Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A+6 more
core +1 more source
The Role of VP16 in the Life Cycle of Alphaherpesviruses
The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate ...
Dengjian Fan+62 more
doaj +1 more source
Complete genome viral phylogenies suggests the concerted evolution of regulatory cores and accessory satellites. [PDF]
We consider the concerted evolution of viral genomes in four families of DNA viruses. Given the high rate of horizontal gene transfer among viruses and their hosts, it is an open question as to how representative particular genes are of the evolutionary ...
Paolo Marinho de Andrade Zanotto+1 more
doaj +1 more source
A host of factors regulating influenza virus replication. [PDF]
A new series of genetic screens begins to illuminate the interaction between influenza virus and the infected ...
DOUDNA, Jennifer A, Mehle, Andrew
core +3 more sources
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière+15 more
core +1 more source
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19
SARS-CoV-2 infection has spread uncontrollably worldwide while it remains unknown how vulnerable populations, such as Down syndrome (DS) individuals are affected by the COVID-19 pandemic.
Ilario De Toma, Mara Dierssen
doaj +1 more source
Zika virus infection reprograms global transcription of host cells to allow sustained infection. [PDF]
Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection.
Bansal, Vikas+5 more
core +2 more sources
The Transcriptional Landscape of Marek’s Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes [PDF]
Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and poses a serious threat to poultry health. In infected animals, MDV efficiently replicates in B cells in various lymphoid organs.
Bertzbach, Luca D.+7 more
core +2 more sources
Cotesia plutellae (= vestalis) bracovirus (CpBV) is symbiotic to an endoparasitoid wasp, C. plutellae, and plays crucial roles in parasitism against the diamondback moth, Plutella xylostella.
Yonggyun Kim, Sunil Kumar
doaj +1 more source
Viruses of the phylum Nucleocytoviricota, or nucleo-cytoplasmic large DNA viruses (NCLDVs), undergo a cytoplasmic or nucleo-cytoplasmic cycle, the latter of which involves both nuclear and cytoplasmic compartments to proceed viral replication ...
Ruixuan Zhang+3 more
doaj +1 more source