Results 21 to 30 of about 39,114 (250)

Molecular study of developmental sex disorders in children

Egyptian Journal of Medical Human Genetics, 2015
Background: Sex determination and differentiation in humans are processes that involve the interaction of several genes such as SRY, SOX9 genes which are important in the development of the male genital system.
Soheir S. AboElella, Maha A.M. Tawfik, Wafaa moustafa M. Abo El-fotoh   +2 more
doaj   +1 more source

Regulation of multiple renin–angiotensin system genes by Sry [PDF]

Journal of Hypertension, 2010
We demonstrated that the Sry gene complex on the spontaneously hypertensive rat (SHR) Y chromosome is a candidate locus for hypertension that accounts for the SHR Y chromosome blood pressure effect. All rat strains examined to date share six Sry loci, and a seventh Sry locus (Sry3) appears to be unique to SHR male rats.
Amy, Milsted, Adam C, Underwood, Jeff, Dunmire, Helen L, DelPuerto, Almir S, Martins, Daniel L, Ely, Monte E, Turner   +6 more
openaire   +2 more sources

From Rat to Human: Regulation of Renin-Angiotensin System Genes by Sry

International Journal of Hypertension, 2012
The testis determining protein, Sry, has functions outside of testis determination. Multiple Sry loci are found on the Y-chromosome. Proteins from these loci have differential activity on promoters of renin-angiotensin system genes, possibly contributing
Jeremy W. Prokop, Ingrid Kazue Mizuno Watanabe, Monte E. Turner, Adam C. Underwood, Almir S. Martins, Amy Milsted   +5 more
doaj   +1 more source

A family case of fertile human 45,X,psu dic(15;Y) males [PDF]

, 2006
We report on a familial case including four male probands from three generations with a 45,X,psu dic(15;Y)(p11.2;q12) karyotype. 45,X is usually associated with a female phenotype and only rarely with maleness, due to translocation of small Y chromosomal
Andersson M, Baumstark A, Buonadonna AL, C.S. Nagarajappa, Callen DF, Charchar FJ, Fracarro M, Freije D, Gal A, Haaf T, Hsu TC, I. Hansmann, I. Palaniappan, Koiffmann CP, Ma NS, Maserati E, Matthey R, N. Chandra, P.M. Gopinath, R. Wimmer, Ried T, Schempp W, Schiebel K, Schmid M, Siffroi JP, Subrt I, Tiemeier DC, W. Schempp, Weber B, White LM   +29 more
core   +1 more source

Duplication of SOX3 in an SRY-negative 46,XX male with prostatic utricle: case report and literature review

BMC Medical Genomics, 2022
Background 46,XX male disorders of sex development are rare. Approximately 80% of cases of testicular tissue differentiation may be due to translocation of SRY to the X chromosome or an autosome. SRY-negative 46,XX males show overexpression of pro-testis
Jiansheng Wei, Changrong Liu, Minyan Zhang, Shen Liu, Junjie Fu, Peng Lin   +5 more
doaj   +1 more source

The study of a hermaphroditic sheep caused by a mutation in the promoter of SRY gene

Veterinary and Animal Science, 2023
In mammals, sex-determining region Y (SRY) gene plays vital role as a transcription factor to regulate the expression of the genes contributing to development of male genitals.
Farid Heidari, Mohaddeseh Rahbaran, Asieh Mirzaei, Mehran Mozafari Tabatabaei, Sara Shokrpoor, Frouzandeh Mahjoubi, Mehdi Shams Ara, Vahid Akbarinejad, Faramarz Gharagozloo   +8 more
doaj   +1 more source

Sex determination from dental pulp DNA among Egyptians

Egyptian Journal of Forensic Sciences, 2017
Background A great challenge arises when sex determination of human remains is needed, especially when only, bone fragments or isolated teeth are available; such as in mass disasters.
M. Kholief, S. El Shanawany, R. Gomaa
doaj   +1 more source

Turner syndrome and associated problems in turkish children: A multicenter study [PDF]

, 2015
Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls.
Abacı, A., Abalı, S., Adal, E., Akın, L., Akıncı, A., Akyürek, N., Andıran, N., Anık, A., Atabek, M.E., Ataş, A., Aydın, B.K., Açıkel, C., Baş, F., Baş, S., Baş, V.N., Bereket, A., Binay, Ç., Bolu, S., Bondy, C., Bulan, K., Büyükinan, M., Can, H.D., Cinaz, P., Darcan, Ş., Darendeliler, F., Demir, K., Demirbilek, H., Demirel, F., Doğan, D., Doğan, M., Döneray, H., Dündar, B., Eklioğlu, B.S., Emeksiz, H.C., Ercan, O., Eren, E., Ersoy, B., Evliyaoğlu, O., Fidancı, K., Gökşen, D., Gül, D., Gürbüz, F., Hatun, Ş., Kaba, S., Kara, C., Karagüzel, G., Keskin, M., Kızılay, D., Orbak, Z., Pirgon, Ö., Polat, A., Poyrazoğlu, Ş., Sarı, E., Sağlam, H., Tarım, Ö., Tepe, D., Topaloğlu, A.K., Turan, S., Yeşilkaya, E., Yüksel, B., Çakır, E.D., Çatlı, G., Çelik, N., Çizmecioğlu, F., Ökten, A., Önal, H., Özbek, M.N., Özen, S., Özgen, T., Özhan, Bayram, Özkan, B., Ünüvar, T., Şen, Y., Şimşek, E.   +73 more
core   +1 more source

Clinicopathological significance of loss of Y chromosome in male meningiomas. [PDF]

J Pathol
Abstract Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high‐grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in various male‐predominant tumors, a limited number of studies have evaluated their role in meningiomas.
Sakaguchi M, Horie M, Ito Y, Tanaka S, Ikeda H, Nakada M, Yoshizawa A, Maeda D.   +7 more
europepmc   +2 more sources

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]

, 2009
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H., Baker, P.J., Huhtaniemi, I., Morris, I.D., O'Shaughnessy, P.J.   +4 more
core   +1 more source