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Viral Gene Delivery in Chondrocytes
2022Viral gene transfer, known as transduction, is a powerful research tool for studying the biology of chondrocytes in novel ways and also a technology enabling the use of gene therapy for regenerating cartilage and treating diseases that affect cartilage, such as osteoarthritis.
Christopher V, Nagelli +2 more
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Polymers for viral gene delivery
Expert Opinion on Drug Delivery, 2008The development of viral vectors capable of providing efficient gene transfer in diseased tissues without causing any pathogenic effects is pivotal for overcoming the many challenges facing gene therapy.Immune responses against viral vectors, inadequate gene expression and inefficient targeting to specific cells in vivo are some of the major problems ...
Chun, Wang, Phuong-Truc, Pham
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Annals of the New York Academy of Sciences, 2003
Abstract: Epigenetics represents a new frontier in cancer research. Methylation is the best studied of the epigenetic mechanisms that regulate gene expression. Regulation of gene expression by means of methylation has been reported for tumor suppressor genes, oncogenes, viral promoters, and age‐related genes.
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Abstract: Epigenetics represents a new frontier in cancer research. Methylation is the best studied of the epigenetic mechanisms that regulate gene expression. Regulation of gene expression by means of methylation has been reported for tumor suppressor genes, oncogenes, viral promoters, and age‐related genes.
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Gene Therapy with Viral Vectors
Annual Review of Pharmacology and Toxicology, 2003A key factor in the success of gene therapy is the development of gene delivery systems that are capable of efficient gene transfer in a broad variety of tissues, without causing any pathogenic effect. Currently, viral vectors based on many different viruses have been developed, and their performance and pathogenicity has been evaluated in animal ...
Neeltje A, Kootstra, Inder M, Verma
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Annual Review of Microbiology, 1995
The use of DNA as a drug is both appealing and simple in concept. Indeed in many instances the feasibility of such an approach has been established using model systems. In practical terms, however, the delivery of DNA to human tissues presents a wide variety of problems that differ with each potential therapeutic application. In this review, the design,
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The use of DNA as a drug is both appealing and simple in concept. Indeed in many instances the feasibility of such an approach has been established using model systems. In practical terms, however, the delivery of DNA to human tissues presents a wide variety of problems that differ with each potential therapeutic application. In this review, the design,
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2019
In the previous three chapters we’ve covered the impact our genetics can have on our health. In this final chapter we reverse this and look at the exciting field of gene therapy. In the Viral Gene Therapy simulation, you will learn about the use of modified viruses and how we can manipulate their genetic code to fix mutations inside our own bodies ...
Aaron Gardner +4 more
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In the previous three chapters we’ve covered the impact our genetics can have on our health. In this final chapter we reverse this and look at the exciting field of gene therapy. In the Viral Gene Therapy simulation, you will learn about the use of modified viruses and how we can manipulate their genetic code to fix mutations inside our own bodies ...
Aaron Gardner +4 more
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Gene therapy for viral hepatitis
Expert Opinion on Biological Therapy, 2006Hepatitis B and C infections are two of the most prevalent viral diseases in the world. Existing therapies against chronic viral hepatitis are far from satisfactory due to low response rates, undesirable side effects and selection of resistant viral strains. Therefore, new therapeutic approaches are urgently needed.
Gloria, Gonzalez-Aseguinolaza +5 more
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Non-Viral Gene Delivery Methods
Current Pharmaceutical Biotechnology, 2013Gene delivery has attracted increasing interest as a highly promising therapeutic method to treat various diseases, including both genetic and acquired disorders. Viral-vectors based gene delivery can achieve higher transduction efficiency and long-term gene expression, but they may be associated with some shortcomings, such as immunogenicity ...
Weiwei, Wang +3 more
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Non-viral gene delivery systems
Current Opinion in Biotechnology, 2002Non-viral gene delivery systems have the potential to create viable pharmaceuticals from nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order for these systems to be developed into commercial products, several barriers must be overcome. These include obstacles in manufacturing, formulation and stability.
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Viral Vectors for Gene Transfer
Current Protocols in Mouse Biology, 2018AbstractViral vectors are a promising tool for effective delivery of genetic material into cells. They take advantage of the natural ability of a virus to deliver a genetic payload into cells while being genetically modified such that their ability to replicate is crippled or removed. Here, an updated overview of routinely used viral vectors, including
Yong Hong, Chen +2 more
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