Results 11 to 20 of about 1,028,351 (305)

Coexistence of virome-encoded health-associated genes and pathogenic genes in global habitats [PDF]

Applied and Environmental Microbiology
Viral remnants constitute approximately 8% of the human genome, reflecting extensive historical gene exchange between viruses and their hosts. Some viral genomes harbor genes acquired through horizontal gene transfer that are associated with potential ...
Min Qian, Dong Zhu, Ke-yu Yao, Shu-yue Liu, Meng-ke Li, Mao Ye, Yong-guan Zhu   +6 more
doaj   +2 more sources

Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family

Viruses, 2020
The genesis of gene families by the capture of host genes and their subsequent duplication is a crucial process in the evolution of large DNA viruses. CD48 is a cell surface molecule that interacts via its N-terminal immunoglobulin (Ig) domain with the ...
Pablo Martínez-Vicente, Domènec Farré, Pablo Engel, Ana Angulo   +3 more
doaj   +1 more source

Associations between single nucleotide polymorphisms in cellular viral receptors and attachment factor-related genes and humoral immunity to rubella vaccination. [PDF]

PLoS ONE, 2014
Viral attachment and cell entry host factors are important for viral replication, pathogenesis, and the generation and sustenance of immune responses after infection and/or vaccination, and are plausible genetic regulators of vaccine-induced immunity ...
Iana H Haralambieva, Nathaniel D Lambert, Inna G Ovsyannikova, Richard B Kennedy, Beth R Larrabee, V Shane Pankratz, Gregory A Poland   +6 more
doaj   +1 more source

Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex. [PDF]

, 2017
Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens.
Behura, Susanta K, Gershwin, Laurel J, Grupioni, Natalia V, Kim, JaeWoo, Neibergs, Holly L, Regitano, Luciana CA, Schnabel, Robert D, Seabury, Christopher M, Taylor, Jeremy F, Tizioto, Polyana C, Toaff-Rosenstein, Rachel, Van Eenennaam, Alison L   +11 more
core   +3 more sources

RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus [PDF]

, 2011
Epstein-Barr virus (EBV) immortalizes resting B-cells and is a key etiologic agent in the development of numerous cancers. The essential EBV-encoded protein EBNA 2 activates the viral C promoter (Cp) producing a message of ~120 kb that is differentially ...
A Bakos, A Bell, A Dey, A Lin, AI Bell, B Kempkes, B Sugden, BM Peterlin, C Lee, CD Gregory, CF Bourgeois, CH Wu, CH Wu, D Ivanov, DA Gilchrist, DC Hargreaves, DS Gilmour, DS Gilmour, DY Wu, DY Wu, E Johannsen, E Klein, EA Abbate, G Kelly, G Laux, H Gross, H Kirby, Helen M. Webb, I Tempera, J You, JH Yik, JI Cohen, K Fujinaga, KD Robertson, KD Robertson, L Waltzer, L Wang, M Ottinger, M Woisetschlaeger, M Woisetschlaeger, Michelle J. West, MJ West, MK Jang, N Alazard, N Kaplan, NA Brown, NF Marshall, NP Gomes, P Filippakopoulos, Paul M. Lieberman, R Tierney, Richard D. Palermo, S Egloff, S Egloff, S Swaminathan, SH Chao, SJ Bark-Jones, SR Grossman, SY Wu, T Fujita, T Fujita, T Henkel, T Wada, T Wada, U Zimber-Strobl, VT Nguyen, W Lucchesi, W Yue, W Yue, W Yue, W Zhu, X Tong, X Tong, X Tong, YK Kim, Z Yang   +75 more
core   +7 more sources

Interferon-induced genes of the expanded IFIT family show conserved antiviral activities in non-mammalian species. [PDF]

PLoS ONE, 2014
Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in the protective response to viral infection, although the precise mechanism of IFITs for reducing viral proliferation is currently unknown.
Mónica Varela, Patricia Diaz-Rosales, Patricia Pereiro, Gabriel Forn-Cuní, Maria M Costa, Sonia Dios, Alejandro Romero, Antonio Figueras, Beatriz Novoa   +8 more
doaj   +1 more source

Reads Binning Improves the Assembly of Viral Genome Sequences From Metagenomic Samples

Frontiers in Microbiology, 2021
Metagenomes can be considered as mixtures of viral, bacterial, and other eukaryotic DNA sequences. Mining viral sequences from metagenomes could shed insight into virus–host relationships and expand viral databases.
Kai Song
doaj   +1 more source

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. [PDF]

, 2020
Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo.
Chang, Deching, Chang, Hao-Fang, Chen, Bing-Mao, Chen, Shih-Han, Chen, Thomas C, Collins, Sara, Kasahara, Noriyuki, Lin, Sheng-Che, Lu, Yin-Che, Sun, Jui-Ming, Tai, Chien-Kuo, Wang, Hsin-Ell, Wang, Weijun, Wu, Shu-Fen   +13 more
core   +2 more sources

Viral Vector-Based Gene Therapy

International Journal of Molecular Sciences, 2023
Gene therapy is a technique involving the modification of an individual’s genes for treating a particular disease. The key to effective gene therapy is an efficient carrier delivery system. Viral vectors that have been artificially modified to lose their pathogenicity are used widely as a delivery system, with the key advantages of their natural high ...
Xuedan Li, Yang Le, Zhegang Zhang, Xuanxuan Nian, Bo Liu, Xiaoming Yang   +5 more
openaire   +2 more sources

Identification of the Immediate-Early Genes of Cyprinid Herpesvirus 2

Viruses, 2020
Cyprinid herpesvirus 2 (CyHV-2), which infects goldfish and crucian carp causing high mortality, is an emerging viral pathogen worldwide. The genome of CyHV-2 is large and comprises double-stranded DNA, including several genes similar to cyprinid ...
Ruizhe Tang, Liqun Lu, Beiyang Wang, Jiao Yu, Hao Wang   +4 more
doaj   +1 more source