Results 21 to 30 of about 252,546 (355)
Switching on the Lights for Gene Therapy [PDF]
PLoS ONE, 2007 Strategies for non-invasive and quantitative imaging of gene expression in vivo have been developed over the past decade. Non-invasive assessment of the dynamics of gene regulation is of interest for the detection of endogenous disease-specific biological alterations (e.g., signal transduction) and for monitoring the induction and regulation of ...
Winkeler, A +17 more
openaire +6 more sources
Stochastic Epigenetic Dynamics of Gene Switching [PDF]
Physical Review E, 2020 Abstract Epigenetic modifications of histones crucially affect the eukaryotic gene activity. We theoretically analyze the dynamical effects of histone modifications on gene switching by using the Doi-Peliti operator formalism of chemical reaction kinetics.
Bhaswati Bhattacharyya +2 more
openaire +4 more sources
Regulating tumor suppressor genes: post-translational modifications
Signal Transduction and Targeted Therapy, 2020 Tumor suppressor genes cooperate with each other in tumors. Three important tumor suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted on chromosome ten (PTEN) are functionally associated and they regulated by post ...
Ling Chen, Shuang Liu, Y. Tao
semanticscholar +1 more source
Epigenetic control of virulence gene expression in Pseudomonas aeruginosa by a LysR-type transcription regulator. [PDF]
PLoS Genetics, 2009 Phenotypic variation within an isogenic bacterial population is thought to ensure the survival of a subset of cells in adverse conditions. The opportunistic pathogen Pseudomonas aeruginosa variably expresses several phenotypes, including antibiotic ...
Keith H Turner +2 more
doaj +1 more source
Classification of genes and putative biomarker identification using distribution metrics on expression profiles. [PDF]
PLoS ONE, 2010 BACKGROUND: Identification of genes with switch-like properties will facilitate discovery of regulatory mechanisms that underlie these properties, and will provide knowledge for the appropriate application of Boolean networks in gene regulatory models ...
Hung-Chung Huang +2 more
doaj +1 more source
Nature Reviews Molecular Cell Biology, 2018 The chromatin remodelling complex NuRD fine-tunes gene expression by modulating nucleosome density at gene regulatory elements.
openaire +2 more sources
Fine-tuning the expression of target genes using a DDI2 promoter gene switch in budding yeast
Scientific Reports, 2019 Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application.
Yong Wang +6 more
semanticscholar +1 more source
Cell Metabolism, 2006 Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia through increased conversion of glucose to pyruvate and subsequently to lactate.
Jung-whan Kim +3 more
semanticscholar +1 more source
Basal-like specific switch genes.
, 2022 The table is composed of two separated sheets. The first sheet reports the complete list of 108 switch genes found to be specific for basal-like breast cancer subtype.
Marco Salvatore (470253) +5 more
core +1 more source
BMC Bioinformatics, 2018 Background It is well-known that glioblastoma contains self-renewing, stem-like subpopulation with the ability to sustain tumor growth. These cells – called cancer stem-like cells – share certain phenotypic characteristics with untransformed stem cells ...
Giulia Fiscon +2 more
doaj +1 more source