Results 71 to 80 of about 92,865 (288)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Empirical tools for studying genetic drift in microbial populations [PDF]
, 2022 Deciphering the processes that govern microbial evolution allows us to make predictions of systems ranging from pathogen evolution to climate-driven ecosystem shifts.
Yu, QinQin
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Bottleneck‐associated changes in the genomic landscape of genetic diversity in wild lynx populations
Evolutionary Applications, 2021 Demographic bottlenecks generally reduce genetic diversity through more intense genetic drift, but their net effect may vary along the genome due to the random nature of genetic drift and to local effects of recombination, mutation, and selection.
Maria Lucena‐Perez +5 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Genetic Drift Analysis of Recombination [PDF]
, 2008 : Genetic drift in evolutionary computation, which results from the selection pressure, sampling error and recombination, drives the population to converge to a single individual uniformly, thus causing premature stagnation or losing alternative global ...
Guo Guan-qi, Yu Shou-yi
core
Genie: An interactive real-time simulation for teaching genetic drift [PDF]
, 2018 Neutral evolution is a fundamental concept in evolutionary biology but teaching this and other non-adaptive concepts is specially challenging. Here we present Genie, a browser-based educational tool that facilitates demonstration of concepts such as ...
Ben H. Roos +4 more
core +1 more source
Acta Societatis Botanicorum Poloniae, 2014 The studies included 9 populations of Carex arenaria L. and 7 populations of Carex ligerica Gay, compared with each other on grounds of variability analysis, related to rhizome characters. The sedges reach in the area of Poland their eastern range limits,
Lech Urbaniak
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source