Results 181 to 190 of about 945,528 (300)

Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective. [PDF]

Hum Mol Genet
Dack K, Ludwig KU, Stergiakouli E, Sandy J, Aryee S, Davey Smith G, Davies A, Wren Y, Sharp GC, Humphries K, Mangold E, Goudswaard L, Ho K, Dudding T, Lewis SJ.   +14 more
europepmc   +2 more sources

Genetic heterogeneity of hereditary stomatocytosis syndromes showing pseudohyperkalemia [PDF]

, 1999
Ajetunmobi, JF, Carella, M, Delaunay, J, Iolascon, A, Schettini Jr, F, Stewart, GW   +5 more
core  

Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia. [PDF]

Mol Genet Genomic Med
Mohd Dali NS, Aziz NA, Zulkifle MF, Zamri DA, Kamaluddin NR, Yeoh SL, Ho BL, Din ND, Ab Ghani AS, Wan Hassan WAH, Zakaria Z, Esa E, Mat Yusoff Y.   +12 more
europepmc   +1 more source

Genetic heterogeneity [PDF]

, 2019
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition. [PDF]

Front Genet
Onder G, Ozdemir O, Taylan F, Canpolat C, Yalcin K, Erbey F, Sozmen BO, Asarcikli F, Bayhan T, Akcabelen YM, Yarali N, Ozbek NY, Bozkaya IO, Kacar D, Ergun B, Akkus A, Albayrak D, Ince E, Demirsoy U, Ozdemir GN, Dogru O, Aras S, Aydin E, Unal B, Amanvermez U, Dogan OA, Akyoney S, Sayitoglu M, Nordgren A, Bugra Agaoglu N, Ozbek U, Ng OH.   +31 more
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases. [PDF]

Am J Hum Genet
Shaw CA, Williams CJ, Tan T, Illera D, Di N, Shulman JM, Belmont JW.   +6 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer. [PDF]

Cancer Res
Hosseini N, Mannan R, Rebernick RJ, Su F, Wang R, Cao X, Lako A, Mellacheruvu D, Hu J, Alumkal JJ, Reichert ZR, Malik R, Mehra R, Chinnaiyan AM, Cieslik MP.   +14 more
europepmc   +1 more source