Results 1 to 10 of about 252,546 (355)

Alternative Isoform Regulation in Human Tissue Transcriptomes

Nature, 2008
Through alternative processing of pre-messenger RNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions.
Eric T. Wang, R. Sandberg, Shujun J Luo, I. Khrebtukova, Lu Zhang, C. Mayr, S. Kingsmore, G. Schroth, C. Burge   +8 more
semanticscholar   +1 more source

Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation

BMC Genomics, 2012
Background The fetal and adult globin genes in the human β-globin cluster on chromosome 11 are sequentially expressed to achieve normal hemoglobin switching during human development.
Li Biaoru, Ding Lianghao, Li Wei, Story Michael D, Pace Betty S   +4 more
doaj   +1 more source

Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation

npj Systems Biology and Applications
Cancer cell populations, such as chronic lymphocytic leukemia (CLL), are characterized by aberrant proliferation and plasticity: cells may switch between states so increasing population heterogeneity.
Olga Sirbu, Gunjan Agarwal, Alessandro Giuliani, Kumar Selvarajoo   +3 more
doaj   +1 more source

miR156-regulated SPL transcription factors define an endogenous flowering pathway in Arabidopsis thaliana.

Cell, 2009
The FT gene integrates several external and endogenous cues controlling flowering, including information on day length. A complex of the mobile FT protein and the bZIP transcription factor FD in turn has a central role in activating genes that execute ...
Jiawei Wang, Benjamin Czech, D. Weigel
semanticscholar   +1 more source

Obesity induces a phenotypic switch in adipose tissue macrophage polarization.

Journal of Clinical Investigation, 2007
C. Lumeng, Jennifer L Bodzin, A. Saltiel
semanticscholar   +1 more source

Genetically stable kill-switch using “demon and angel” expression construct of essential genes

Frontiers in Bioengineering and Biotechnology
Genetic instability of synthetic genetic devices is a key obstacle for practical use. This problem is particularly critical in kill-switches for conditional host killing.
Yusuke Kato, Hirotada Mori
doaj   +1 more source

S100a9 might act as a modulator of the Toll-like receptor 4 transduction pathway in chronic rhinosinusitis with nasal polyps

Scientific Reports
Chronic rhinosinusitis with nasal polyp (CRSwNP) is a highly prevalent disorder characterized by persistent nasal and sinus mucosa inflammation. Despite significant morbidity and decreased quality of life, there are limited effective treatment options ...
Nasibeh Khayer, Maryam Jalessi, Mohammad Farhadi, Zahra Azad   +3 more
doaj   +1 more source

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

Planta Medica, 2008
Y. Surh, J. Kundu, H. Na
semanticscholar   +1 more source

Globin Gene Switching [PDF]

Journal of Biological Chemistry, 1996
Tohru Ikuta, Thalia Papayannopoulou, George Stamatoyannopoulos, Yuet Wai Kan   +3 more
openaire   +1 more source

Mechanism and regulation of class switch recombination.

Annual Review of Immunology, 2008
J. Stavnezer, J. Guikema, C. E. Schrader
semanticscholar   +1 more source