Results 31 to 40 of about 252,546 (355)
Scientific Reports, 2021 Non-functioning pituitary adenomas (NFPAs) are typical pituitary macroadenomas in adults associated with increased mortality and morbidity. Although pituitary adenomas are commonly considered slow-growing benign brain tumors, numerous of them possess an ...
Nasibeh Khayer +4 more
doaj +1 more source
Stochastic gene expression in switching environments [PDF]
Journal of Mathematical Biology, 2007 We study a stochastic model proposed recently in the genetic literature to explain the heterogeneity of cell populations or of gene products. Cells are located in two colonies, whose sizes fluctuate as birth and migration processes in switching environments.
Gander, Martin Jakob +2 more
openaire +7 more sources
Frontiers in Marine Science, 2020 The insulin-like androgenic gland hormone (IAG) secreted from the androgenic gland (AG) is a unique endocrine controller (the IAG-switch) of crustacean sexual differentiation.
Tom Levy +8 more
doaj +1 more source
Alzheimer’s disease: insights from a network medicine perspective
Scientific Reports, 2022 Alzheimer’s disease (AD) is the most common neurodegenerative disease that currently lacks available effective therapy. Thus, identifying novel molecular biomarkers for diagnosis and treatment of AD is urgently demanded. In this study, we exploited tools
Federica Conte, Paola Paci
doaj +1 more source
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
Nature Communications, 2019 Cells maintain the balance between homeostasis and inflammation by adapting and integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway. Our understanding of how a tailored switch from homeostasis to a strong receptor-
Ekaterini Platanitis +9 more
semanticscholar +1 more source
Transcriptional dynamics of the embryonic stem cell switch.
PLoS Computational Biology, 2006 Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture of the transcriptional regulatory circuitry responsible for cell determination, which involves the transcription factors OCT4, SOX2, and NANOG.
Vijay Chickarmane +4 more
doaj +1 more source
The Plant Cell, 2014 A small pool of putative switch genes, whose expression is negatively correlated with that of genes outside their community in the network, appear to mark the shift from immature to mature growth.
M. C. Palumbo +7 more
semanticscholar +1 more source
PLoS Genetics, 2014 Seed germination and subsequent seedling growth define crucial steps for entry into the plant life cycle. For those events to take place properly, seed developmental genes need to be silenced whereas vegetative growth genes are activated.
Anne Molitor +3 more
semanticscholar +1 more source
eLife, 2017 High-resolution daylight vision is mediated by cone photoreceptors. The molecular program responsible for the formation of their light sensor, the outer segment, is not well understood. We correlated daily changes in ultrastructure and gene expression in
Janine M Daum +6 more
doaj +1 more source
A temporal switch model for estimating transcriptional activity in gene expression [PDF]
, 2013 Motivation: The analysis and mechanistic modelling of time series gene expression data provided by techniques such as microarrays, NanoString, reverse transcription–polymerase chain reaction and advanced sequencing are invaluable for developing an ...
Jenkins, Dafyd J. +2 more
core +1 more source