Results 171 to 180 of about 4,320,960 (307)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Beyond GH stimulation tests: genetic heterogeneity and treatment response in children with diagnosed GH deficiency. [PDF]

J Endocr Soc
Plachy L, Dusatkova P, Kavciak L, Amaratunga SA, Slavenko M, Drabova J, Maratova K, Neuman V, Obermannova B, Kolouskova S, Snajderova M, Sumnik Z, Lebl J, Pruhova S.   +13 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Genetic heterogeneity of residual variance for growth traits in American angus Cattle. [PDF]

J Anim Sci
Amorim ST, Retallick KJ, Garcia A, Ibañez-Escriche N, Morota G.   +4 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Tubular Aggregate Myopathies: Genetic Heterogeneity and Diverse Clinical Features Converging on Calcium Dysregulation. [PDF]

Cells
Serano M, Fiore F, Sorrentino V, Rossi D.   +3 more
europepmc   +1 more source

WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome.

American Journal of Human Genetics, 2018
Janson J. White, J. Mazzeu, Z. Coban-Akdemir, Y. Bayram, Vahid Bahrambeigi, A. Hoischen, B. V. van Bon, A. Gezdirici, E. Gulec, F. Ramond, R. Touraine, J. Thevenon, M. Shinawi, E. Beaver, Jennifer Heeley, J. Hoover-Fong, C. Durmaz, H. Karabulut, Ebru Marzioglu-Ozdemir, A. Çayır, M. Duz, M. Seven, Susan Price, B. M. Ferreira, A. Vianna-Morgante, S. Ellard, A. Parrish, K. Stals, Josue A Flores-Daboub, S. Jhangiani, Richard A. Gibbs, H. Brunner, V. R. Sutton, J. R. Lupski, Claudia M. B. Carvalho   +34 more
semanticscholar   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exploring Genetic Heterogeneity in Type 2 Diabetes Subtypes. [PDF]

Genes (Basel)
Timasheva Y, Kochetova O, Balkhiyarova Z, Avzaletdinova D, Korytina G, Kochetova T, Nouwen A.   +6 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source