Results 21 to 30 of about 32,098 (126)

Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood

Frontiers in Synaptic Neuroscience, 2014
Background: Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals ...
Susan L Andersen, Kai Christian Sonntag
doaj   +1 more source

A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity

Scientific Reports, 2021
Development has intrigued humanity since ancient times. Today, the main paradigm in developmental biology and evolutionary developmental biology (evo-devo) is the genetic program, in which development is explained by the interplay and interaction of ...
Agustín Ostachuk
doaj   +1 more source

Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

Clinical Epigenetics, 2019
Background Ambient air pollution is associated with numerous adverse health outcomes, but the underlying mechanisms are not well understood; epigenetic effects including altered DNA methylation could play a role. To evaluate associations of long-term air
Mi Kyeong Lee, Cheng-Jian Xu, Megan U. Carnes, Cody E. Nichols, James M. Ward, The BIOS consortium, Sung Ok Kwon, Sun-Young Kim, Woo Jin Kim, Stephanie J. London   +9 more
doaj   +1 more source

Factors and mechanisms of productive secondary reservoirs formation in deep-lying oil and gas complexes. Article 1. Tectonophysical mechanisms of Lower Carboniferous quartzite-sandstones decompaction in the central part of the Dniprovsko-Donetska depression at the depths of more than 4.5 km

Мінеральні ресурси України
In the world, the scale of development of secondary reservoirs in decompaction rock bodies in a wide formation range is steadily increasing: from the crystalline basement of different ages of various oil and gas-bearing basins to terrigenous deposits ...
O. Yu. Lukin, I. P. Gafych, Ya. V. Lukin
doaj   +1 more source

A Systematic Review of Adverse Childhood Experiences and Epigenetic Age Acceleration in Later Adult Life Measured With Second and Third‐Generation Epigenetic Clocks

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 4, Page 270-290, June 2026.
ABSTRACT We examined the relationship between adverse childhood experiences (ACEs) and epigenetic age acceleration (EAA) in adulthood as measured by second and third generation epigenetic clocks by performing a systematic review of the literature. The electronic databases MEDLINE and EMBASE were searched on 17 July 2023.
Matthew Green, Laura Horsfall, Azam Saied   +2 more
wiley   +1 more source

Phenotypic Diversity of Marfan Syndrome

JACC: Advances
Marfan syndrome (MFS) is a genetic disorder primarily impacting the cardiovascular system, eyes, and skeletal structure, with its root cause being mutations in the FBN1 gene.
Zixiang Xu, MD, Zhenghong Li, MD, Long Xiang, MD, Tao Chen, MD, Wang Lu, MD, Chang’e Guo, MD, Jinmiao Chen, MD, PhD, Bi’ang Kang, MD, PhD, Zesi Liu, MD, Daokang Xiang, MD, PhD, Liqun Sun, MD, PhD, Kui Hu, MD, PhD   +11 more
doaj   +1 more source

Epigenetics—Innovations and Misconceptions

Natural Sciences, Volume 6, Issue 2, April 2026.
ABSTRACT Epigenetics is a scientific field whose definition has changed over time. Established in the 1940s by C.H. Waddington by synthesis from embryology and genetics, the term “epigenetics” is now mainly used to describe the role of chromatin modifications in the regulation and perpetuation of gene activity states.
Bernhard Horsthemke
wiley   +1 more source

Immune and inflammatory mechanisms in asthma: insights into epigenetic modifications

Frontiers in Immunology
BackgroundAsthma is a chronic respiratory disease influenced by genetic and environmental factors. Emerging evidence highlights epigenetics as a key regulatory mechanism in asthma development.ObjectiveThis research aimed to summarize current evidence on ...
Haixia Fan, Bomeng Zhao, Huiyan Niu, Yan Li, Lu Zhai, Limantian Wang, Shudan Deng, Jie Gao, Xiaoling Gao   +8 more
doaj   +1 more source

Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20–93: The INSPIRE‐T Project

Aging Cell, Volume 24, Issue 10, October 2025.
This study assessed skin biomechanics using the Cutometer in 441 community‐dwelling adults aged 20–93 from the INSPIRE‐T cohort. We demonstrated that skin elasticity and viscoelasticity parameters were associated with the intrinsic capacity (IC) score, a functional marker of healthy aging encompassing cognition, locomotion, psychology, vitality, and ...
Wan‐Hsuan Lu, Sophie Guyonnet, Jérémy Raffin, Sandrine Bessou‐Touya, Katia Ravard Helffer, Pascale Bianchi, Jimmy Le Digabel, Paul Bensadoun, Jean‐Marc Lemaitre, Philipe de Souto Barreto, Bruno Vellas, the IHU HealthAge INSPIRE/Open Science study group, Sophie Guyonnet, Bruno Vellas, Lauréane Brigitte, Agathe Milhet, Elodie Paez, Emeline Muller, Sabine Le Floch, Catherine Takeda, Catherine Faisant, Françoise Lala, Gabor Abellan Van Kan, Zara Steinmeyer, Antoine Piau, Tony Macaron, Davide Angioni, Pierre‐Jean Ousset, Mélanie Comté, Nathalie Daniaud, Fanny Boissou‐Parachaud, Sandrine Andrieu, Christelle Cantet, Yves Rolland, Philipe de Souto Barreto, Fabien Pillard, Bernard Teysseyre, Marie Faruch, Pierre Payoux, Catherine Takeda, Neda Tavassoli, Marie Dorard, Bénédicte Razat, Camille Champigny, Sophie Guyonnet, Cédric Dray, Jean‐Philippe Pradère, Angelo Parini, Yohan Santin, Dominique Langin, Pierre Gourdy, Laurent O. Martinez, Anne Bouloumié, Angelo Parini, Nicolas Fazilleau, Roland Liblau, Jean‐Charles Guéry, Michel Simon, Nicolas Gaudenzio, Luciana Bostan, Hicham El Costa, Nabila Jabrane Ferrat, Philippe Valet, Cedric Dray, Isabelle Ader, Valérie Planat, Louis Casteilla, Pierre Payoux, Patrice Peran, Cyrille Delpierre, Sandrine Andrieu, Claire Rampon, Noelie Davezac, Bruno Guiard, Nathalie Vergnolle, Jean‐Paul Motta, Sara Djebali, Pauline Floch, Céline Deraison, Chrystelle Bonnart, Jean‐Emmanuel Sarry, Nicola Coley, Sophie Guyonnet, Christelle Cantet, Jessica Pontary, Sandrine Andrieu   +85 more
wiley   +1 more source

A Scoping Review of Neighborhood Effects and Health Among Children and Adolescents: Measurement and Design Characteristics

Journal of Community Psychology, Volume 53, Issue 4, May 2025.
ABSTRACT Decades of research have explored how neighborhood conditions relate to child and adolescent health, spawning numerous reviews focused on specific predictors, outcomes, or populations. Less is known about the design and characteristics underpinning this work.
Bria Gresham, Canan Karatekin
wiley   +1 more source