Results 11 to 20 of about 23,557 (205)

Quantitative dissection of sexual dimorphism in mice through Y-linked gene knockouts and multivariate phenotyping [PDF]

Scientific Reports
Sexual dimorphism (SDM) is regulated by sex chromosomes, yet the specific contribution of individual genes remains unclear. To address this, we conducted a comprehensive phenotyping analysis to investigate the roles of Y chromosome-linked genes in SDM ...
Nobuhiko Tanaka, Kento Miura, Ai Ozaki, Yasuyo Kozawa, Masaru Tamura, Atsuo Ogura, Shogo Matoba   +6 more
doaj   +2 more sources

Amplification of Ultra-Trace DNA from Early Sheep Embryos Based on qPCR: Establishing a Gender Identification System [PDF]

Biology
The ability to identify and control the sex of embryos holds significant commercial implications for livestock production. Due to the high costs and instability of detection methods, it is necessary to establish a time-saving, effective, simple, and ...
Peng Niu, Weikun Tao, Fei Huang, Xiaopeng Li, Xueyan Wang, Jie Wang, Qinghua Gao, Di Fang   +7 more
doaj   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

The Sex-Determining Factors SRY and SOX9 Regulate Similar Target Genes and Promote Testis Cord Formation during Testicular Differentiation

Cell Reports, 2014
Male sex determination is mediated sequentially by sex-determining region Y (SRY) and related SRY-box 9 (SOX9) transcription factors. To understand the gene regulatory hierarchy for SRY and SOX9, a series of chromatin immunoprecipitation and whole-genome
Yunmin Li, Ming Zheng, Yun-Fai Chris Lau   +2 more
doaj   +1 more source

Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat

Biology of Sex Differences, 2020
Background The commonly used laboratory rat, Rattus norvegicus, is unique in having multiple Sry gene copies found on the Y chromosome, with different copies encoding amino acid variations that influence the resulting protein function.
Jeremy W. Prokop, Surya B. Chhetri, J. Edward van Veen, Xuqi Chen, Adam C. Underwood, Katie Uhl, Melinda R. Dwinell, Aron M. Geurts, Stephanie M. Correa, Arthur P. Arnold   +9 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Mutations in the SRY, DAX1, SF1 and WNT4 genes in Brazilian sex-reversed patients

Brazilian Journal of Medical and Biological Research, 2004
In most mammals, male development is triggered by the transient expression of the SRY gene, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad.
S. Domenice, R.V. Corrêa, E.M.F. Costa, M.Y. Nishi, E. Vilain, I.J.P. Arnhold, B.B. Mendonca   +6 more
doaj   +1 more source

Molecular study of developmental sex disorders in children

Egyptian Journal of Medical Human Genetics, 2015
Background: Sex determination and differentiation in humans are processes that involve the interaction of several genes such as SRY, SOX9 genes which are important in the development of the male genital system.
Soheir S. AboElella, Maha A.M. Tawfik, Wafaa moustafa M. Abo El-fotoh   +2 more
doaj   +1 more source

From Rat to Human: Regulation of Renin-Angiotensin System Genes by Sry

International Journal of Hypertension, 2012
The testis determining protein, Sry, has functions outside of testis determination. Multiple Sry loci are found on the Y-chromosome. Proteins from these loci have differential activity on promoters of renin-angiotensin system genes, possibly contributing
Jeremy W. Prokop, Ingrid Kazue Mizuno Watanabe, Monte E. Turner, Adam C. Underwood, Almir S. Martins, Amy Milsted   +5 more
doaj   +1 more source

Regulation of multiple renin–angiotensin system genes by Sry [PDF]

Journal of Hypertension, 2010
We demonstrated that the Sry gene complex on the spontaneously hypertensive rat (SHR) Y chromosome is a candidate locus for hypertension that accounts for the SHR Y chromosome blood pressure effect. All rat strains examined to date share six Sry loci, and a seventh Sry locus (Sry3) appears to be unique to SHR male rats.
Amy, Milsted, Adam C, Underwood, Jeff, Dunmire, Helen L, DelPuerto, Almir S, Martins, Daniel L, Ely, Monte E, Turner   +6 more
openaire   +2 more sources