Results 131 to 140 of about 8,691,632 (395)
Validation in Genetic Association Studies [PDF]
Briefings in Bioinformatics, 2011 Validation of genetic associations is understood to be a cornerstone for the scientific credibility of the results. To approach this topic, the general concept of genetic association studies is introduced briefly, followed by how the term 'validation' is used in the context of genetic association studies.
openaire +3 more sources
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
Association of Lifestyle and Genetic Risk With Incidence of Dementia.
Journal of the American Medical Association (JAMA), 2019 Importance Genetic factors increase risk of dementia, but the extent to which this can be offset by lifestyle factors is unknown. Objective To investigate whether a healthy lifestyle is associated with lower risk of dementia regardless of genetic risk.
Ilianna Lourida +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Nature Genetics, 2018 Neuroticism is an important risk factor for psychiatric traits, including depression1, anxiety2,3, and schizophrenia4–6. At the time of analysis, previous genome-wide association studies7–12 (GWAS) reported 16 genomic loci associated to neuroticism10–12.
M. Nagel +17 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort.
JAMA psychiatry, 2019 Importance The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic, maternal, and environmental effects in ASD across several countries. Objective To estimate
Dan Bai +21 more
semanticscholar +1 more source
Frontiers in ImmunologyBackgroundPrevious studies have reported associations of Crohn’s disease (CD) and ulcerative colitis (UC) with the risks of extraintestinal cancers, but the causality remains unclear.MethodsUsing genetic variations robustly associated with CD and UC ...
Chengdong Yu +8 more
doaj +1 more source
Secondary association between genetically equivalent bivalents [PDF]
, 1964 C. Kempanna, Ralph Riley
openalex +1 more source