Results 131 to 140 of about 8,825,337 (378)
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
Nature Communications, 2019 Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for ...H. Dashti, Samuel E Jones, Andrew R Wood, J. Lane, V. V. van Hees, Heming Wang, Jessica A Rhodes, Yanwei Song, K. Patel, Simon G Anderson, R. Beaumont, D. Bechtold, Jack Bowden, B. Cade, M. Garaulet, S. Kyle, Max A Little, A. Loudon, A. Luik, F. Scheer, K. Spiegelhalder, J. Tyrrell, D. J. Gottlieb, Henning Tiemeier, David W. Ray, Shaun M. Purcell, T. Frayling, S. Redline, D. A. Lawlor, Martin K Rutter, M. Weedon, Richa Saxena +31 moresemanticscholar +1 more sourceMechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer +10 morewiley +1 more sourceAssociation of genetic variants with dyslipidemia
Molecular Medicine Reports, 2015 Although genetic variants, which regulate lipid metabolism, have been extensively investigated in Caucasian populations, the genes, which confer susceptibility to dyslipidemia in Japanese individuals, remain to be elucidated. The aim of the present study was to examine a possible association among hypertriglyceridemia, hypo‑high density lipoprotein ...Kimihiko Kato, Tetsuo Fujimaki, Shintaro Abe, Sachiro Watanabe, Shinya Minatoguchi, Mitsutoshi Oguri, Masazumi Arai, Yoshiji Yamada, Hideki Horibe, Reiko Matsuoka, Toshiyuki Noda, Fumitaka Tokoro +11 moreopenaire +4 more sourcesC9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez +7 morewiley +1 more sourceGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
NatureType 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4.Ken Suzuki, K. Hatzikotoulas, L. Southam, Henry J. Taylor, Xianyong Yin, Kimberly M. Lorenz, Ravi Mandla, A. Huerta-Chagoya, G. Melloni, S. Kanoni, N. W. Rayner, O. Bocher, A. Arruda, K. Sonehara, S. Namba, Simon Lee, Michael H. Preuss, Lauren E Petty, Philip H. Schroeder, Brett R. Vanderwerff, M. Kals, F. Bragg, Kuang Lin, Xiuqing Guo, Weihua Zhang, Jie Yao, Young Jin Kim, M. Graff, F. Takeuchi, J. Nano, A. Lamri, M. Nakatochi, Sanghoon Moon, Robert A. Scott, J. Cook, Jung-Jin Lee, Ian Pan, D. Taliun, E. Parra, Jin-Fang Chai, L. Bielak, Y. Tabara, Y. Hai, G. Thorleifsson, N. Grarup, T. Sofer, M. Wuttke, C. Sarnowski, C. Gieger, Darryl Nousome, S. Trompet, S. Kwak, J. Long, Meng Sun, L. Tong, Wei-Min Chen, Suraj S Nongmaithem, R. Noordam, V. J. Lim, C. H. Tam, Yoonjung Yoonie Joo, Chien-Hsiun Chen, L. Raffield, B. Prins, A. Nicolas, L. Yanek, Guanjie Chen, J. Brody, E. Kabagambe, Ping An, Anny H. Xiang, Hyeok Sun Choi, B. Cade, Jingyi Tan, K. A. Broadaway, A. Williamson, Zoha Kamali, J. Cui, Manonanthini Thangam, Linda S. Adair, A. Adeyemo, C. Aguilar-Salinas, T. Ahluwalia, S. Anand, Alain G. Bertoni, J. Bork-Jensen, Ivan Brandslund, Thomas A. Buchanan, C. Burant, A. Butterworth, M. Canouil, Juliana C N Chan, Li Chang, M. Chee, Ji Chen, Shyh-Huei Chen, Yuan-Tsong Chen, Zhengmin Chen, Lee-Ming Chuang, Mary Cushman, J. Danesh, Swapan K Das, H. D. de Silva, G. Dedoussis, Latchezar Dimitrov, A. Doumatey, S. Du, Qing Duan, K.-U. Eckardt, L. Emery, Daniel S. Evans, Michele K. Evans, K. Fischer, James S Floyd, Ian Ford, Oscar H. Franco, T. Frayling, B. Freedman, P. Genter, H. Gerstein, V. Giedraitis, C. González‐Villalpando, M. González-Villalpando, P. Gordon-Larsen, Myron Gross, Lindsay A Guare, S. Hackinger, L. Hakaste, Sohee Han, Andrew T Hattersley, C. Herder, M. Horikoshi, A. Howard, Willa A. Hsueh, Mengna Huang, Wei Huang, Y. Hung, M. Y. Hwang, C. Hwu, S. Ichihara, M. Ikram, M. Ingelsson, Md. Tariqul Islam, M. Isono, Hye-Mi Jang, F. Jasmine, Guozhi Jiang, J. Jonas, T. Jørgensen, Frederick K. Kamanu, Fouad R. Kandeel, A. Kasturiratne, Tomohiro Katsuya, V. Kaur, T. Kawaguchi, Jacob M. Keaton, Abel N. Kho, C. Khor, M. Kibriya, Duk-Hwan Kim, F. Kronenberg, J. Kuusisto, Kristi Läll, Leslie A. Lange, K. Lee, Myung-Shik Lee, N. Lee, Aaron Leong, Liming Li, Yun Li, Ruifang Li-Gao, Symen Ligthart, Cecilia M. Lindgren, A. Linneberg, Ching-Ti Liu, Jianjun Liu, A. Locke, T. Louie, J. Luan, A. Luk, Xi Luo, Jun Lv, Julie A. Lynch, V. Lyssenko, Shiro Maeda, Vasiliki Mamakou, S. R. Mansuri, Koichi Matsuda, T. Meitinger, Olle Melander, A. Metspalu, Huan Mo, Andrew D. Morris, Filipe A Moura, Jerry L. Nadler, Michael A. Nalls, Uma Nayak, I. Ntalla, Y. Okada, L. Orozco, Sanjay R. Patel, Snehal Patil, P. Pei, Mark A Pereira, A. Peters, F. Pirie, Hannah G. Polikowsky, Bianca C. Porneala, Gauri Prasad, L. Rasmussen-Torvik, Alexander P. Reiner, M. Roden, Rebecca R. Rohde, K. Roll, C. Sabanayagam, Kevin Sandow, Alagu Sankareswaran, Naveed Sattar, S. Schönherr, M. Shahriar, Botong Shen, Jinxiu Shi, Dong Mun Shin, N. Shojima, Jennifer A. Smith, W. So, A. Stančáková, V. Steinthorsdottir, A. Stilp, K. Strauch, K. Taylor, Barbara Thorand, U. Thorsteinsdóttir, B. Tomlinson, Tam C. Tran, F. Tsai, Jaakko Tuomilehto, Teresa Tusié-Luna, M. Udler, A. Valladares-Salgado, Rob M. van Dam, J. V. van Klinken, Rohit Varma, Niels Wacher-Rodarte, Eleanor Wheeler, A. R. Wickremasinghe, Ko Willems van Dijk, Daniel Witte, C. Yajnik, Kenichi Yamamoto, Kenichi Yamamoto, Kyungheon Yoon, Canqing Yu, Jian-Min Yuan, Salim Yusuf, M. Zawistowski, Liang Zhang, Wei Zheng, L. Raffel, M. Igase, Eli Ipp, S. Redline, Yoon Shin Cho, L. Lind, M. Province, M. Fornage, C. Hanis, E. Ingelsson, A. Zonderman, B. Psaty, Ya-Xing Wang, C. Rotimi, Diane Becker, Fumihiko Matsuda, Yongmei Liu, M. Yokota, S. Kardia, P. Peyser, J. Pankow, J. Engert, A. Bonnefond, P. Froguel, James G. Wilson, W. H. Sheu, Jer-Yuarn Wu, M. Hayes, R. Ma, Tien Y. Wong, D. Mook-Kanamori, T. Tuomi, G. Chandak, F. Collins, D. Bharadwaj, Guillaume Paré, M. Sale, H. Ahsan, A. Motala, Xiao-Ou Shu, K. Park, J. Jukema, Miguel Cruz, Yii-DerIda Chen, S. Rich, R. Mckean-Cowdin, H. Grallert, Ching-Yu Cheng, M. Ghanbari, E. Tai, Jose C Dupuis, Norihiro Kato, M. Laakso, A. Köttgen, Woon-Puay Koh, D. Bowden, C. N. Palmer, J. Kooner, C. Kooperberg, Simin Liu, Kari E. North, D. Saleheen, T. Hansen, O. Pedersen, N. Wareham, Juyoung Lee, Bong-Jo Kim, I. Millwood, R. Walters, K. Stefansson, E. Ahlqvist, M. Goodarzi, K. Mohlke, C. Langenberg, C. Haiman, Ruth J. F. Loos, J. C. Florez, Daniel J. Rader, Marylyn D. Ritchie, Sebastian Zöllner, R. Mägi, N. Marston, C. Ruff, D. V. van Heel, S. Finer, Joshua C. Denny, T. Yamauchi, Takashi Kadowaki, J. C. Chambers, M. Ng, Xueling Sim, J. Below, P. Tsao, Kyong-Mi Chang, M. McCarthy, James B. Meigs, A. Mahajan, Cassandra N. Spracklen, Josep M. Mercader, M. Boehnke, J. Rotter, M. Vujković, B. Voight, A. P. Morris, E. Zeggini +362 moresemanticscholar +1 more sourceFTO Polymorphisms are Associated with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Susceptibility in the Older Chinese Han Population
Clinical Interventions in Aging, 2020 Zhan Gu,1,* Yan Bi,2,* Fan Yuan,2,* Ruirui Wang,1 Dong Li,3 Jianying Wang,1 Xiaojuan Hu,1 Guang He,2 Lei Zhang,1 Bao-cheng Liu1 1Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203 ...Gu Z, Bi Y, Yuan F, Wang R, Li D, Wang J, Hu X, He G, Zhang L, Liu B +9 moredoaj Associations between the K232A polymorphism in the diacylglycerol-O-transferase 1 (DGAT1) gene and performance in Irish Holstein-Friesian dairy cattle [PDF]
, 2010 peer-reviewedSelection based on genetic polymorphisms requires accurate quantification of the
effect or association of the polymorphisms with all traits of economic importance.
The objective of this study was to estimate, using progeny performance data Berry, Donagh, Howard, Dawn J., Kearney, J.F., McCabe, Matthew, O'Boyle, Padraig, Waters, Sinead M. +5 morecore
