Results 41 to 50 of about 23,557 (205)

Detection and Analysis of 12 Suspected Amelogenin Allelic Loss Cases [PDF]

Fayixue Zazhi, 2018
Objective To observe and analyse the Amelogenin allelic loss in parent-child identification cases, and to explore the type and mechanism of Amelogenin allelic loss as well as its influence on gender identification and solutions.
BI Jie, CHANG Jing-jing, YU Chun-ying
doaj   +1 more source

Regulation of CATSPER1 expression by the testis-determining gene SRY

PLOS ONE, 2018
El gen CATSPER1 codifica una subunidad formadora de poros y sensible al pH del canal permeable CatSper Ca2+, una proteína en el flagelo esencial para la hiperactivación de los espermatozoides. Estudios previos han demostrado que el promotor del gen Catsper1 murino está regulado por diferentes proteínas Sox.
Aleida Olivares, Adriana Hernández-Reyes, Ricardo Felix, Ángela Forero, Minerva Mata‐Rocha, Javier Hernández‐Sánchez, Ivanaldo Santos, Charmina Aguirre-Alvarado, Norma Oviedo   +8 more
openaire   +4 more sources

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Steroidogenic factor-1 (SF-1) gene mutation as a frequent cause of primary amenorrhea in 46,XY female adolescents with low testosterone concentration

Reproductive Biology and Endocrinology, 2010
Background Primary amenorrhea due to 46,XY disorders of sex differentiation (DSD) is a frequent reason for consultation in endocrine and gynecology clinics.
Servant Nadège, Raingeard Isabelle, Lespinasse James, Frances Anne-Marie, Polak Michel, Thibaud Elisabeth, Zenaty Delphine, Leprieur Elodie, Philibert Pascal, Audran Françoise, Paris Françoise, Sultan Charles   +11 more
doaj   +1 more source

Differentially expressed genes in the testes from early to mature development of banana shrimp (Fenneropenaeus merguiensis).

PLoS ONE, 2023
Banana shrimp (Fenneropenaeus merguiensis) is an economically important species in Thailand owing to the high value of globally exported frozen brine shrimps. However, the regulatory mechanisms governing spermatogenesis and testicular development in this
Uraipan Saetan, Wilaiwan Chotigeat
doaj   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

PCR amplification, sequencing, and in silico analysis of holandric genes TSPYand SRY in Nili Ravi buffalo

Indian Journal of Animal Sciences
The present work has been designed to study the evolutionary perspectives of two important holandric genes, namely, testis-specific protein, Y-encoded (TSPY), and sex determining region, Y-encoded (SRY) in Nili Ravi buffalo.
SANDEEP SINGH, RANBIR SINGH, C S MUKHOPADHYAY   +2 more
doaj   +1 more source

SRY-related genes in the genome of the rice field eel (Monopterus albus)

Genetics Selection Evolution, 2002
The mammalian sex determining gene, SRY, is the founding member of the new growing family of Sox (SRY-like HMG-box gene) genes. Sox genes encode transcription factors with diverse roles in development, and a few of them are involved in sex determination ...
Cooper Richard K, Guo Yiqing, Zhang Quiyang, Cheng Hanhua, Zhou Rongjia, Tiersch Terrence R   +5 more
doaj   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Specificity of Key Sex Determination Genes in a Mammal with Ovotestes: The European Mole Talpa europaea

Animals
Here, for the first time, the structure of genes involved in sex determination in mammals (full Sry and partial Rspo1, Eif2s3x, and Eif2s3y) was analyzed for the European mole Talpa europaea with ovotestes in females.
Alexey Bogdanov, Maria Sokolova, Irina Bakloushinskaya   +2 more
doaj   +1 more source