Switch-like genes populate cell communication pathways and are enriched for extracellular proteins
BMC Genomics, 2008 Background Recent studies have placed gene expression in the context of distribution profiles including housekeeping, graded, and bimodal (switch-like).
Tozeren Aydin, Ertel Adam
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The dynamic architecture of the metabolic switch in
BMC Genomics, 2010 Background During the lifetime of a fermenter culture, the soil bacterium S. coelicolor undergoes a major metabolic switch from exponential growth to antibiotic production. We have studied gene expression patterns during this switch, using a specifically
Bonin Michael +34 more
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A genetic switch controls the production of flagella and toxins in Clostridium difficile.
PLoS Genetics, 2017 In the human intestinal pathogen Clostridium difficile, flagella promote adherence to intestinal epithelial cells. Flagellar gene expression also indirectly impacts production of the glucosylating toxins, which are essential to diarrheal disease ...
Brandon R Anjuwon-Foster, Rita Tamayo
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Expression profiles of switch-like genes accurately classify tissue and infectious disease phenotypes in model-based classification [PDF]
BMC Bioinformatics, 2008 Background Large-scale compilation of gene expression microarray datasets across diverse biological phenotypes provided a means of gathering a priori knowledge in the form of identification and annotation of bimodal genes in the human and mouse genomes ...
Tozeren Aydin, Gormley Michael
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Switch-like gene expression modulates disease risk
Nature CommunicationsWhile switch-like gene expression (“on” in some individuals and “off” in others) has been linked to biological variation and disease susceptibility, a systematic analysis across tissues is lacking. Here, we analyze genomes, transcriptomes, and methylomes
Alber Aqil +8 more
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Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality [PDF]
BMC Genomics, 2008 Background Gene expression is controlled over a wide range at the transcript level through complex interplay between DNA and regulatory proteins, resulting in profiles of gene expression that can be represented as normal, graded, and bimodal (switch-like)
Tozeren Aydin, Ertel Adam
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Key Disease Mechanisms Linked to Amyotrophic Lateral Sclerosis in Spinal Cord Motor Neurons
Frontiers in Molecular Neuroscience, 2022 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no modifying treatments available. The molecular mechanisms underpinning disease pathogenesis are not fully understood.
Virginie Bottero +3 more
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Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombination. [PDF]
PLoS ONE, 2013 The immunoglobulin heavy (H) chain class switch is mediated by a deletional recombination event between µ and γ, α, or ε constant region genes. This recombination event is upregulated during immune responses by a regulatory region that lies 3' of the ...
Wesley A Dunnick +3 more
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npj Systems Biology and Applications, 2021 In this study, we integrate the outcomes of co-expression network analysis with the human interactome network to predict novel putative disease genes and modules. We first apply the SWItch Miner (SWIM) methodology, which predicts important (switch) genes
Paola Paci +5 more
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Sex-specific transcriptional rewiring in the brain of Alzheimer’s disease patients
Frontiers in Aging Neuroscience, 2022 Sex-specific differences may contribute to Alzheimer’s disease (AD) development. AD is more prevalent in women worldwide, and female sex has been suggested as a disease risk factor. Nevertheless, the molecular mechanisms underlying sex-biased differences
Jose A. Santiago +2 more
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