Results 41 to 50 of about 39,114 (250)
Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. [PDF]
, 2019 In laboratory strains of zebrafish, sex determination occurs in the absence of a typical sex chromosome and it is not known what regulates the proportion of animals that develop as males or females.
Bruce W. Draper +8 more
core +1 more source
Journal of Reproduction and Development, 1996 In mammals, the SRY (the sex determining region on the Y; Sry in the mouse) gene is responsible for the function of TDF (testis determining factor; Tdy in the mouse) locus, and plays a key role in the sex determination. In the mouse, the Sry open reading frame (ORF) is flanked at either end by a large inverted repeat, causing the formation of ...
Osamu HIROTA +7 more
openaire +2 more sources
Copy number variations of five Y chromosome genes in donkeys [PDF]
Archives Animal Breeding, 2017 In mammals, the Y chromosome plays a pivotal role in male sex determination and is essential for normal sperm production. A number of studies were conducted on Y chromosome genes of various species and identified single-copy and multi-copy genes ...
H. Han +5 more
doaj +1 more source
Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs [PDF]
, 2019 In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the ...
Payan-Carreira, Rita
core +1 more source
, 2012 Multicellular animals are a diverse lot, with widely varied body plans and lifestyles. One feature they share, however, is a nearly universal reliance on sexual reproduction for species propagation.
Gamble, Tony
core +1 more source
Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq [PDF]
, 2016 © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. Cooperative binding of transcription factors is known to be important in the regulation of gene expression programs conferring cellular identities.
Chang, Yiming K +8 more
core +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
BMC Cardiovascular Disorders, 2007 Background Our laboratory has shown that a locus on the SHR Y chromosome increases blood pressure (BP) in the SHR rat and in WKY rats that had the SHR Y chromosome locus crossed into their genome (SHR/y rat).
Ciotti Mat +5 more
doaj +1 more source
Mixed gonadal dysgenesis in 45,X Turner syndrome with gene [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2015 Turner syndrome is the most common chromosomal disorder in girls. Various phenotypic features show depending upon karyotype from normal female through ambiguous genitalia to male.
Jae Yeop Jung +6 more
doaj +1 more source