Results 61 to 70 of about 252,546 (355)
Noise Minimisation in Gene Expression Switches
PLoS ONE, 2013 Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes.
Diana Monteoliva +2 more
openaire +6 more sources
Gene Switching and the Stability of Odorant Receptor Gene Choice [PDF]
Cell, 2004 Individual olfactory sensory neurons express only a single odorant receptor from a large family of genes, and this singularity is an essential feature in models of olfactory perception. We have devised a genetic strategy to examine the stability of receptor choice. We observe that immature olfactory sensory neurons that express a given odorant receptor
Shykind, Benjamin M +7 more
openaire +2 more sources
A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus
Genes & Development, 2016 During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster.
Leonardo Beccari +9 more
semanticscholar +1 more source
A catalogue of validated single nucleotide polymorphisms in bovine orthologs of mammalian imprinted genes and associations with beef production traits [PDF]
, 2010 peer-reviewedGenetic (or ‘genomic’) imprinting, a feature of approximately 100 mammalian genes, results in monoallelic expression from one of the two parentally inherited chromosomes. To date, most studies have been directed on imprinted genes in murine
Magee, David A +23 more
core +1 more source
The identification of switch-like alternative splicing exons among multiple samples with RNA-Seq data. [PDF]
PLoS ONE, 2017 Alternative splicing is an ubiquitous phenomenon in most human genes and has important functions. The switch-like exon is the type of exon that has a high level of usage in some tissues, but has a low level of usage in the other tissues.
Zhiyi Qin, Xuegong Zhang
doaj +1 more source
Dichotomous noise models of gene switches [PDF]
The Journal of Chemical Physics, 2015 Molecular noise in gene regulatory networks has two intrinsic components, one part being due to fluctuations caused by the birth and death of protein or mRNA molecules which are often present in small numbers and the other part arising from gene state switching, a single molecule event.
Davit. A. Potoyan, Peter. G. Wolynes
openaire +4 more sources
PLoS Genetics, 2011 Behavioral plasticity is the most striking trait in locust phase transition. However, the genetic basis for behavioral plasticity in locusts is largely unknown.
Wei Guo +6 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu +8 more
wiley +1 more source
The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
OncoTarget, 2011 The Hedgehog (HH) signaling pathway leads to activation of GLI, which transcriptionally regulate target genes. Regulated HH signaling activity is critical during embryogenesis while aberrantly activated HH signaling is evident in a variety of human ...
Tapati Mazumdar +4 more
semanticscholar +1 more source
Switch-like genes populate cell communication pathways and are enriched for extracellular proteins-1
, 2011 Copyright information:Taken from "Switch-like genes populate cell communication pathways and are enriched for extracellular proteins"http://www.biomedcentral.com/1471-2164/9/3BMC Genomics 2008;9():3-3.Published online 4 Jan 2008PMCID:PMC2257939. shown in
Aydin Tozeren (84457) +1 more
core +1 more source