The study of a hermaphroditic sheep caused by a mutation in the promoter of SRY gene [PDF]
Veterinary and Animal Science, 2023 In mammals, sex-determining region Y (SRY) gene plays vital role as a transcription factor to regulate the expression of the genes contributing to development of male genitals.
Farid Heidari +8 more
doaj +2 more sources
Gene expression and functional abnormalities in XX/Sry Leydig cells [PDF]
Scientific Reports, 2021 The SRY gene induces testis development even in XX individuals. However, XX/Sry testes fail to produce mature sperm, due to the absence of Y chromosome carrying genes essential for spermatogenesis.
Shogo Yanai +10 more
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Characterization of
Genetics Selection Evolution, 2001 In mammals, testis determination is under the control of the sex-determining gene SRY. This Y-linked gene encodes a protein with a DNA binding domain similar to those found in high-mobility-group proteins.
Kudo Toshiyuki +8 more
doaj +4 more sources
Mixed gonadal dysgenesis in 45,X Turner syndrome with gene [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2015 Turner syndrome is the most common chromosomal disorder in girls. Various phenotypic features show depending upon karyotype from normal female through ambiguous genitalia to male.
Jae Yeop Jung +6 more
doaj +2 more sources
Contemporary Clinical Dentistry, 2019 Purpose: Sex determination becomes the first priority by a forensic investigator in the process of identification of bodies mutilated beyond recognition due to mass disasters.
Ruheena Khan +2 more
doaj +2 more sources
SRY gene isolation from teeth for forensic gender identification-An observational study. [PDF]
PLoS ONEPersonal identification in forensics is possible with gender determination using DNA (deoxyribonucleic acid) analysis. DNA isolation from teeth samples subjected to extreme temperatures has been shown to predict the gender of the deceased.
Prathibha Prasad +5 more
doaj +2 more sources
Regulation of CATSPER1 expression by the testis-determining gene SRY. [PDF]
PLoS ONE, 2018 CATSPER1 gene encodes a pore-forming and pH-sensing subunit of the CatSper Ca2+- permeable channel, a protein in the flagellum essential for sperm hyperactivation.
Aleida Olivares +8 more
doaj +4 more sources
SRY mediates male-specific susceptibility to acute liver injury [PDF]
Cell Communication and SignalingBackground and aims Sex-determining region on the Y chromosome (SRY), a male-specific gene, can promote the development of various liver diseases including liver fibrosis, hepatocellular carcinoma.
Meng-yun Ke +9 more
doaj +2 more sources
Sex-determining Region of Y-gene Translocation and 46,XX Testicular Disorders of Sex Development: Cytogenetic and Molecular Insights into Male Infertility [PDF]
Journal of Human Reproductive Sciences46,XX male syndrome, also known as De la Chapelle syndrome, is a rare condition characterised by a discordance between chromosomal sex and male phenotypic presentation.
Pritti K Priya +3 more
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Clinicopathological significance of loss of Y chromosome in male meningiomas. [PDF]
J PatholAbstract Male meningiomas, comprising approximately 30% of all meningiomas, are more frequently high‐grade and associated with poorer clinical outcomes compared to their female counterparts. Although Y chromosome alterations have been studied in various male‐predominant tumors, a limited number of studies have evaluated their role in meningiomas.
Sakaguchi M +7 more
europepmc +2 more sources