Results 21 to 30 of about 1,980,111 (157)

Relationship between the expression level of microRNA and the features of clinical course of the gallbladder and Оddi's sphincter functional disorders in children

open access: yesZaporožskij Medicinskij Žurnal, 2019
The aim of the work is to establish the relationship between the expression levels of microRNA-378f, microRNA-4311, microRNA-4714-3p and anamnestic, clinical and paraclinical parameters of functional disorders of the gallbladder and Oddi's sphincter (FD ...
O. Ye. Abaturov, V. L. Babуch
doaj   +1 more source

Promoter DNA Methylation Frequency and Clinicopathological Role of miR-129-2 Gene in Patients with Chronic Lymphocytic Leukemia

open access: yesOman Medical Journal, 2020
Objectives: Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of apparently mature B-type lymphocytes in the lymphohematopoietic organs.
Morteza Hashemi   +3 more
doaj   +1 more source

Quercetin as an Emerging Anti-Melanoma Agent: A four-focus area therapeutic development strategy

open access: yesFrontiers in Nutrition, 2016
Replacing current refractory treatments for melanoma with new prevention and therapeutic approaches is crucial in order to successfully treat this aggressive cancer form. Melanoma develops from neural crest cells, which express tyrosinase -- a key enzyme
Zoey Harris   +4 more
doaj   +1 more source

Epigenetic DNA changes and stem cells therapy [PDF]

open access: yesArchive of Oncology, 2013
We are starting to understand the fundamental biological processes which underlie the DNA physical properties. Of particular importance is the field of epigenetics, which literally means 'outside conventional genetics', now used to describe the study ...
Stupar Milanko   +4 more
doaj   +1 more source

Inference of a probabilistic Boolean network from a single observed temporal sequence [PDF]

open access: yes, 2007
The inference of gene regulatory networks is a key issue for genomic signal processing. This paper addresses the inference of probabilistic Boolean networks (PBNs) from observed temporal sequences of network states.
Edward R. Dougherty   +7 more
core   +4 more sources

Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood

open access: yesFrontiers in Synaptic Neuroscience, 2014
Background: Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals ...
Susan L Andersen, Kai Christian Sonntag
doaj   +1 more source

A survey of genetic improvement search spaces [PDF]

open access: yes, 2019
Genetic Improvement (GI) uses automated search to improve existing software. Most GI work has focused on empirical studies that successfully apply GI to improve software's running time, fix bugs, add new features, etc. There has been little research into
Alexander, B   +17 more
core   +1 more source

Epigenesis/Preformation(ism)

open access: yes, 2020
At the end of the nineteenth century, epigenesis and preformationism were presented in An Illustrated Dictionary of Medicine, Biology and allied Sciences as: “epigenesis is in biology, the theory that holds the embryo to be the result of the union of the
Alessandro Ottaviani
core   +1 more source

A network analysis of crab metamorphosis and the hypothesis of development as a process of unfolding of an intensive complexity

open access: yesScientific Reports, 2021
Development has intrigued humanity since ancient times. Today, the main paradigm in developmental biology and evolutionary developmental biology (evo-devo) is the genetic program, in which development is explained by the interplay and interaction of ...
Agustín Ostachuk
doaj   +1 more source

Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults

open access: yesClinical Epigenetics, 2019
Background Ambient air pollution is associated with numerous adverse health outcomes, but the underlying mechanisms are not well understood; epigenetic effects including altered DNA methylation could play a role. To evaluate associations of long-term air
Mi Kyeong Lee   +9 more
doaj   +1 more source

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