Results 41 to 50 of about 1,694,828 (235)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Sry delivery to the adrenal medulla increases blood pressure and adrenal medullary tyrosine hydroxylase of normotensive WKY rats

BMC Cardiovascular Disorders, 2007
Background Our laboratory has shown that a locus on the SHR Y chromosome increases blood pressure (BP) in the SHR rat and in WKY rats that had the SHR Y chromosome locus crossed into their genome (SHR/y rat).
Ciotti Mat, Bertram Jason, Milsted Amy, Ely Daniel, Dunphy Gail, Turner Monte E   +5 more
doaj   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Conditional strategies to study gene function during gonadal development in mammals. [PDF]

, 2008
Sexual development in mammals involves a complex cascade of genetic events. These begin with a cell fate decision, whether to make Sertoli or follicle cells, that gives rise to the development of a male or female gonad, which is controlled by the testis ...
Tye, A.J.
core  

Trastorno del desarrollo sexual testicular 46,XX en evaluación de la fertilidad masculina. Presentación de caso

Medimay, 2018
El trastorno del desarrollo sexual testicular 46,XX es una causa infrecuente de infertilidad masculina. Con el objetivo de reportar un caso diagnosticado en la consulta de genética clínica del Centro Provincial de Genética Médica de Mayabeque, se ...
Daniel Quintana Hernández, Ainadys Herrera Luis, Ernesto R. Noa Domínguez, Danisbel Quintana Mora   +3 more
doaj   +4 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Analyse der transkriptionellen Regulation des humanen endogenen Retrovirus HTDV/HERV-K [PDF]

, 2004
Das humane Genom besteht zu etwa 8% aus retroviralen Sequenzen. Davon sind ca. 1-2% dem humanen endogenen Retrovirus K (HERV-K) zuzuordnen. Das Virus ist mit ca. 30-50 Proviren und ca. 10.000 sLTRs im humanen Genom vertreten.
Kraft, Martin
core  

SRY and mammalian sex determination

, 1996
This chapter discusses the understanding of the biology of sry and sex determination particularly what is known of the biochemical basis of sry function and its relationship to the other genes in the sex determination pathway.
Andy Greenfield, Greenfield, A., Peter Koopman, Koopman, P.   +3 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Prevalence of SRY and DAX-1 gene deletion in patients with Cryptorchidism and Hypospadias – A Pilot study in North Indian Children

Asian Journal of Medical Sciences, 2015
Background: Cryptorchidism and hypospadias are common problems in males attending the pediatric surgery clinic. These two abnormalities are also associated with genetic syndromes/disorders of sexual development (DSD).
Krishna Mohan Gulla
doaj   +1 more source