The effect of heat stress on frame switch splicing of X-box binding protein 1 gene in horse [PDF]
Asian-Australasian Journal of Animal Sciences, 2019 Objective Among stress responses, the unfolded protein response (UPR) is a well-known mechanism related to endoplasmic reticulum (ER) stress. ER stress is induced by a variety of external and environmental factors such as starvation, ischemia, hypoxia ...
Hyo Gun Lee +11 more
doaj +1 more source
Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle
Cell Reports, 2018 SUMMARY The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment. While food is a known zeitgeber for clocks in peripheral tissues, it remains unclear how lack of food influences ...
Kenichiro Kinouchi +10 more
semanticscholar +1 more source
A molecular switch created by in vitro recombination of nonhomologous genes.
Chemistry and Biology, 2004 We have created a molecular switch by the in vitro recombination of nonhomologous genes and subjecting the recombined genes to evolutionary pressure. The gene encoding TEM1 β-lactamase was circularly permuted in a random fashion and subsequently randomly
Gurkan Guntas +2 more
semanticscholar +4 more sources
Switching genes on and off in haemopoiesis
Biochemical Society Transactions, 2008 At present, the molecular mechanisms by which stem cells commit to and differentiate towards specific lineages are poorly characterized, and will need to be better understood before stem cells can be exploited fully in experimental and clinical settings.
Garrick, D +3 more
openaire +3 more sources
In silico recognition of a prognostic signature in basal-like breast cancer patients.
PLoS ONE, 2022 BackgroundTriple-negative breast cancers (TNBCs) display poor prognosis, have a high risk of tumour recurrence, and exhibit high resistance to drug treatments.
Federica Conte +5 more
doaj +2 more sources
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.
Genes & Development, 2002 Rho GTPases control many aspects of cell behavior through the regulation of multiple signal transduction pathways (Van Aelst and D’Souza-Schorey 1997; Hall 1998).
A. Schmidt, A. Hall
semanticscholar +1 more source
Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]
, 2010 Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Maria E Merlo +43 more
core +1 more source
Regulation of Human Globin Gene Switching [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 1993 Abstract This paper describes the mechanism of regulation of the human β-globin on the basis of a number of natural mutations and experiments in transgenic mice. From these data we conclude that this multigene locus is regulated at a number of different levels involving specific interactions between the Locus Control Region (LCR) and ...
F. Grosveld +13 more
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MTL-independent phenotypic switching in Candida tropicalis and a dual role for Wor1 in regulating switching and filamentation. [PDF]
PLoS Genetics, 2013 Phenotypic switching allows for rapid transitions between alternative cell states and is important in pathogenic fungi for colonization and infection of different host niches.
Allison M Porman +4 more
doaj +1 more source
MYC is a metastasis gene for non-small-cell lung cancer. [PDF]
, 2009 Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis.
Christian Korn +26 more
core +1 more source