Results 11 to 20 of about 1,694,828 (235)

The Sex-Determining Factors SRY and SOX9 Regulate Similar Target Genes and Promote Testis Cord Formation during Testicular Differentiation [PDF]

Cell Reports, 2014
Male sex determination is mediated sequentially by sex-determining region Y (SRY) and related SRY-box 9 (SOX9) transcription factors. To understand the gene regulatory hierarchy for SRY and SOX9, a series of chromatin immunoprecipitation and whole-genome
Yunmin Li, Ming Zheng, Yun-Fai Chris Lau   +2 more
doaj   +2 more sources

Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex-reversed patients

Brazilian Journal of Medical and Biological Research, 2004
In most mammals, male development is triggered by the transient expression of the SRY gene, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad.
S. Domenice, R.V. Corrêa, E.M.F. Costa, M.Y. Nishi, E. Vilain, I.J.P. Arnhold, B.B. Mendonca   +6 more
doaj   +2 more sources

From Rat to Human: Regulation of Renin-Angiotensin System Genes by Sry [PDF]

International Journal of Hypertension, 2012
The testis determining protein, Sry, has functions outside of testis determination. Multiple Sry loci are found on the Y-chromosome. Proteins from these loci have differential activity on promoters of renin-angiotensin system genes, possibly contributing
Jeremy W. Prokop, Ingrid Kazue Mizuno Watanabe, Monte E. Turner, Adam C. Underwood, Almir S. Martins, Amy Milsted   +5 more
doaj   +2 more sources

Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat

Biology of Sex Differences, 2020
Background The commonly used laboratory rat, Rattus norvegicus, is unique in having multiple Sry gene copies found on the Y chromosome, with different copies encoding amino acid variations that influence the resulting protein function.
Jeremy W. Prokop, Surya B. Chhetri, J. Edward van Veen, Xuqi Chen, Adam C. Underwood, Katie Uhl, Melinda R. Dwinell, Aron M. Geurts, Stephanie M. Correa, Arthur P. Arnold   +9 more
doaj   +2 more sources

PCR amplification, sequencing, and in silico analysis of holandric genes TSPYand SRY in Nili Ravi buffalo [PDF]

Indian Journal of Animal Sciences
The present work has been designed to study the evolutionary perspectives of two important holandric genes, namely, testis-specific protein, Y-encoded (TSPY), and sex determining region, Y-encoded (SRY) in Nili Ravi buffalo.
SANDEEP SINGH, RANBIR SINGH, C S MUKHOPADHYAY   +2 more
doaj   +2 more sources

Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. [PDF]

PLoS Biology, 2006
The genes encoding members of the wingless-related MMTV integration site (WNT) and fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation in many fields of cells during development.
Yuna Kim, Akio Kobayashi, Ryohei Sekido, Leo DiNapoli, Jennifer Brennan, Marie-Christine Chaboissier, Francis Poulat, Richard R Behringer, Robin Lovell-Badge, Blanche Capel   +9 more
doaj   +2 more sources

SRY-related genes in the genome of the rice field eel (Monopterus albus) [PDF]

Genetics Selection Evolution, 2002
The mammalian sex determining gene, SRY, is the founding member of the new growing family of Sox (SRY-like HMG-box gene) genes. Sox genes encode transcription factors with diverse roles in development, and a few of them are involved in sex determination ...
Cooper Richard K, Guo Yiqing, Zhang Quiyang, Cheng Hanhua, Zhou Rongjia, Tiersch Terrence R   +5 more
doaj   +2 more sources

Mutations in SRY and WT1 genes required for gonadal development are not responsible for XY partial gonadal dysgenesis

Brazilian Journal of Medical and Biological Research, 2005
The WT1 transcription factor regulates SRY expression during the initial steps of the sex determination process in humans, activating a gene cascade leading to testis differentiation.
E.B. Tagliarini, J.G. Assumpção, M.R. Scolfaro, M.P. de Mello, A.T. Maciel-Guerra, G. Guerra Júnior, C. Hackel   +6 more
doaj   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source