom, Q, Hammarstrom, L, Zhou, W, Gennery, AR, Ehrenstein, MR, Anne-Marie Jones, Richard A. Gatti, Gatti, RA, Qiang Pan-Hammarström   +16 more
core   +1 more source

Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility.

PLoS Computational Biology, 2009
Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. However, prior to lineage commitment, genes are primed at low expression levels.
Vijay Chickarmane, Tariq Enver, Carsten Peterson   +2 more
doaj   +1 more source

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

Nucleic Acids Research, 2010
Polycomb group (PcG) proteins are transcriptional repressors, which regulate proliferation and cell fate decisions during development, and their deregulated expression is a frequent event in human tumours.
Diego Pasini, M. Malatesta, H. Jung, J. Walfridsson, Anton Willer, L. Olsson, Julie Skotte, A. Wutz, B. Porse, O. Jensen, K. Helin   +10 more
semanticscholar   +1 more source

Switch-like genes populate cell communication pathways and are enriched for extracellular proteins-2

, 2011
Copyright information:Taken from "Switch-like genes populate cell communication pathways and are enriched for extracellular proteins"http://www.biomedcentral.com/1471-2164/9/3BMC Genomics 2008;9():3-3.Published online 4 Jan 2008PMCID:PMC2257939. shown in
Aydin Tozeren (84457), Adam Ertel (84455)   +1 more
core   +1 more source

H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation. [PDF]

, 2013
SummaryChromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear.
Northrup, D., Levens, D., Tang, Q., Liu, Chengyu, Zhao, Keji, Hu, G., Cui, K., Wang, Chaochen, Hu, Gangqing, Crane-Robinson, Colyn, Ge, Kai, Northrup, Daniel, Wang, C., Tang, Qingsong, Zhao, K., Levens, David, Liu, C., Cui, Kairong, Ge, K.   +18 more
core   +1 more source

A Green Light to Switch on Genes: Revisiting Trithorax on Plants

Plants, 2022
The Trithorax Group (TrxG) is a highly conserved multiprotein activation complex, initially defined by its antagonistic activity with the PcG repressor complex.
Diego Ornelas-Ayala, Carlos Cortés-Quiñones, José Olvera-Herrera, Berenice García-Ponce, Adriana Garay-Arroyo, Elena R. Álvarez-Buylla, Maria de la Paz Sanchez   +6 more
doaj   +1 more source