Results 11 to 20 of about 35,558 (147)

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder. No disease‐modifying therapies exist. This review proposes that PD susceptibility begins with epigenetic changes and neuroimmune activity—factors that alter gene expression ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
doaj   +2 more sources

Epigenetic Modulation of IL-7 and IL-10: Toward Personalized Immune Therapies in Viral Epidemics. [PDF]

J Immunol Res
Background Host immune responses, including cytokine production, shape the severity of viral epidemics. Epigenetic mechanisms such as DNA methylation regulate cytokine gene expression and may contribute to immune dysregulation in severe disease. Methods This study analyzed interleukin‐7 (IL‐7), IL‐8, and IL‐10 promoter methylation in 145 COVID‐19 ...
Yulugkural Z, Yildiz M, Topcu E, Elmaslar Mert HT, Temiz A.   +4 more
europepmc   +2 more sources

The Number of Different Binary Functions Generated by NK-Kauffman Networks and the Emergence of Genetic Robustness [PDF]

, 2007
We determine the average number $ \vartheta (N, K) $, of \textit{NK}-Kauffman networks that give rise to the same binary function. We show that, for $ N \gg 1 $, there exists a connectivity critical value $ K_c $ such that $ \vartheta(N,K) \approx e ...
Bechte W., David Romero, de Visser J. A. G. M., Federico Zertuche, Harris B., Kauffman S. A., Kauffman S. A., Kauffman S. A., Kauffman S. A., Lewin B., Romero D., Shymko R. S., Wagner A., Weisbuch G., Winfree A. T.   +14 more
core   +4 more sources

Ageing And Cancer As Diseases Of Epigenesis [PDF]

, 2009
Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core   +2 more sources

Epigenetic regulation in lung cancer

MedComm, Volume 4, Issue 6, December 2023., 2023
Role of epigenetics in lung cancer. Epigenetics is considered the main cause of lung cancer. Epigenetics is categorized into three phenomena: histone modification, DNA methylation, and noncoding RNAs. One of the main approaches to controlling lung cancer is early diagnosis.
Shahin Ramazi, Maedeh Dadzadi, Zahra Sahafnejad, Abdollah Allahverdi   +3 more
wiley   +1 more source

The females' response to male attractiveness: Mate choice, larvae production and differential brain protein expression

Ethology, Volume 129, Issue 10, Page 515-526, October 2023., 2023
Our study in Tenebrio molitor employed behavioral and proteomic analyses to establish a correlation between female mate choice and molecular changes in the female brain. We found that females preferred mating with more attractive males, who in turn had a greater likelihood of successfully mating and producing more larvae with attractive males than with
Miguel Hernández‐Villanueva, Sagrario Cordero‐Molina, Constantino Macías García, Jorge Contreras‐Garduño   +3 more
wiley   +1 more source

The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution [PDF]

, 2018
Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes, the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal' interactions among genes sitting in the different individual ...
Blancke, Stefaan, Braeckman, Johan, De Tiège, Alexis   +2 more
core   +3 more sources

Themes of trust, identity, intimacy, and generativity in important autobiographical memories: Associations with life periods and life satisfaction

Journal of Personality, Volume 91, Issue 5, Page 1110-1122, October 2023., 2023
Abstract Introduction Guided by Erikson's theory of psychosocial development, the present study investigated whether themes of trust, identity, intimacy, and generativity are represented in older adults' most important autobiographical memories. Furthermore, we tested whether these themes are associated with certain life periods and whether having ...
Lisa Nusser, Daniel Zimprich, Tabea Wolf
wiley   +1 more source

Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement

Patterns, 2020
Summary: DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide “snapshot” of >450,000 observations (probe ...
Karen Sugden, Eilis J. Hannon, Louise Arseneault, Daniel W. Belsky, David L. Corcoran, Helen L. Fisher, Renate M. Houts, Radhika Kandaswamy, Terrie E. Moffitt, Richie Poulton, Joseph A. Prinz, Line J.H. Rasmussen, Benjamin S. Williams, Chloe C.Y. Wong, Jonathan Mill, Avshalom Caspi   +15 more
doaj   +1 more source

Relationship between the expression level of microRNA and the features of clinical course of the gallbladder and Оddi's sphincter functional disorders in children

Zaporožskij Medicinskij Žurnal, 2019
The aim of the work is to establish the relationship between the expression levels of microRNA-378f, microRNA-4311, microRNA-4714-3p and anamnestic, clinical and paraclinical parameters of functional disorders of the gallbladder and Oddi's sphincter (FD ...
O. Ye. Abaturov, V. L. Babуch
doaj   +1 more source