Results 131 to 140 of about 7,627,088 (344)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Nature
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4.
Ken Suzuki, K. Hatzikotoulas, L. Southam, Henry J. Taylor, Xianyong Yin, Kimberly M. Lorenz, Ravi Mandla, A. Huerta-Chagoya, Giorgio E. M. Melloni, S. Kanoni, N. W. Rayner, O. Bocher, A. Arruda, K. Sonehara, S. Namba, Simon Lee, Michael H. Preuss, Lauren E. Petty, Philip H. Schroeder, Brett R. Vanderwerff, M. Kals, F. Bragg, Kuang Lin, Xiuqing Guo, Weihua Zhang, Jie Yao, Young Jin Kim, M. Graff, F. Takeuchi, J. Nano, Amel Lamri, M. Nakatochi, Sanghoon Moon, Robert A. Scott, J. Cook, Jung-Jin Lee, Ian Pan, D. Taliun, E. Parra, Jin-Fang Chai, L. Bielak, Y. Tabara, Y. Hai, G. Thorleifsson, N. Grarup, T. Sofer, M. Wuttke, C. Sarnowski, C. Gieger, Darryl Nousome, S. Trompet, S. Kwak, J. Long, Meng Sun, L. Tong, Wei-Min Chen, Suraj S Nongmaithem, R. Noordam, V. J. Lim, C. H. Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, L. Raffield, B. Prins, A. Nicolas, L. Yanek, Guanjie Chen, J. Brody, E. Kabagambe, Ping An, Anny H. Xiang, Hyeok Sun Choi, B. Cade, Jingyi Tan, K. Broadaway, A. Williamson, Zoha Kamali, J. Cui, Manonanthini Thangam, Linda S. Adair, A. Adeyemo, C. Aguilar-Salinas, T. Ahluwalia, S. Anand, Alain G. Bertoni, J. Bork-Jensen, Ivan Brandslund, Thomas A. Buchanan, C. Burant, A. Butterworth, M. Canouil, Juliana C N Chan, Li Chang, M. Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengmin Chen, Lee-Ming Chuang, Mary Cushman, J. Danesh, Swapan K. Das, H. D. de Silva, G. Dedoussis, Latchezar Dimitrov, A. Doumatey, S. Du, Qing Duan, K.-U. Eckardt, L. Emery, Daniel S. Evans, Michele K. Evans, K. Fischer, James S Floyd, Ian Ford, Oscar H. Franco, T. Frayling, B. Freedman, P. Genter, H. Gerstein, V. Giedraitis, C. González‐Villalpando, M. González-Villalpando, P. Gordon-Larsen, Myron Gross, Lindsay A Guare, S. Hackinger, L. Hakaste, Sohee Han, A. Hattersley, C. Herder, M. Horikoshi, A. Howard, Willa A. Hsueh, Mengna Huang, Wei Huang, Y. Hung, M. Y. Hwang, C. Hwu, S. Ichihara, M. Ikram, M. Ingelsson, Md. Tariqul Islam, M. Isono, Hye-Mi Jang, F. Jasmine, Guozhi Jiang, J. Jonas, T. Jørgensen, Frederick K. Kamanu, Fouad R. Kandeel, A. Kasturiratne, Tomohiro Katsuya, V. Kaur, T. Kawaguchi, Jacob M. Keaton, Abel N. Kho, C. Khor, M. Kibriya, Duk-Hwan Kim, F. Kronenberg, J. Kuusisto, Kristi Läll, Leslie A. Lange, K. Lee, Myung-Shik Lee, N. Lee, Aaron Leong, Liming Li, Yun Li, R. Li-Gao, Symen Ligthart, Cecilia M. Lindgren, A. Linneberg, Ching-Ti Liu, Jianjun Liu, A. Locke, T. Louie, J. Luan, A. Luk, Xi Luo, Jun Lv, J. Lynch, V. Lyssenko, Shiro Maeda, Vasiliki Mamakou, S. R. Mansuri, Koichi Matsuda, T. Meitinger, Olle Melander, A. Metspalu, Huan Mo, A. D. Morris, Filipe A Moura, Jerry L. Nadler, Michael A. Nalls, Uma Nayak, I. Ntalla, Y. Okada, L. Orozco, Sanjay R. Patel, Snehal Patil, P. Pei, Mark A Pereira, A. Peters, F. Pirie, Hannah G. Polikowsky, Bianca C. Porneala, Gauri Prasad, L. Rasmussen-Torvik, Alexander P. Reiner, M. Roden, Rebecca R. Rohde, K. Roll, C. Sabanayagam, Kevin Sandow, Alagu Sankareswaran, Naveed Sattar, S. Schönherr, M. Shahriar, Botong Shen, Jinxiu Shi, Dong Mun Shin, N. Shojima, Jennifer A. Smith, W. So, A. Stančáková, V. Steinthorsdottir, A. Stilp, K. Strauch, K. Taylor, Barbara Thorand, U. Thorsteinsdóttir, B. Tomlinson, Tam C. Tran, F. Tsai, Jaakko Tuomilehto, Teresa Tusié-Luna, M. Udler, A. Valladares-Salgado, Rob M. van Dam, J. V. van Klinken, Rohit Varma, Niels Wacher-Rodarte, Eleanor Wheeler, A. R. Wickremasinghe, Ko Willems van Dijk, D. Witte, C. Yajnik, Kenichi Yamamoto, Kenichi Yamamoto, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, M. Zawistowski, Liang Zhang, Wei Zheng, L. Raffel, M. Igase, Eli Ipp, S. Redline, Yoon Shin Cho, L. Lind, M. Province, M. Fornage, C. Hanis, E. Ingelsson, A. Zonderman, B. Psaty, Ya-Xing Wang, C. Rotimi, Diane M. Becker, Fumihiko Matsuda, Yongmei Liu, M. Yokota, S. Kardia, P. Peyser, J. Pankow, J. Engert, A. Bonnefond, P. Froguel, James G Wilson, W. H. Sheu, Jer-Yuarn Wu, M. Hayes, R. Ma, Tien Y. Wong, D. Mook-Kanamori, T. Tuomi, G. Chandak, F. Collins, D. Bharadwaj, Guillaume Paré, M. Sale, H. Ahsan, A. Motala, X. Shu, K. Park, J. Jukema, Miguel Cruz, Yii-DerIda Chen, S. Rich, R. Mckean-Cowdin, H. Grallert, Ching-Yu Cheng, M. Ghanbari, E. Tai, Jose C Dupuis, Norihiro Kato, M. Laakso, A. Köttgen, Woon-Puay Koh, D. Bowden, Colin N. A. Palmer, J. Kooner, C. Kooperberg, Simin Liu, Kari E. North, D. Saleheen, T. Hansen, O. Pedersen, N. Wareham, Juyoung Lee, Bong-Jo Kim, I. Millwood, R. Walters, K. Stefansson, E. Ahlqvist, M. Goodarzi, K. Mohlke, C. Langenberg, C. Haiman, Ruth J. F. Loos, J. C. Florez, Daniel J. Rader, Marylyn D. Ritchie, Sebastian Zöllner, R. Mägi, N. Marston, C. Ruff, D. V. van Heel, S. Finer, Joshua C. Denny, T. Yamauchi, Takashi Kadowaki, J. C. Chambers, M. Ng, Xueling Sim, J. Below, P. Tsao, Kyong-Mi Chang, M. McCarthy, James B. Meigs, A. Mahajan, Cassandra N. Spracklen, Josep M. Mercader, M. Boehnke, J. Rotter, M. Vujković, B. Voight, A. P. Morris, E. Zeggini   +362 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture

, 2009
Casey S. Greene, Nadia M. Penrod, Scott M. Williams, Jason H. Moore   +3 more
openalex   +2 more sources

The power of genetic diversity in genome-wide association studies of lipids

Nature, 2021
S. Graham, S. Clarke, Kuan-Han H. Wu, S. Kanoni, G. Zajac, S. Ramdas, I. Surakka, I. Ntalla, S. Vedantam, T. Winkler, A. Locke, E. Marouli, M. Y. Hwang, Sohee Han, A. Narita, A. Choudhury, A. Bentley, K. Ekoru, A. Verma, B. Trivedi, H. Martin, K. Hunt, Q. Hui, D. Klarin, Xiang Zhu, G. Thorleifsson, A. Helgadóttir, D. Gudbjartsson, H. Hólm, I. Olafsson, M. Akiyama, S. Sakaue, C. Terao, M. Kanai, Wei Zhou, B. Brumpton, Humaira Rasheed, S. Ruotsalainen, A. Havulinna, Yogasudha Veturi, Q. Feng, E. Rosenthal, T. Lingren, J. Pacheco, S. Pendergrass, J. Haessler, Franco Giulianini, Y. Bradford, Jason E. Miller, A. Campbell, Kuang Lin, I. Millwood, G. Hindy, A. Rasheed, J. Faul, Wei Zhao, D. Weir, Constance Turman, Hongyan Huang, M. Graff, A. Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, S. Gustafsson, X. Yin, J. Luan, Jinghua Zhao, F. Matsuda, Hye-Mi Jang, Kyungheon Yoon, C. Medina-Gomez, A. Pitsillides, J. Hottenga, G. Willemsen, A. Wood, Y. Ji, Zishan Gao, S. Haworth, R. Mitchell, Jin-Fang Chai, M. Aadahl, Jie Yao, A. Manichaikul, H. Warren, J. Ramírez, J. Bork-Jensen, L. Kårhus, A. Goel, M. Sabater-Lleal, R. Noordam, C. Sidore, E. Fiorillo, Aaron F. McDaid, P. Marques-Vidal, M. Wielscher, S. Trompet, N. Sattar, L. Møllehave, B. Thuesen, M. Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, A. Poveda, A. Kurbasic, C. Lamina, L. Forer, M. Scholz, T. Galesloot, J. Bradfield, E. W. Daw, J. Zmuda, J. Mitchell, C. Fuchsberger, Henry Christensen, J. Brody, M. Feitosa, M. Wojczynski, Michael H. Preuss, M. Mangino, P. Christofidou, N. Verweij, J. Benjamins, J. Engmann, R. Kember, R. Slieker, K. S. Lo, Nuno R Zilhao, P. Le, M. Kleber, G. Delgado, Shaofeng Huo, Daisuke D Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, H. Leonard, J. Marten, B. Schmidt, Marina Arendt, L. Smyth, M. Cañadas-Garre, Chaolong Wang, M. Nakatochi, A. Wong, N. Hutri-Kähönen, X. Sim, Rui Xia, A. Huerta-Chagoya, J. Fernández-López, V. Lyssenko, Meraj Ahmed, A. Jackson, M. Irvin, C. Oldmeadow, Han-Na Kim, S. Ryu, P. Timmers, L. Arbeeva, R. Dorajoo, L. Lange, Xiaoran Chai, Gauri Prasad, L. Lorés-Motta, Marc Pauper, J. Long, Xiaohui Li, E. Theusch, F. Takeuchi, Cassandra N. Spracklen, A. Loukola, S. Bollepalli, S. Warner, Y. X. Wang, W. Wei, T. Nutile, D. Ruggiero, Y. Sung, Y. Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, K. Kentistou, Mathias Gorski, M. Brumat, K. Meidtner, L. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, E. Hofer, Maoxuan Lin, C. Xue, Jifeng Zhang, M. P. Concas, S. Vaccargiu, P. J. van der Most, N. Pitkänen, B. Cade, Jiwon Lee, S. W. van der Laan, K. Chitrala, S. Weiss, M. Zimmermann, Jong Young Lee, Hyeok Sun Choi, M. Nethander, S. Freitag-Wolf, L. Southam, N. W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, C. Couture, L. Lyytikäinen, K. Nikus, G. Cuéllar-Partida, H. Vestergaard, Bertha Hildalgo, O. Giannakopoulou, Q. Cai, M. Obura, J. van Setten, Xiaoyin Li, K. Schwander, N. Terzikhan, J. Shin, R. Jackson, A. Reiner, L. Martin, Zhengming Chen, Liming Li, H. Highland, K. Young, T. Kawaguchi, J. Thiery, J. Bis, G. Nadkarni, L. Launer, Huaixing Li, M. Nalls, O. Raitakari, S. Ichihara, S. Wild, C. Nelson, H. Campbell, S. Jäger, T. Nabika, F. Al-Mulla, H. Niinikoski, P. Braund, I. Kolčić, P. Kovacs, Tota Giardoglou, T. Katsuya, K. F. Bhatti, D. D. de Kleijn, G. D. de Borst, E. Kim, H. Adams, M. A. Ikram, Xiaofeng Zhu, F. Asselbergs, A. Kraaijeveld, J. Beulens, X. Shu, L. Rallidis, O. Pedersen, T. Hansen, P. Mitchell, A. Hewitt, M. Kähönen, L. Pérusse, C. Bouchard, A. Tönjes, Y. Chen, C. Pennell, Trevor A. Mori, W. Lieb, A. Franke, C. Ohlsson, D. Mellström, Y. Cho, Hyejin Lee, Jian-Min Yuan, W. Koh, S. Rhee, J. Woo, I. Heid, K. Stark, H. Völzke, G. Homuth, M. Evans, A. Zonderman, O. Polašek, G. Pasterkamp, I. Hoefer, S. Redline, K. Pahkala, A. Oldehinkel, H. Snieder, G. Biino, R. Schmidt, H. Schmidt, Y. E. Chen, S. Bandinelli, G. Dedoussis, T. Thanaraj, S. Kardia, N. Kato, M. Schulze, G. Girotto, B. Jung, C. Böger, Peter K. Joshi, D. Bennett, P. D. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris J. Brown, M. Caulfield, P. Munroe, Xiuqing Guo, M. Ciullo, J. Jonas, N. Samani, J. Kaprio, P. Pajukanta, L. Adair, Sonny A Bechayda, H. J. de Silva, A. R. Wickremasinghe, R. Krauss, Jer-Yuarn Wu, W. Zheng, A. D. den Hollander, D. Bharadwaj, A. Correa, James G. Wilson, L. Lind, C. Heng, A. Nelson, Y. Golightly, James F. Wilson, B. Penninx, Hyung-Lae Kim, J. Attia, R. Scott, D. Rao, D. Arnett, M. Walker, H. Koistinen, G. Chandak, C. Yajnik, J. Mercader, Teresa Tusié-Luna, C. Aguilar-Salinas, Clicerio González Villalpando, L. Orozco, M. Fornage, E. Tai, R. V. van Dam, T. Lehtimäki, N. Chaturvedi, Mitsuhiro Yokota, J. Liu, Dermot F. Reilly, A. McKnight, F. Kee, K. Jöckel, M. McCarthy, C. Palmer, V. Vitart, C. Hayward, E. Simonsick, C. V. van Duijn, F. Lu, J. Qu, H. Hishigaki, Xu Lin, W. März, E. Parra, M. Cruz, V. Gudnason, J. Tardif, G. Lettre, L. T. ’t Hart, P. Elders, S. Damrauer, M. Kumari, M. Kivimaki, P. van der Harst, T. Spector, R. Loos, M. Province, B. Psaty, I. Brandslund, P. Pramstaller, K. Christensen, S. Ripatti, E. Widén, H. Hakonarson, S. Grant, L. Kiemeney, J. de Graaf, M. Loeffler, F. Kronenberg, D. Gu, J. Erdmann, H. Schunkert, P. Franks, A. Linneberg, J. Jukema, A. Khera, M. Männikkö, M. Jarvelin, Z. Kutalik, F. Cucca, D. Mook-Kanamori, K. W. van Dijk, H. Watkins, D. Strachan, N. Grarup, P. Sever, N. Poulter, J. Rotter, T. Dantoft, F. Karpe, M. Neville, N. Timpson, Ching-Yu Cheng, T. Wong, C. Khor, C. Sabanayagam, A. Peters, C. Gieger, A. Hattersley, N. Pedersen, P. Magnusson, D. Boomsma, E. D. de Geus, L. Cupples, J. V. van Meurs, M. Ghanbari, P. Gordon-Larsen, Wei Huang, Y. J. Kim, Y. Tabara, N. Wareham, C. Langenberg, E. Zeggini, J. Kuusisto, M. Laakso, E. Ingelsson, G. Abecasis, J. Chambers, J. Kooner, P. D. de Vries, A. Morrison, K. North, M. Daviglus, P. Kraft, N. Martin, J. Whitfield, S. Abbas, D. Saleheen, R. Walters, M. Holmes, C. Black, Blair H. Smith, A. Justice, A. Baras, J. Buring, P. Ridker, D. Chasman, C. Kooperberg, Wei-Qi Wei, G. Jarvik, B. Namjou, M. Hayes, M. Ritchie, P. Jousilahti, V. Salomaa, K. Hveem, B. Åsvold, M. Kubo, Y. Kamatani, Y. Okada, Y. Murakami, U. Thorsteinsdóttir, K. Stefánsson, Y. Ho, J. Lynch, D. Rader, P. Tsao, Kyong‐Mi Chang, Kelly Cho   +499 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Identifying therapeutic targets for allergic asthma through atopic dermatitis–associated genetic mechanisms

Journal of Allergy and Clinical Immunology: Global
Background: Allergic asthma (AA) is a chronic inflammatory disease with limited effective treatments, often co-occurring with atopic dermatitis (AD). Epidemiologic studies have shown a strong association between AD and AA, but their causal relationship ...
Yuping Pu, MSc, Jundong Liu, PhD, Adam N. Bennett, PhD, Kei Hang Katie Chan, PhD   +3 more
doaj   +1 more source