Results 41 to 50 of about 4,146,284 (322)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Investigación de dos casos complejos de relación biológica
Iatreia, 2010 Presentamos dos casos complejos de investigación de la relación biológica con un diagnóstico conclusivo. El primero corresponde al caso de una menor sin madre, con presunto padre fallecido y como referencias solo se disponía de la presunta abuela paterna
Diana de Aguirre +5 more
doaj
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Gene set bagging for estimating replicability of gene set analyses [PDF]
, 2013 Background: Significance analysis plays a major role in identifying and ranking genes, transcription factor binding sites, DNA methylation regions, and other high-throughput features for association with disease. We propose a new approach, called gene set bagging, for measuring the stability of ranking procedures using predefined gene sets.
arxiv +1 more source
Frontiers in PharmacologyAimNimodipine has shown neuroprotective effects in several studies; however, the specific targets and mechanisms remain unclear. This study aims to explore the potential targets and mechanisms of nimodipine in the treatment of neurodegenerative diseases (
Shuang Zheng +7 more
doaj +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Evolutionary and topological properties of gene modules and driver mutations in a leukemia gene regulatory network [PDF]
, 2015 The diverse, specialized genes in today's lifeforms evolved from a common core of ancient, elementary genes. However, these genes did not evolve individually: gene expression is controlled by a complex network of interactions, and alterations in one gene may drive reciprocal changes in its proteins' binding partners.
arxiv +1 more source
Iatreia, 2010 Los marcadores genéticos tipo microsatélites del Cromosoma X (X-STR) han recibido creciente atención tan sólo en los últimos 10 años. Se ha demostrado su gran capacidad para aclarar casos complejos de parentesco, tales como abuela paterna - nieta ...
Juan José Builes +6 more
doaj
A new AAV tool for highly preferentially targeting hippocampal CA2
Molecular Brain, 2023 Mice hippocampus contains three prominent subregions, CA1, CA3 and DG and is well regarded as an essential multiple task processor for learning, memory and cognition based on tremendous studies on these three subregions.
Siqi Peng +8 more
doaj +1 more source