Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs. [PDF]
Proc Natl Acad Sci U S A, 2021 Kurtz S +6 more
europepmc +2 more sources
Amplification of Ultra-Trace DNA from Early Sheep Embryos Based on qPCR: Establishing a Gender Identification System [PDF]
BiologyThe ability to identify and control the sex of embryos holds significant commercial implications for livestock production. Due to the high costs and instability of detection methods, it is necessary to establish a time-saving, effective, simple, and ...
Peng Niu +7 more
doaj +2 more sources
Frontiers in Neuroscience, 2021 Fetal alcohol exposure (FAE) causes various neurodevelopmental deficits in offspring, including reduced expression of the stress regulatory proopiomelanocortin (Pomc) gene and an elevated stress response for multiple generations via the male germline ...
Omkaram Gangisetty +2 more
doaj +1 more source
Evolution of the Sry genes [PDF]
Molecular Biology and Evolution, 1997 Existing DNA sequence data on the Sry gene, the mammalian sex-determining locus in the Y chromosome, were analyzed for primates, rodents, and bovids. In all three taxonomic groups, the terminal sequences evolved faster than the HMG (high mobility group) boxes, and this applies both to synonymous (Ks) and nonsynonymous (Ka) nucleotide substitutions ...
P, Pamilo, R J, O'Neill
openaire +2 more sources
Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression. [PDF]
PLoS ONE, 2012 SRY is a sex-determining gene that encodes a transcription factor, which triggers male development in most mammals. The molecular mechanism of SRY action in testis determination is, however, poorly understood.
Zhen Xu +11 more
doaj +1 more source
Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9. [PDF]
PLoS ONE, 2012 A major event in mammalian male sex determination is the induction of the testis determining factor Sry and its downstream gene Sox9. The current study provides one of the first genome wide analyses of the downstream gene binding targets for SRY and SOX9
Ramji K Bhandari +2 more
doaj +1 more source
Mutations in the testis-specific enhancer of SOX9 in the SRY independent sex-determining mechanism in the genus Tokudaia. [PDF]
PLoS ONE, 2014 SRY (sex-determining region Y) is widely conserved in eutherian mammals as a sex-determining gene located on the Y chromosome. SRY proteins bind to the testis-specific enhancer of SOX9 (TES) with SF1 to upregulate SOX9 expression in undifferentiated ...
Ryutaro Kimura +3 more
doaj +1 more source
Applying real-time quantitative PCR to diagnosis of freemartin in Holstein cattle by quantifying SRY gene: a comparison experiment [PDF]
PeerJ, 2018 Background Freemartinism generally occurs in female offspring of dizygotic twins in a mixed-sex pregnancy. Most bovine heterosexual twin females are freemartins. However, about 10% of bovine heterosexual twin females are fertile.
Qinghua Qiu +5 more
doaj +2 more sources
The evolutionary process of mammalian sex determination genes focusing on marsupial SRYs
BMC Evolutionary Biology, 2018 Background Maleness in mammals is genetically determined by the Y chromosome. On the Y chromosome SRY is known as the mammalian male-determining gene. Both placental mammals (Eutheria) and marsupial mammals (Metatheria) have SRY genes.
Yukako Katsura +4 more
doaj +1 more source
OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program [PDF]
, 2019 A paradox is posed by metazoan gene-regulatory networks (GRNs) that are robust yet evolvable. Insight may be obtained through studies of bistable genetic circuits mediating developmental decisions. A model in organogenesis is provided by the sex-specific
Chen, Yen-Shan +3 more
core +1 more source