Results 1 to 10 of about 407 (114)
Characterization of
Genetics Selection Evolution, 2001 In mammals, testis determination is under the control of the sex-determining gene SRY. This Y-linked gene encodes a protein with a DNA binding domain similar to those found in high-mobility-group proteins.
Kudo Toshiyuki +8 more
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Journal of Reproduction and Development, 1996 In mammals, the SRY (the sex determining region on the Y; Sry in the mouse) gene is responsible for the function of TDF (testis determining factor; Tdy in the mouse) locus, and plays a key role in the sex determination. In the mouse, the Sry open reading frame (ORF) is flanked at either end by a large inverted repeat, causing the formation of ...
Keitaro Yamanouchi +2 more
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Evolution of the Sry genes [PDF]
Molecular Biology and Evolution, 1997 Existing DNA sequence data on the Sry gene, the mammalian sex-determining locus in the Y chromosome, were analyzed for primates, rodents, and bovids. In all three taxonomic groups, the terminal sequences evolved faster than the HMG (high mobility group) boxes, and this applies both to synonymous (Ks) and nonsynonymous (Ka) nucleotide substitutions ...
P, Pamilo, R J, O'Neill
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Gene expression and functional abnormalities in XX/Sry Leydig cells
Scientific Reports, 2021 The SRY gene induces testis development even in XX individuals. However, XX/Sry testes fail to produce mature sperm, due to the absence of Y chromosome carrying genes essential for spermatogenesis.
Shogo Yanai +10 more
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Current Issues in Molecular Biology, 2023 Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer and the fifth cause of cancer-related deaths worldwide with a poor 5-year survival.
Tomasz Kolenda +11 more
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Dissociable effects of Sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. [PDF]
PLoS ONE, 2013 Whilst gonadal hormones can substantially influence sexual differentiation of the brain, recent findings have suggested that sex-linked genes may also directly influence neurodevelopment. Here we used the well-established murine 'four core genotype' (FCG)
Eleni Kopsida +4 more
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A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis. [PDF]
PLoS ONE, 2016 SRY-mutation-caused sex reversal is a rare disease and mostly associated with a de novo mutation since the patients with defective SRY is infertile. There are many reports about SRY-mutation associated 46, XY ovarian disorder of sex development (DSD ...
Wufang Fan +8 more
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The evolutionary process of mammalian sex determination genes focusing on marsupial SRYs
BMC Evolutionary Biology, 2018 Background Maleness in mammals is genetically determined by the Y chromosome. On the Y chromosome SRY is known as the mammalian male-determining gene. Both placental mammals (Eutheria) and marsupial mammals (Metatheria) have SRY genes.
Yukako Katsura +4 more
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THE SRY GENE VARIATIONS AMONGST SELECTED MADURA CATTLE POPULATIONS
Jurnal Kedokteran Hewan, 2018 The aim of this study was to determine the diversity of the sex-determining region Y (SRY) gene in Madura cattle bulls that had specifically selected for the production of frozen semen.
Koko Wisnu Prihatin +2 more
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Cbx2, a Polycomb Group Gene, Is Required for Sry Gene Expression in Mice [PDF]
Endocrinology, 2012 Mice lacking the function of the polycomb group protein CBX2 (chromobox homolog 2; also known as M33) show defects in gonadal, adrenal, and splenic development. In particular, XY knockout (KO) mice develop ovaries but not testes, and the gonads are hypoplastic in both sexes.
Katoh-Fukui, Yuko +12 more
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