Results 11 to 20 of about 35,945 (165)

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder. No disease‐modifying therapies exist. This review proposes that PD susceptibility begins with epigenetic changes and neuroimmune activity—factors that alter gene expression ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
doaj   +2 more sources

Extending Epigenesis: From Phenotypic Plasticity to the Bio-Cultural Feedback [PDF]

Biology and Philosophy, 2017
The paper aims at proposing an extended notion of epigenesis acknowledging an actual causal import to the phenotypic dimension for the evolutionary diversification of life forms.
A Bouaïchi, A Pascual-Leone, A Petronis, A Probst, A Wagner, AD Goldberg, AP Moczek, B Draganski, B Draganski, B Draganski, B Hrvoj-Mihic, C Dupont, CD Allis, CD Schlichting, CH Darwin, CH Darwin, CH Waddington, CH Waddington, CH Waddington, D Amati, D Bickerton, D Stout, D Stout, D Vazquez-Sanroman, DH Ho, DJ Bolger, DJ Cove, E Jablonka, E Jablonka, E Jablonka, E Saló, EE Hecht, EJ Richards, F Calabrese, F Lui, F Lyco, F Vinckier, G Auletta, G Auletta, G Auletta, G Fusco, G Jobard, G Manzi, G Schlosser, G Tononi, GB Müller, GH Tang, GM Edelman, H Gintis, H Ishibashi, H Vries de, I Colagè, I Colagè, I Colagè, I Colagè, I Colagè, ICG Weaver, ICG Weaver, II Schmalhausen, Ivan Colagè, J Caspers, J Masel, J Sapp, J Sapp, J Varrela, J Varrela, J-P Changeux, JD Yeatman, JK Rilling, JM Whitacre, JP Collins, JW Lewis, K Schick, K Woollett, KD Walton, KN Laland, L Caspers, L Cohen, L Daxinger, L Reich, LV Hooper, LV Hooper, M Heiser, M Iacoboni, M Iacoboni, M Kirschner, M Pigliucci, M Ptashne, M Sato, M Somel, M Szwed, M Thiebaut de Schotten, M Vigneau, MH Johnson, MH Johnson, MJ West-Eberhard, ML Anderson, ML Anderson, ML Anderson, ML Anderson, P D’Ambrosio, P Hammerstein, Paolo D’Ambrosio, PF Ferrari, PH Mason, PS Murray, R Amundson, R Gaillard, R Liebers, RA Waterland, RM Burian, RS Corruccini, S Crawford-Young, S Dehaene, S Dehaene, S Dehaene, S Hihara, S Oyama, SE Sultan, SF Gilbert, SF Gilbert, SF Gilbert, SF Gilbert, SJ Gould, SJ Gould, SJ Gould, SK Mazmanian, SM Rogers, T Adell, TJH Morgan, W Arthur, WC Wimsatt, WW Burggren, Z Petanjek, ZM Saygin   +134 more
core   +3 more sources

Epigenetic Modulation of IL-7 and IL-10: Toward Personalized Immune Therapies in Viral Epidemics. [PDF]

J Immunol Res
Background Host immune responses, including cytokine production, shape the severity of viral epidemics. Epigenetic mechanisms such as DNA methylation regulate cytokine gene expression and may contribute to immune dysregulation in severe disease. Methods This study analyzed interleukin‐7 (IL‐7), IL‐8, and IL‐10 promoter methylation in 145 COVID‐19 ...
Yulugkural Z, Yildiz M, Topcu E, Elmaslar Mert HT, Temiz A.   +4 more
europepmc   +2 more sources

Epigenetic regulation in lung cancer

MedComm, Volume 4, Issue 6, December 2023., 2023
Role of epigenetics in lung cancer. Epigenetics is considered the main cause of lung cancer. Epigenetics is categorized into three phenomena: histone modification, DNA methylation, and noncoding RNAs. One of the main approaches to controlling lung cancer is early diagnosis.
Shahin Ramazi, Maedeh Dadzadi, Zahra Sahafnejad, Abdollah Allahverdi   +3 more
wiley   +1 more source

The females' response to male attractiveness: Mate choice, larvae production and differential brain protein expression

Ethology, Volume 129, Issue 10, Page 515-526, October 2023., 2023
Our study in Tenebrio molitor employed behavioral and proteomic analyses to establish a correlation between female mate choice and molecular changes in the female brain. We found that females preferred mating with more attractive males, who in turn had a greater likelihood of successfully mating and producing more larvae with attractive males than with
Miguel Hernández‐Villanueva, Sagrario Cordero‐Molina, Constantino Macías García, Jorge Contreras‐Garduño   +3 more
wiley   +1 more source

Valproic acid and bladder healing: an experimental study in rats

Revista do Colégio Brasileiro de Cirurgiões, 2022
Purpose: to recognize the effects of valproic acid (VPA), an epigenetic drug, on the bladder healing process, in rats. Method: twenty male Wistar rats were divided in two groups: experimental (A), treated with VPA (150mg/Kg/day), and control (B) with ...
MARIA DE LOURDES PESSOLE BIONDO-SIMÕES, MOACIR OLIVEIRA DALL’ANTONIA, MATHEUS PRINCE GOEHR, RACHEL BIONDO-SIMÕES, SÉRGIO OSSAMU IOSHII, ROGÉRIO RIBEIRO ROBES   +5 more
doaj   +2 more sources

Ageing And Cancer As Diseases Of Epigenesis [PDF]

, 2009
Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core   +2 more sources

Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement

Patterns, 2020
Summary: DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide “snapshot” of >450,000 observations (probe ...
Karen Sugden, Eilis J. Hannon, Louise Arseneault, Daniel W. Belsky, David L. Corcoran, Helen L. Fisher, Renate M. Houts, Radhika Kandaswamy, Terrie E. Moffitt, Richie Poulton, Joseph A. Prinz, Line J.H. Rasmussen, Benjamin S. Williams, Chloe C.Y. Wong, Jonathan Mill, Avshalom Caspi   +15 more
doaj   +1 more source

Epigenetics: What it is about? [PDF]

, 2014
Epigenetics has captured the attention of scientists in the past decades, yet its scope has been continuously changing. In this paper, we give an overview on how and why its definition has evolved and suggest several clarification on the concepts used in
Ogryzko, Vasily, Saade, Evelyne
core   +3 more sources

Relationship between the expression level of microRNA and the features of clinical course of the gallbladder and Оddi's sphincter functional disorders in children

Zaporožskij Medicinskij Žurnal, 2019
The aim of the work is to establish the relationship between the expression levels of microRNA-378f, microRNA-4311, microRNA-4714-3p and anamnestic, clinical and paraclinical parameters of functional disorders of the gallbladder and Oddi's sphincter (FD ...
O. Ye. Abaturov, V. L. Babуch
doaj   +1 more source